Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Prithiba Mitra"'
Autor:
Ralph Krafczyk, Jakub Macošek, Pravin Kumar Ankush Jagtap, Daniel Gast, Swetlana Wunder, Prithiba Mitra, Amit Kumar Jha, Jürgen Rohr, Anja Hoffmann-Röder, Kirsten Jung, Janosch Hennig, Jürgen Lassak
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT Glycosylation is a universal strategy to posttranslationally modify proteins. The recently discovered arginine rhamnosylation activates the polyproline-specific bacterial translation elongation factor EF-P. EF-P is rhamnosylated on arginine
Externí odkaz:
https://doaj.org/article/e5dfd8c25c524c26a390fbfaa6131228
Autor:
Prithiba Mitra, Barnali Das
The conventional sequence comparison-based evolutionary studies ignore other evolutionary constraints like interaction among proteins, functions of proteins and genes etc. A lot of speculations exist in literature regarding the presence of species di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f8763c19c81c82c4956cc66f0a56aa6
https://doi.org/10.1101/2021.06.03.446976
https://doi.org/10.1101/2021.06.03.446976
Autor:
Shaimaa M. Salem, Amit Kumar Jha, Joseph M. Eckenrode, Jürgen Rohr, Abhisek Mandal, Prithiba Mitra, Markos Leggas
Publikováno v:
Journal of Medicinal Chemistry. 61:8001-8016
Mithramycin A (1) was identified as the top potential inhibitor of the aberrant ETS transcription factor EWS-FLI1, which causes Ewing sarcoma. Unfortunately, 1 has a narrow therapeutic window, compelling us to seek less toxic and more selective analo
Autor:
Chirlei Glienke, Daiani Cristina Savi, Jürgen Rohr, Khaled A. Shaaban, Amit Kumar Jha, Prithiba Mitra, Jon S. Thorson, Aliandra G. de Medeiros
Publikováno v:
Folia Microbiologica. 63:499-505
Antibiotic-resistant bacteria have been observed with increasing frequency over the past decades, driving the search for new drugs and stimulating the interest in natural products sources. Endophytic fungi from medicinal plants represent a great sour
Autor:
Prithiba Mitra, Xia Yu, Frank Herkules, Oleg V. Tsodikov, Ryan Wheeler, Caixia Hou, Jhong Min Chen, Dmitri N. Ivanov, Jürgen Rohr
Publikováno v:
Angew Chem Int Ed Engl
MtmOIV and MtmW catalyze the final two reactions in the mithramycin (MTM) biosynthetic pathway, the Baeyer-Villiger opening of the fourth ring of premithramycin B (PMB), creating the C3 pentyl side chain, strictly followed by reduction of the distal
Publikováno v:
Biomedical Chromatography. 33
Mithramycin (MTM) has potent anticancer activity, but severe toxicities restrict its clinical use. Semi-synthetic approaches have yielded novel MTM analogs with potentially lower toxicity and similar efficacy. In an effort to transition these analogs
Autor:
Jon S. Thorson, Markos Leggas, Reiya Hayden, Abhisek Mandal, Jürgen Rohr, Prithiba Mitra, Caixia Hou, Oleg V. Tsodikov
Publikováno v:
The FASEB Journal. 33
Autor:
Khaled A. Shaaban, Jürgen Rohr, Larissa V. Ponomareva, Chirlei Glienke, Prithiba Mitra, Daiani Cristina Savi, Jon S. Thorson
Publikováno v:
J Antibiot (Tokyo)
The isolation and structure elucidation of one new fungal metabolite, phenguignardic acid butyl ester (1a), and four previously reported metabolites (1b, 2a, 3-4) from the citrus phytopathogen Phyllosticta citricarpa LGMF06 are described. The new dio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011a863232c83c7dabce19a7a2442767
https://europepmc.org/articles/PMC6557267/
https://europepmc.org/articles/PMC6557267/
Autor:
Zhonghua Wang, Oleg V. Tsodikov, Dmitri N. Ivanov, Kristin E. Cano, Caixia Hou, Stevi Weidenbach, Prithiba Mitra, Jürgen Rohr
Publikováno v:
Nucleic Acids Research
Transcription factors have been considered undruggable, but this paradigm has been recently challenged. DNA binding natural product mithramycin (MTM) is a potent antagonist of oncogenic transcription factor EWS-FLI1. Structural details of MTM recogni
Autor:
Prithiba Mitra, Joseph M. Eckenrode, Reiya Hayden, Jon S. Thorson, Markos Leggas, Jürgen Rohr
Publikováno v:
The FASEB Journal. 32