Deletion of mdig enhances H3K36me3 and metastatic potential of the triple negative breast cancer cells

Autor: Chitra Thakur, Yiran Qiu, Qian Zhang, Nicholas J. Carruthers, Miaomiao Yu, Zhuoyue Bi, Yao Fu, Priya Wadgaonkar, Bandar Almutairy, Akimasa Seno, Paul M. Stemmer, Fei Chen

Publikováno v: iScience, Vol 25, Iss 10, Pp 105057- (2022)

Summary: In this report, we provide evidence showing diminished expression of the mineral dust-induced gene (mdig), a previously identified oncogenic gene, in human triple negative breast cancer (TNBC). Using a mouse model of orthotopic xenograft of

Externí odkaz: https://doaj.org/article/1c2cbcbf074541f6a44b5dbfde9a3421

Arsenic Activates the ER Stress-Associated Unfolded Protein Response via the Activating Transcription Factor 6 in Human Bronchial Epithelial Cells

Autor: Priya Wadgaonkar, Zhuoyue Bi, Junmei Wan, Yao Fu, Qian Zhang, Bandar Almutairy, Wenxuan Zhang, Yiran Qiu, Chitra Thakur, Maik Hüttemann, Fei Chen

Publikováno v: Biomedicines, Vol 10, Iss 5, p 967 (2022)

Arsenic is a well-known human carcinogen associated with a number of cancers, including lung cancers. We have previously shown that long-term exposure to an environmentally relevant concentration of inorganic arsenic (As3+) leads to the malignant tra

Externí odkaz: https://doaj.org/article/b5b9decba9d84ce8ad1844f3b87495ea

Metabolomic dynamics of the arsenic-transformed bronchial epithelial cells and the derived cancer stem-like cells

Autor: Akimasa Seno, Fei Chen, Yao Fu, Yiran Qiu, Bandar Almutairy, Lingzhi Li, Wenxuan Zhang, Chitra Thakur, Priya Wadgaonkar, Zhuoyue Bi

Publikováno v: International Journal of Biological Sciences

Accumulating evidence indicates a carcinogenic role of environmental arsenic exposure, but mechanisms on how arsenic fosters malignant transformation of the normal cells are not fully established. By applying untargeted global metabolomics approach,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70f40f842ecc89dea022663381bf3dc
http://europepmc.org/articles/PMC8692148

Pathological and Prognostic Indications of the mdig Gene in Human Lung Cancer

Autor: M’Kya Rice, Priya Wadgaonkar, Yuzu Zhao, Bandar Almutairy, Liping Xu, Yongsen Li, Qian Zhang, Chitra Thakur, Hongjuan Cui, Junwei Shi, Yao Fu, Lishen Nie, Zhuoyue Bi, Wenxuan Zhang, Fei Chen, Yiran Qiu

Publikováno v: Cellular Physiology and Biochemistry, Vol 55, Iss S2, Pp 13-28 (2021)
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Background/Aims: The mineral-dust-induced gene mdig is a lung-cancer-associated oncogene. The focus of this study is to evaluate the expression status of mdig in lung cancer and to assess its influence in predicting the patient’s overall survival.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179484f17165b9ee892a6f756e07ee17
https://doi.org/10.33594/000000322

Mdig promotes oncogenic gene expression through antagonizing repressive histone methylation markers

Autor: Yao Fu, Qian Zhang, Benjamin L. Kidder, Fei Chen, Chitra Thakur, Zhipeng Liu, Zhuoyue Bi, Jian Wang, Priya Wadgaonkar, Liping Xu, Wanqing Liu

Publikováno v: Theranostics

The mineral dust-induced gene (mdig) is overexpressed in a number of human cancers, suggesting critical roles of this gene played on the pathogenesis of cancers. Unlike several other JmjC-domain containing proteins that exhibit histone demethylase ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2eea17d7d87e50749c87c4435343d4
https://doi.org/10.7150/thno.36220