Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Priya Tomar"'
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Akademický článek
Inhibiting Pyridoxal Kinase of Entamoeba histolytica Is Lethal for This Pathogen
Autor: Suneeta Devi, Priya Tomar, Khaja Faisal Tarique, Samudrala Gourinath
Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Pyridoxal 5’-phosphate (PLP) functions as a cofactor for hundreds of different enzymes that are crucial to the survival of microorganisms. PLP-dependent enzymes have been extensively characterized and proposed as drug targets in Entamoeba histolyti
Externí odkaz: https://doaj.org/article/3d15ccd97f28442495c5f99eee8f88c4
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N-terminal residues are crucial for quaternary structure and active site conformation for the phosphoserine aminotransferase from enteric human parasite E. histolytica
Autor: Rohit Kumar Singh, Samudrala Gourinath, Priya Tomar, Sudhaker Dharavath, Sudhir Kumar
Publikováno v: International Journal of Biological Macromolecules. 132:1012-1023
Phosphoserine aminotransferase (PSAT) is a pyridoxal-5′phosphate (PLP)-dependent enzyme that catalyzes the second reversible step in the phosphoserine biosynthetic pathway producing serine. The crystal structure of E. histolytica PSAT (EhPSAT) comp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5ba0b141a35e861867d8ec6344f4a6
https://doi.org/10.1016/j.ijbiomac.2019.04.027
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Inhibiting Pyridoxal Kinase of Entamoeba histolytica Is Lethal for This Pathogen
Autor: K.F. Tarique, S. Devi, Samudrala Gourinath, Priya Tomar
Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Pyridoxal 5’-phosphate (PLP) functions as a cofactor for hundreds of different enzymes that are crucial to the survival of microorganisms. PLP-dependent enzymes have been extensively characterized and proposed as drug targets in Entamoeba histolyti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74bb83d2f94284c406c8e0e4e4f5db86
https://doi.org/10.3389/fcimb.2021.660466
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Crystal structure of O-Acetylserine sulfhydralase (OASS) isoform 3 from Entamoeba histolytica: Pharmacophore-based virtual screening and validation of novel inhibitors
Autor: Ramachandran Vijayan, Khushboo Kumari, Priya Tomar, Sudhaker Dharavath, Samudrala Gourinath
Publikováno v: European journal of medicinal chemistry. 192
The l -cysteine is crucial for growth, survival, defense against oxidative stress, and pathogenesis of Entamoeba histolytica. The de novo biosynthesis of l -cysteine in E. histolytica, has a two-step pathway, where O-acetylserine sulfhydrylase (OASS)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb064b1a14e090f6904bc08447d3a4b
https://pubmed.ncbi.nlm.nih.gov/32145643
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6
Structural and thermodynamic characterization of metal binding in Vps29 fromEntamoeba histolytica: implication in retromer function
Autor: Tomoyoshi Nozaki, Sunando Datta, Rupali Yadav, Samudrala Gourinath, Priya Tomar, Natsuki Watanabe, Vijay Kumar Srivastava, Kumiko Nakada-Tsukui, Madhumita Mukherjee
Publikováno v: Molecular Microbiology. 106:562-581
Summary Vps29 is the smallest subunit of retromer complex with metallo-phosphatase fold. Although the role of metal in Vps29 is in quest, its metal binding mutants has been reported to affect the localization of the retromer complex in human cells. I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c95f005a25e284ae1de6428dabd15e8
https://doi.org/10.1111/mmi.13836
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Characterization and functional insights into the Entamoeba histolytica pyridoxal kinase, an enzyme essential for its survival
Autor: Mohammad Farhan Ali, Syed Arif Abdul Rehman, K.F. Tarique, S. Devi, Samudrala Gourinath, Priya Tomar
Publikováno v: Journal of Structural Biology. 212:107645
Pyridoxal 5'-phosphate (PLP) is the active form of vitamin B6 and a cofactor for more than 140 enzymes. This coenzyme plays a pivotal role in catalysis of various enzymatic reactions that are critical for the survival of organisms. Entamoeba histolyt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d467310a1359ca7c452efae3792f38b5
https://doi.org/10.1016/j.jsb.2020.107645
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Structural and functional insights into the stationary-phase survival protein SurE, an important virulence factor ofBrucella abortus
Autor: S. Devi, Samudrala Gourinath, S.A. Abdul Rehman, K.F. Tarique, Priya Tomar
Publikováno v: Acta Crystallographica Section F Structural Biology Communications. 72:386-396
The stationary-phase survival protein SurE fromBrucella abortus(BaSurE) is a metal-dependent phosphatase that is essential for the survival of this bacterium in the stationary phase of its life cycle. Here, BaSurE has been biochemically characterized
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624a116e4ee621f5e40c9871f4d1dc9b
https://doi.org/10.1107/s2053230x16005999
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10
Simultaneous Two-site Blood Culture for Diagnosis of Neonatal Sepsis
Autor: Priya Tomar, Rashee Gupta, Amit Upadhyay, Abhishek Singh, Navratan Kumar Gupta, Amit X. Garg
Publikováno v: Indian pediatrics. 54(3)
To evaluate efficacy of two blood cultures taken simultaneously from two different sites as compared to standard practice of single blood culture in diagnosis of neonatal sepsis. Prospective cohort study. A tertiary-care center at a public hospital.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b241d39f00534b74afd056d78bfe121c
https://pubmed.ncbi.nlm.nih.gov/28984265
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