Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Priya S. Hibshman"'
Autor:
Andrew M. Waters, Tala O. Khatib, Bjoern Papke, Craig M. Goodwin, G. Aaron Hobbs, J. Nathaniel Diehl, Runying Yang, A. Cole Edwards, Katherine H. Walsh, Rita Sulahian, James M. McFarland, Kevin S. Kapner, Thomas S.K. Gilbert, Clint A. Stalnecker, Sehrish Javaid, Anna Barkovskaya, Kajal R. Grover, Priya S. Hibshman, Devon R. Blake, Antje Schaefer, Katherine M. Nowak, Jennifer E. Klomp, Tikvah K. Hayes, Michelle Kassner, Nanyun Tang, Olga Tanaseichuk, Kaisheng Chen, Yingyao Zhou, Manpreet Kalkat, Laura E. Herring, Lee M. Graves, Linda Z. Penn, Hongwei H. Yin, Andrew J. Aguirre, William C. Hahn, Adrienne D. Cox, Channing J. Der
Publikováno v:
Cell Reports, Vol 35, Iss 13, Pp 109291- (2021)
Summary: To identify therapeutic targets for KRAS mutant pancreatic cancer, we conduct a druggable genome small interfering RNA (siRNA) screen and determine that suppression of BCAR1 sensitizes pancreatic cancer cells to ERK inhibition. Integrative a
Externí odkaz:
https://doaj.org/article/24ff658919d8494e80b28117e73c541b
Autor:
Channing J. Der, Antje Schaefer, Christine Sers, Owen J. Sansom, Robert S. Sandler, Alan P. Fields, Adrienne D. Cox, Michael S. Lee, Jen Jen Yeh, Temitope O. Keku, Catriona A. Ford, Andrew D. Campbell, Priya S. Hibshman, Andrew M. Waters, Philipp Jurmeister, Armin Jarosch, David F. Vincent, Karen A. Pickering, Verline Justilien, Dimitri G. Trembath, Gabriela H. Loeza, Joseph A. Galanko, Timothy D. Martin, Melissa Kang, Danielle R. Cook
Supplementary Tables and Methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716f1ec775b2149c51d25ed6b40d85e7
https://doi.org/10.1158/0008-5472.22430088.v1
https://doi.org/10.1158/0008-5472.22430088.v1
Autor:
Channing J. Der, Antje Schaefer, Christine Sers, Owen J. Sansom, Robert S. Sandler, Alan P. Fields, Adrienne D. Cox, Michael S. Lee, Jen Jen Yeh, Temitope O. Keku, Catriona A. Ford, Andrew D. Campbell, Priya S. Hibshman, Andrew M. Waters, Philipp Jurmeister, Armin Jarosch, David F. Vincent, Karen A. Pickering, Verline Justilien, Dimitri G. Trembath, Gabriela H. Loeza, Joseph A. Galanko, Timothy D. Martin, Melissa Kang, Danielle R. Cook
ECT2 is an activator of RHO GTPases that is essential for cytokinesis. In addition, ECT2 was identified as an oncoprotein when expressed ectopically in NIH/3T3 fibroblasts. However, oncogenic activation of ECT2 resulted from N-terminal truncation, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39df620acc21559580a1176438fb783a
https://doi.org/10.1158/0008-5472.c.6513543.v1
https://doi.org/10.1158/0008-5472.c.6513543.v1
Autor:
Channing J. Der, Antje Schaefer, Christine Sers, Owen J. Sansom, Robert S. Sandler, Alan P. Fields, Adrienne D. Cox, Michael S. Lee, Jen Jen Yeh, Temitope O. Keku, Catriona A. Ford, Andrew D. Campbell, Priya S. Hibshman, Andrew M. Waters, Philipp Jurmeister, Armin Jarosch, David F. Vincent, Karen A. Pickering, Verline Justilien, Dimitri G. Trembath, Gabriela H. Loeza, Joseph A. Galanko, Timothy D. Martin, Melissa Kang, Danielle R. Cook
Supplementary Figures S1-S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583ed68e747b4fc91add4c2b36d07c3e
https://doi.org/10.1158/0008-5472.22430085
https://doi.org/10.1158/0008-5472.22430085
Autor:
Jennifer E. Klomp, Jeff A. Klomp, Nathaniel J. Diehl, Cole A. Edwards, Kristina Drizyte-Miller, Priya S. Hibshman, Runying Yang, Alexis J. Morales, Khalilah E. Taylor, Mariaelena Pierobon, Emanuel F. Petricoin, Johnson L. Jared, Emily M. Huntsman, Tomer M. Yaron, Markus Vähä-Koskela, Laura E. Herring, Alex W. Prevatte, Natalie K. Barker, Lee M. Graves, Wennerberg Krister, Lewis C. Cantley, James G. Christensen, Adrienne D. Cox, Channing J. Der, Clint A. Stalnecker
Publikováno v:
Molecular Cancer Research. 21:B034-B034
Direct inhibitors of mutationally activated KRAS are currently under intense preclinical and clinical development, with one KRASG12C mutant-selective inhibitor approved. However, treatment-associated resistance to KRASG12C inhibitors has been reporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97f377f225a46ff56c65429ebd985642
