Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Priyadarshan K, Damle"'
Autor:
Kranthi Kumar Chougoni, Haemin Park, Priyadarshan K. Damle, Travis Mason, Bo Cheng, Martin M. Dcona, Barbara Szomju, Mikhail G. Dozmorov, Michael O. Idowu, Steven R. Grossman
Publikováno v:
Oncogenesis, Vol 12, Iss 1, Pp 1-8 (2023)
Abstract There is a critical need to identify new therapeutic vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). Transcriptional co-regulators C-terminal binding proteins (CtBP) 1 and 2 are highly overexpressed in human PDAC, and CRISPR-base
Externí odkaz:
https://doaj.org/article/ab4a0b9b5c2c463eaffaa9924dadd679
Autor:
Oluwatoyin E. Akande, Priyadarshan K. Damle, Marius Pop, Nicholas E. Sherman, Barbara B. Szomju, Larisa V. Litovchick, Steven R. Grossman
Publikováno v:
Cell Reports, Vol 26, Iss 12, Pp 3323-3335.e4 (2019)
Summary: The control of p53 protein stability is critical to its tumor suppressor functions. The CREB binding protein (CBP) transcriptional co-activator co-operates with MDM2 to maintain normally low physiological p53 levels in cells via exclusively
Externí odkaz:
https://doaj.org/article/4253af2631464865a6032687bd2ff8cc
Autor:
Steven R. Grossman, Sumitra Deb, Swati Palit Deb, Nitai D. Mukhopadhyay, Priyadarshan K. Damle, Ian M. Love, Rebecca A. Frum
Supplementary figures (1-12) Supplemental Fig. 1. Normalized levels of monoubiquitinated mutant p53 are shown for indicated cell lines analyzed in Fig. 1a. Supplemental Fig. 2. Longer single exposure of p53 blot in Fig. 2a is displayed to demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f01c827b6d04c09c47697d661de1324
https://doi.org/10.1158/1541-7786.22512204.v1
https://doi.org/10.1158/1541-7786.22512204.v1
Autor:
Steven R. Grossman, Sumitra Deb, Swati Palit Deb, Nitai D. Mukhopadhyay, Priyadarshan K. Damle, Ian M. Love, Rebecca A. Frum
Supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01add0cf5d50c08869e88b8ae920de15
https://doi.org/10.1158/1541-7786.22512201.v1
https://doi.org/10.1158/1541-7786.22512201.v1
Autor:
Steven R. Grossman, Sumitra Deb, Swati Palit Deb, Nitai D. Mukhopadhyay, Priyadarshan K. Damle, Ian M. Love, Rebecca A. Frum
Many mutant p53 proteins exhibit an abnormally long half-life and overall increased abundance compared with wild-type p53 in tumors, contributing to mutant p53's gain-of-function oncogenic properties. Here, a novel mechanism is revealed for the maint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::325667192bcbab8aff2317650c7d1a35
https://doi.org/10.1158/1541-7786.c.6540168.v1
https://doi.org/10.1158/1541-7786.c.6540168.v1
Autor:
Kranthi Kumar Chougoni, Haemin Park, Priyadarshan K. Damle, Martin Michael Dcona, Barbara Szomju, Mikhail G. Dozmorov, Michael Idowu, Steven R. Grossman
Publikováno v:
Cancer Research. 82:B073-B073
Pancreatic ductal adenocarcinoma (PDAC) remains among the most lethal of human cancers with a 5-year survival of ~10%, underscoring the need to identify new therapeutic vulnerabilities. Previously, we reported high expression of transcriptional co-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff96cb37eb997218e6438bc4af70e9a2
https://doi.org/10.1158/1538-7445.panca22-b073
https://doi.org/10.1158/1538-7445.panca22-b073
Autor:
Benjamin L. Morris, Dipankar Bandyopadhyay, Zaid Nawaz, Sudha Korwar, Priyadarshan K Damle, Sahib J. Singh, Francisco Zarate-Perez, Carlos Escalante, Michael J Dennis, Xiaoyan Deng, M. Michael Dcona, Keith C Ellis, William E. Royer, Steven R. Grossman
Publikováno v:
Mol Pharmacol
C-terminal binding proteins (CtBP1/2) are oncogenic transcriptional coregulators and dehydrogenases often overexpressed in multiple solid tumors, including breast, colon, and ovarian cancer, and associated with poor survival. CtBPs act by repressing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57ac73f5f618f55277ce3da631760f3
https://doi.org/10.1124/mol.118.114363
https://doi.org/10.1124/mol.118.114363
Autor:
Fang Yuan, Priyadarshan K. Damle, Larisa Litovchick, Steven R. Grossman, Boxiao Ding, Ronny Drapkin
Publikováno v:
Cell Death and Disease, Vol 11, Iss 4, Pp 1-13 (2020)
Cell Death & Disease
Cell Death & Disease
C-terminal binding protein 2 (CtBP2) is elevated in epithelial ovarian cancer, especially in the aggressive and highly lethal subtype, high-grade serous ovarian cancer (HGSOC). However, whether HGSOC tumor progression is dependent on CtBP2 or its par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3a89c768103d0e020a4ddfbe45804e
https://doi.org/10.1038/s41419-020-2455-7
https://doi.org/10.1038/s41419-020-2455-7
Autor:
Michael O. Idowu, Bhaumik B. Patel, Keith C. Ellis, Steven R. Grossman, Barbara Szomju, Priyadarshan K. Damle, Agnes D Cororaton, Ayesha Chawla
Publikováno v:
Oncotarget. 9:32408-32418
C-terminal binding protein 2 (CtBP2) drives intestinal polyposis in the Apcmin mouse model of human Familial Adenomatous Polyposis. As CtBP2 is targetable by an inhibitor of its dehydrogenase domain, understanding CtBP2's role in adenoma formation is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35f8799d40e646843276fb93129a4dac
https://doi.org/10.18632/oncotarget.25784
https://doi.org/10.18632/oncotarget.25784
Autor:
Ayesha T, Chawla, Agnes D, Cororaton, Michael O, Idowu, Priyadarshan K, Damle, Barbara, Szomju, Keith C, Ellis, Bhaumik B, Patel, Steven R, Grossman
Publikováno v:
Oncotarget
C-terminal binding protein 2 (CtBP2) drives intestinal polyposis in the Apc min mouse model of human Familial Adenomatous Polyposis. As CtBP2 is targetable by an inhibitor of its dehydrogenase domain, understanding CtBP2’s role in adenoma formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2870933c5538e21d1ce376b2a6e585b
https://pubmed.ncbi.nlm.nih.gov/30197752
https://pubmed.ncbi.nlm.nih.gov/30197752