Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Priya Kunapuli"'
Autor:
Alan B. Northrup, Yan-Ling Zhang, Zangwei Xu, Michael Weber, Ekaterina V. Bobkova, Priya Kunapuli, Peter Blume-Jensen, Ilona Kariv, Jannik N. Andersen, Joon Jung
Publikováno v:
Journal of Biological Chemistry. 285:18838-18846
The phosphoinositide 3-kinase/AKT signaling pathway plays a key role in cancer cell growth, survival, and angiogenesis. Phosphoinositide-dependent protein kinase-1 (PDK1) acts at a focal point in this pathway immediately downstream of phosphoinositid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8015bd269236cb653d97a02c499579d3
https://doi.org/10.1074/jbc.m109.089946
https://doi.org/10.1074/jbc.m109.089946
Autor:
Sheila McElwee-Whitmer, Eric N. Johnson, Amita Patel, Justin Murray, Chang Bai, Priya Kunapuli
Publikováno v:
Analytical Biochemistry. 385:286-292
The use of ultrahigh throughput screens (uHTS) is a well-accepted mechanism to identify agonists and antagonists of target receptors. We used the Path Hunter [Path Hunter technology is a registered trademark of DiscoveRx Corporation.] technology from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d787a784a0ee2dda61caa9f253c667
https://doi.org/10.1016/j.ab.2008.11.005
https://doi.org/10.1016/j.ab.2008.11.005
Autor:
Adam Gates, Erica Stec, Daniel J. Holder, Yingxue C. Liu, Marc Ferrer, Joseph F. Heyse, Berta Strulovici, Min Xu, Pei Fen Kuan, Xiaohua Douglas Zhang, Priya Kunapuli, Shane D. Marine, Amy S. Espeseth, Xiaohua Shu
Publikováno v:
Nucleic Acids Research
RNA interference (RNAi) is a modality in which small double-stranded RNA molecules (siRNAs) designed to lead to the degradation of specific mRNAs are introduced into cells or organisms. siRNA libraries have been developed in which siRNAs targeting vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9853d0dfc74ccaa4f72c217730ddaf46
https://doi.org/10.1093/nar/gkn435
https://doi.org/10.1093/nar/gkn435
Publikováno v:
ASSAY and Drug Development Technologies. 6:327-337
Members of the superfamily of seven transmembrane receptors, known as G protein-coupled receptors (GPCRs), are important targets for many therapeutic areas in drug discovery. A homogeneous guanosine 5'-O-(3-[(35)S]thio)triphosphate ([(35)S]GTPgammaS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2697b27b209a185a2c655b0dea62ca4
https://doi.org/10.1089/adt.2007.113
https://doi.org/10.1089/adt.2007.113
Integrating Experimental and Analytic Approaches to Improve Data Quality in Genome-wide RNAi Screens
Autor:
Eric M. Stec, Eric N. Johnson, Jayne Chin, Adam Gates, Dan Holder, Lyndon J. Mitnaul, Berta Strulovici, Marc Ferrer, Jenny Tian, Priya Kunapuli, Joseph F. Heyse, Shane Marine, Xiaohua Douglas Zhang, Amy S. Espeseth
Publikováno v:
SLAS Discovery. 13:378-389
RNA interference (RNAi) not only plays an important role in drug discovery but can also be developed directly into drugs. RNAi high-throughput screening (HTS) biotechnology allows us to conduct genome-wide RNAi research. A central challenge in genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ad15756491d54edc34ea617a525899
https://doi.org/10.1177/1087057108317145
https://doi.org/10.1177/1087057108317145
Autor:
Diem N. Nguyen, Samuel L. Graham, Theresa M. Williams, Scott D. Mosser, Ian M. Bell, Bang-Lin Wan, Kimberly Della Penna, Priya Kunapuli, Stefanie A. Kane, Craig A. Stump, Ruth Z. Rutledge, John F. Fay, Ken S. Koblan, Joseph P. Vacca, C. Blair Zartman, Steven N. Gallicchio, Amy G. Quigley, Christopher A. Salvatore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2595-2598
High-throughput screening of the Merck sample collection identified benzodiazepinone tetralin-spirohydantoin 1 as a CGRP receptor antagonist with micromolar activity. Comparing the structure of 1 with those of earlier peptide-based antagonists such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6628f20dd0bcf6f444b0f155b9357fdc
https://doi.org/10.1016/j.bmcl.2006.02.051
https://doi.org/10.1016/j.bmcl.2006.02.051
Autor:
Amy S. Espeseth, Namjin Chung, Priya Kunapuli, Marc Ferrer, Dan Holder, Xiaohua Douglas Zhang, Erica Stec, Adam Gates, Xiting Cindy Yang
Publikováno v:
Pharmacogenomics. 7:299-309
RNA interference (RNAi) high-throughput screening (HTS) experiments carried out using large (>5000 short interfering [si]RNA) libraries generate a huge amount of data. In order to use these data to identify the most effective siRNAs tested, it is cri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea52c861ad15750a49d3a2b143848c7
https://doi.org/10.2217/14622416.7.3.299
https://doi.org/10.2217/14622416.7.3.299
Autor:
Melissa Alberts, Seungtaek Lee, Priya Kunapuli, Anthony Kreamer, Berta Strulovici, Rebecca Mull, Wei Zheng, Jong Ik Hwang, Oleg Kornienko, Melvin I. Simon
Publikováno v:
Analytical Biochemistry. 351:50-61
The recently identified mas-related-gene (MRG) family of receptors, located primarily in sensory neurons of the dorsal root ganglion, has been implicated in the perception of pain. Thus, antagonists of this class of receptors have been postulated to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c224a0ef5fcbcee68d79ecdad191ea
https://doi.org/10.1016/j.ab.2006.01.014
https://doi.org/10.1016/j.ab.2006.01.014
Autor:
Zhong Zhong, Michael Platchek, Berta Strulovici, Rebecca Mull, Michael Weber, Mei Cong, Kelli Solly, Priya Kunapuli, Wei Zheng
Publikováno v:
ASSAY and Drug Development Technologies. 3:17-26
Cell-based functional assays are becoming popular in many HTS laboratories because of recent advances in detection and automation technologies. However, the supply of large amounts of live cells with consistent cellular response for day-to-day screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ecfd4c004fa2ea7f20ff374c799f985
https://doi.org/10.1089/adt.2005.3.17
https://doi.org/10.1089/adt.2005.3.17
Publikováno v:
ASSAY and Drug Development Technologies. 2:39-49
Guanosine triphosphate binding protein (G protein)-coupled receptors (GPCRs) are a large class of pharmaceutical drug targets. With the increasing popularity of functional assays for high throughput screening, there arises an increasing need for robu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38b2a98295c235afeef3f07f38b4968
https://doi.org/10.1089/154065804322966306
https://doi.org/10.1089/154065804322966306