Synovial Fluid in Knee Osteoarthritis Extends Proinflammatory Niche for Macrophage Polarization

Autor: Priya Kulkarni, Vanshika Srivastava, Kaspar Tootsi, Ali Electricwala, Avinash Kharat, Ramesh Bhonde, Sulev Koks, Aare Martson, Abhay Harsulkar

Publikováno v: Cells, Vol 11, Iss 24, p 4115 (2022)

Macrophage polarization is a steering factor of osteoarthritis (OA) progression. Synovial fluid (SF) obtained from OA patients with different Kellgren–Lawrence grades (KL grades) holds several proinflammatory factors and was hypothesized to induce

Externí odkaz: https://doaj.org/article/283311edae9b4f85b590b92ea85a8ab6

Nutritional Status of Adolescent Girls in Corporation Schools in India: Still the Goal is Far Ahead

Autor: Priya Kulkarni, Archana Jadhav, JS Bhawalkar

Publikováno v: Journal of Pharmaceutical Research International. :42-49

Adolescence is a vulnerable period for the incidence of malnutrition, as rapid growth takes place in this phase of life. Malnutrition, especially among adolescent girls, adversely affects future generations and indirectly impedes national productivit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86bc3958458b8c1aa0c2b95ce871ce61
https://doi.org/10.9734/jpri/2021/v33i46a32839

Pharmacokinetics of the Monoclonal Antibody MHAA4549A Administered in Combination With Oseltamivir in Patients Hospitalized With Severe Influenza A Infection

Autor: Jacqueline McBride, Melicent C. Peck, Priscilla Horn, Priya Kulkarni, Jeremy J. Lim, Jorge A. Tavel, Gaohong She, Rong Deng, Aide Castro, Elizabeth M. Newton, William D. Hanley, Mauricio Maia

Publikováno v: Journal of Clinical Pharmacology

MHAA4549A is a human anti‐influenza A monoclonal antibody developed to treat influenza A. We report MHAA4549A serum, nasopharyngeal, and tracheal aspirate pharmacokinetics from a phase 2b study in hospitalized patients with severe influenza A. Pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162e5620d2382dd138b80b5267261979
https://doi.org/10.1002/jcph.1652

Mast Cells Differentiated in Synovial Fluid and Resident in Osteophytes Exalt the Inflammatory Pathology of Osteoarthritis

Autor: Priya Kulkarni, Abhay Harsulkar, Anne-Grete Märtson, Siim Suutre, Aare Märtson, Sulev Koks

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 541
International Journal of Molecular Sciences, Vol 23, Iss 541, p 541 (2022)

Introduction: Osteophytes are a prominent feature of osteoarthritis (OA) joints and one of the clinical hallmarks of the disease progression. Research on osteophytes is fragmentary and modes of its contribution to OA pathology are obscure. Aim: To el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da760db375ad7897b6eab477734509d4
https://pubmed.ncbi.nlm.nih.gov/35008966

Synovium-Synovial Fluid Axis in Osteoarthritis Pathology: A Key Regulator of the Cartilage Degradation Process

Autor: Sulev Kõks, Aare Märtson, Suresh Jagtap, Dhanashri R Ingale, Alpana Moghe, Ali Electricwala, Sara Kamyab, Abhay Harsulkar, Priya Kulkarni

Publikováno v: Genes
Volume 12
Issue 7
Genes, Vol 12, Iss 989, p 989 (2021)

Failure of conventional anti-inflammatory therapies in osteoarthritis (OA) underlines the insufficient knowledge about inflammatory mechanisms, patterns and their relationship with cartilage degradation. Considering non-linear nature of cartilage los

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1c498713675d364ed6e88cb4c2630c