Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Priyadarshini Ravichandran"'
Autor:
Shih-Shih Chen, Jacqueline C. Barrientos, Gerardo Ferrer, Morgan King-Richards, Yu-Ju Chen, Priyadarshini Ravichandran, Michael Ibrahim, Yasmine Kieso, Sheila Waters, Jeffery L. Kutok, Marisa Peluso, Sujata Sharma, David T. Weaver, Jonathan A. Pachter, Kanti R. Rai, Nicholas Chiorazzi
Publikováno v:
Clinical Cancer Research. 29:1984-1995
Purpose: Inhibitors of Bruton's tyrosine kinase (BTKi) and PI3K (PI3Ki) have significantly improved therapy of chronic lymphocytic leukemia (CLL). However, the emergence of resistance to BTKi has introduced an unmet therapeutic need. Hence, we sought
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e1d04de0e092c271491cfd78719407a
https://doi.org/10.1158/1078-0432.ccr-22-2386
https://doi.org/10.1158/1078-0432.ccr-22-2386
Autor:
Nicholas Chiorazzi, Kanti R. Rai, Jonathan A. Pachter, David T. Weaver, Sujata Sharma, Marisa Peluso, Jeffery L. Kutok, Sheila Waters, Yasmine Kieso, Michael Ibrahim, Priyadarshini Ravichandran, Yu-Ju Chen, Morgan King-Richards, Gerardo Ferrer, Jacqueline C. Barrientos, Shih-Shih Chen
Effects of inhibition of PI3K isoforms on CLL-cell proliferation, survival, and migration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b915f53399d7fc62583f04718343a06
https://doi.org/10.1158/1078-0432.22820110.v1
https://doi.org/10.1158/1078-0432.22820110.v1
Autor:
Nicholas Chiorazzi, Kanti R. Rai, Jonathan A. Pachter, David T. Weaver, Sujata Sharma, Marisa Peluso, Jeffery L. Kutok, Sheila Waters, Yasmine Kieso, Michael Ibrahim, Priyadarshini Ravichandran, Yu-Ju Chen, Morgan King-Richards, Gerardo Ferrer, Jacqueline C. Barrientos, Shih-Shih Chen
Distinct actions of PI3K-δ and PI3K-γ on mouse cytokines in PDX model of U-CLL and M-CLL patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b26b00c995c8e989d631a712fa85ab
https://doi.org/10.1158/1078-0432.22820098
https://doi.org/10.1158/1078-0432.22820098
Autor:
Nicholas Chiorazzi, Kanti R. Rai, Jonathan A. Pachter, David T. Weaver, Sujata Sharma, Marisa Peluso, Jeffery L. Kutok, Sheila Waters, Yasmine Kieso, Michael Ibrahim, Priyadarshini Ravichandran, Yu-Ju Chen, Morgan King-Richards, Gerardo Ferrer, Jacqueline C. Barrientos, Shih-Shih Chen
Purpose:Inhibitors of Bruton's tyrosine kinase (BTKi) and PI3K (PI3Ki) have significantly improved therapy of chronic lymphocytic leukemia (CLL). However, the emergence of resistance to BTKi has introduced an unmet therapeutic need. Hence, we sought
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3d6e09a3e1db0191cbb96707dd981d
https://doi.org/10.1158/1078-0432.c.6605170
https://doi.org/10.1158/1078-0432.c.6605170
Autor:
Nicholas Chiorazzi, Kanti R. Rai, Jonathan A. Pachter, David T. Weaver, Sujata Sharma, Marisa Peluso, Jeffery L. Kutok, Sheila Waters, Yasmine Kieso, Michael Ibrahim, Priyadarshini Ravichandran, Yu-Ju Chen, Morgan King-Richards, Gerardo Ferrer, Jacqueline C. Barrientos, Shih-Shih Chen
Distinct actions of PI3K-δ and PI3K-γ on numbers of immune cells in CLL.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87dd9ca7a97bfed38be8f5e74a94f745