https://doi.org/10.1158/1557-3125.ras23-b034
https://doi.org/10.1158/1557-3125.ras23-b034
Autor:
J Nathaniel, Diehl, Priya S, Hibshman, Irem, Ozkan-Dagliyan, Craig M, Goodwin, Sarah V, Howard, Adrienne D, Cox, Channing J, Der
Publikováno v:
Advances in cancer research. 153
Mutational activation of the KRAS oncogene is found in ~95% of pancreatic ductal adenocarcinoma (PDAC), the major form of pancreatic cancer. With substantial experimental evidence that continued aberrant KRAS function is essential for the maintenance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a855fc36cec614feecbb4ef994e4a35
https://pubmed.ncbi.nlm.nih.gov/35101228
https://pubmed.ncbi.nlm.nih.gov/35101228
Autor:
J. Nathaniel Diehl, Priya S. Hibshman, Irem Ozkan-Dagliyan, Craig M. Goodwin, Sarah V. Howard, Adrienne D. Cox, Channing J. Der
Publikováno v:
Advances in Cancer Research ISBN: 9780128244852
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c83d0b14885bbaa9d598710b3cf1d8e8
https://doi.org/10.1016/bs.acr.2021.07.008
https://doi.org/10.1016/bs.acr.2021.07.008
Autor:
Adrienne D. Cox, Owen J. Sansom, Dimitri G. Trembath, David F. Vincent, Robert S. Sandler, Armin Jarosch, Joseph A. Galanko, Temitope O. Keku, Priya S. Hibshman, Michael S Lee, Melissa Kang, Gabriela H Loeza, Andrew D. Campbell, Philipp Jurmeister, Christine Sers, Timothy D. Martin, Alan P. Fields, Verline Justilien, Jen Jen Yeh, Antje Schaefer, Danielle R. Cook, Catriona A. Ford, Adele Waters, Channing J. Der, Karen Pickering
Publikováno v:
Cancer Res
ECT2 is an activator of RHO GTPases that is essential for cytokinesis. In addition, ECT2 was identified as an oncoprotein when expressed ectopically in NIH/3T3 fibroblasts. However, oncogenic activation of ECT2 resulted from N-terminal truncation, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61605df35641a422079867f9ec5ea2f6
https://europepmc.org/articles/PMC9056178/
https://europepmc.org/articles/PMC9056178/
Autor:
Bjoern Papke, Z. D. Kaiser, Mariaelena Pierobon, Richard G. Hodge, J. N. Diehl, Runying Yang, Thomas S. K. Gilbert, E. Petricoin, Naim U. Rashid, Devon R. Blake, Laura E. Herring, K. R. Snare, Elisa Baldelli, Priya S. Hibshman, Lee M. Graves, Channing J. Der, Jennifer E. Klomp, Adrienne D. Cox
Oncogenic KRAS drives cancer growth by activating diverse signaling networks, not all of which have been fully delineated. We set out to establish a system-wide profile of the KRAS-regulated kinase signaling network (kinome) in KRAS-mutant pancreatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25c42dee576909ed89088756f8fc5656
https://doi.org/10.1101/2021.04.27.441678
https://doi.org/10.1101/2021.04.27.441678
Autor:
Kevin S. Kapner, William C. Hahn, Nanyun Tang, Hongwei H. Yin, Kaisheng Chen, Michelle Kassner, Bjoern Papke, Thomas S. K. Gilbert, A. Cole Edwards, J. Nathaniel Diehl, Sehrish Javaid, Tala O. Khatib, Devon R. Blake, Kajal R. Grover, James M. McFarland, Katherine H. Walsh, Tikvah K. Hayes, Manpreet Kalkat, Katherine M. Nowak, Channing J. Der, G. Aaron Hobbs, Olga Tanaseichuk, Adele Waters, Lee M. Graves, Antje Schaefer, Adrienne D. Cox, Clint A. Stalnecker, Linda Z. Penn, Craig M. Goodwin, Anna Barkovskaya, Andrew J. Aguirre, Priya S. Hibshman, Jennifer E. Klomp, Yingyao Zhou, Laura E. Herring, Rita Sulahian, Runying Yang
Publikováno v:
Cell reports
Cell Reports, Vol 35, Iss 13, Pp 109291-(2021)
Cell Reports, Vol 35, Iss 13, Pp 109291-(2021)
SUMMARY To identify therapeutic targets for KRAS mutant pancreatic cancer, we conduct a druggable genome small interfering RNA (siRNA) screen and determine that suppression of BCAR1 sensitizes pancreatic cancer cells to ERK inhibition. Integrative an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa70e97d6bf8eeb43a46832a616c256d
https://pubmed.ncbi.nlm.nih.gov/34192548
https://pubmed.ncbi.nlm.nih.gov/34192548