Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Pritisha ROZARIO"'
Autor:
Dylan Hong Zheng Koh, Tomoki Naito, Minyoung Na, Yee Jie Yeap, Pritisha Rozario, Franklin L. Zhong, Kah-Leong Lim, Yasunori Saheki
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Cholesterol is important for membrane integrity and cell signaling, and dysregulation of the distribution of cellular cholesterol is associated with numerous diseases, including neurodegenerative disorders. While regulated transport of a spe
Externí odkaz:
https://doaj.org/article/91c41d6838114740a6485960bdefe6bb
Autor:
Aaron T. Irving, Qian Zhang, Pui-San Kong, Katarina Luko, Pritisha Rozario, Ming Wen, Feng Zhu, Peng Zhou, Justin H.J. Ng, Radoslaw M. Sobota, Lin-Fa Wang
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108345- (2020)
Summary: Bat cells and tissue have elevated basal expression levels of antiviral genes commonly associated with interferon alpha (IFNα) signaling. Here, we show Interferon Regulatory Factor 1 (IRF1), 3, and 7 levels are elevated in most bat tissues
Externí odkaz:
https://doaj.org/article/1a481bd494ec45cba71a7d42d304574a
Autor:
Kim S. ROBINSON, Gee Ann TOH, Muhammad Jasrie FIRDAUS, Khek Chian THAM, Pritisha ROZARIO, Chrissie LIM, Ying Xiu TOH, Zhi Heng LAU, Sophie Charlotte BINDER, Jacob MAYER, Carine BONNARD, Florian I. SCHMIDT, John E. A. COMMON, Franklin L. ZHONG
NLRP1 is an innate immune sensor protein that activates inflammasome-driven pyroptotic cell death. Recent work demonstrates that human NLRP1 has evolved to sense viral infections. Whether and how human NLRP1 responds to other infectious agents is unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad76428c5948ff4f0a10289c3b7465b3
https://doi.org/10.1101/2023.01.16.524188
https://doi.org/10.1101/2023.01.16.524188
Autor:
Kim S. Robinson, Gee Ann Toh, Pritisha Rozario, Rae Chua, Stefan Bauernfried, Zijin Sun, Muhammad Jasrie Firdaus, Shima Bayat, Rhea Nadkarni, Zhi Sheng Poh, Khek Chian Tham, Cassandra R. Harapas, Chrissie K. Lim, Werncui Chu, Celest W. S. Tay, Kiat Yi Tan, Tianyun Zhao, Carine Bonnard, Radoslaw Sobota, John E. Connolly, John Common, Seth L. Masters, Kaiwen W. Chen, Lena Ho, Bin Wu, Veit Hornung, Franklin L. Zhong
Publikováno v:
Science
Human NLRP1 (NACHT, LRR, and PYD domain-containing protein 1) is an innate immune sensor predominantly expressed in the skin and airway epithelium. Here, we report that human NLRP1 senses the ultraviolet B (UVB)- and toxin-induced ribotoxic stress re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd55eb9fb17b0a64b9dd5b750c23776
https://pubmed.ncbi.nlm.nih.gov/35857590
https://pubmed.ncbi.nlm.nih.gov/35857590
Autor:
Matae Ahn, Vivian Chih-Wei Chen, Pritisha Rozario, Wei Lun Ng, Pui San Kong, Wan Rong Sia, Adrian Eng Zheng Kang, Qi Su, Lan Huong Nguyen, Feng Zhu, Wharton O.Y. Chan, Chee Wah Tan, Wan Shoo Cheong, Ying Ying Hey, Randy Foo, Fusheng Guo, Yan Ting Lim, Xin Li, Wan Ni Chia, Radoslaw M. Sobota, Nai Yang Fu, Aaron T. Irving, Lin-Fa Wang
Publikováno v:
Cell. 186:2144-2159.e22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3d1e08d32e4b5aded78a42384db094e
https://doi.org/10.1016/j.cell.2023.03.036
https://doi.org/10.1016/j.cell.2023.03.036
Autor:
Kim S. Robinson, Gee Ann Toh, Pritisha Rozario, Shima Bayat, Zijin Sun, Stefan Bauernfried, Rhea Nadkarni, Cassandra R. Harapas, Chrissie K. Lim, Werncui Chu, Kiat Yi Tan, Carine Bonnard, Radoslaw Sobota, John E. Connolly, Seth L. Masters, Kaiwen W. Chen, Lena Ho, Veit Hornung, Franklin L. Zhong
Human NLRP1 is a multifunctional inflammasome sensor predominantly expressed in skin and airway epithelium; however its function in skin-specific immunity and its mechanisms of activation are not fully understood. Here we report that human NLRP1 is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::528d68a0f807bf495e55628698a44052
https://doi.org/10.1101/2022.01.24.477516
https://doi.org/10.1101/2022.01.24.477516
Autor:
Katarina Luko, Pritisha Rozario, Lin-Fa Wang, H. Benjamin Larman, Benjamin Py H. Lee, Stephen J. Elledge, Ian H. Mendenhall, Shailendra Mani, Jeffrey J. Gorman, Marcus L. Hastie, Pui San Kong, Aaron T. Irving, Gavin J. D. Smith, Wan Ni Chia
Publikováno v:
Cellular and Molecular Life Sciences. 77:1607-1622
Natural reservoir hosts can sustain infection of pathogens without succumbing to overt disease. Multiple bat species host a plethora of viruses, pathogenic to other mammals, without clinical symptoms. Here, we detail infection of bat primary cells, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d405a572d5b9dd8a59ef361d76b81d
https://doi.org/10.1007/s00018-019-03242-x
https://doi.org/10.1007/s00018-019-03242-x
Autor:
Peng Zhou, Katarina Luko, Aaron T. Irving, Radoslaw M. Sobota, Lin-Fa Wang, Justin H. J. Ng, Pritisha Rozario, Qian Zhang, Feng Zhu, Ming Wen, Pui San Kong
Publikováno v:
Cell Reports
Cell Reports, Vol 33, Iss 5, Pp 108345-(2020)
Cell Reports, Vol 33, Iss 5, Pp 108345-(2020)
Bat cells and tissue have elevated basal expression levels of antiviral genes commonly associated with interferon alpha (IFNα) signaling. Here, we show Interferon Regulatory Factor 1 (IRF1), 3, and 7 levels are elevated in most bat tissues and that,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ce5c5b0d1b692440456a24b946f32c
https://doi.org/10.1016/j.celrep.2020.108345
https://doi.org/10.1016/j.celrep.2020.108345