https://doi.org/10.1158/1078-0432.22652518.v1
https://doi.org/10.1158/1078-0432.22652518.v1
Autor:
Nicholas Chiorazzi, Kanti R. Rai, Jonathan A. Pachter, David T. Weaver, Sujata Sharma, Marisa Peluso, Jeffery L. Kutok, Sheila Waters, Yasmine Kieso, Michael Ibrahim, Priyadarshini Ravichandran, Yu-Ju Chen, Morgan King-Richards, Gerardo Ferrer, Jacqueline C. Barrientos, Shih-Shih Chen
Effects of treatment with duvelisib and ibrutinib on the numbers of T cells in in mice receiving samples from the same patients in Figure 6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f62bd30e4c22c35943a1b68a41f5048
https://doi.org/10.1158/1078-0432.22652509
https://doi.org/10.1158/1078-0432.22652509
Autor:
Nicholas Chiorazzi, Kanti R. Rai, Jonathan A. Pachter, David T. Weaver, Sujata Sharma, Marisa Peluso, Jeffery L. Kutok, Sheila Waters, Yasmine Kieso, Michael Ibrahim, Priyadarshini Ravichandran, Yu-Ju Chen, Morgan King-Richards, Gerardo Ferrer, Jacqueline C. Barrientos, Shih-Shih Chen
IC50 values of PI3K isoform inhibitors used. Duvelisib5, IPI-3063 (PI3K-d inhibitor)5, IPI-549 (PI3K-g inhibitor used in vitro)50, IPI-5243 (PI3K-g inhibitor used in vivo).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ead5388474787e49d884681dd3bc434
https://doi.org/10.1158/1078-0432.22652506
https://doi.org/10.1158/1078-0432.22652506
Autor:
Nicholas Chiorazzi, Kanti R. Rai, Jonathan A. Pachter, David T. Weaver, Sujata Sharma, Marisa Peluso, Jeffery L. Kutok, Sheila Waters, Yasmine Kieso, Michael Ibrahim, Priyadarshini Ravichandran, Yu-Ju Chen, Morgan King-Richards, Gerardo Ferrer, Jacqueline C. Barrientos, Shih-Shih Chen
Distinct actions of PI3K-δ and PI3K-γ on human cytokines in PDX model of U-CLL and M-CLL patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c9f5f39699220b5b922be8cfb2b261
https://doi.org/10.1158/1078-0432.22652515
https://doi.org/10.1158/1078-0432.22652515
Autor:
Shih-Shih Chen, Jacqueline C. Barrientos, Gerardo Ferrer, Priyadarshini Ravichandran, Michael Ibrahim, Yasmine Kieso, Jeffery L. Kutok, Marisa Peluso, Sujata Sharma, David T. Weaver, Jonathan A. Pachter, Kanti R. Rai, Nicholas Chiorazzi
Publikováno v:
Cancer Research. 83:4933-4933
Duvelisib (IPI-145), a first-in-class, oral, dual PI3K-δ,γ inhibitor, has been approved by the FDA for the treatment of patients with chronic lymphocytic leukemia (CLL), small lymphocytic and follicular lymphoma. Duvelisib potently inhibits PI3K-δ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beeeae09c6ee024593abe7f007f8fe86
https://doi.org/10.1158/1538-7445.am2023-4933
https://doi.org/10.1158/1538-7445.am2023-4933
Autor:
Daniel S Ginsburg, Priyadarshini Ravichandran, Azad L Gucwa, Himali Vashishtha, Simon A Davis
Publikováno v:
DNA and Cell Biology. 39:2077-2084
The Tip60 lysine acetyltransferase is a tumor suppressor in most cancers but an oncogene in prostate and gastric cancer. Tip60 is commonly found in the nucleus, where it acetylates proteins involved in transcription, DNA repair, and chromatin; howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e53dc675f201f9ec9abdc7f923ff9fe
https://doi.org/10.1089/dna.2020.5980
https://doi.org/10.1089/dna.2020.5980