Biodegradable scaffolds promote tissue remodeling and functional improvement in non-human primates with acute spinal cord injury.

Autor: Slotkin JR; Department of Neurosurgery, Geisinger Clinic, Danville, PA, USA., Pritchard CD; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Luque B; InVivo Therapeutics Corporation, Cambridge, MA, USA., Ye J; InVivo Therapeutics Corporation, Cambridge, MA, USA., Layer RT; InVivo Therapeutics Corporation, Cambridge, MA, USA. Electronic address: rlayer@invivotherapeutics.com., Lawrence MS; RxGen, Hamden, CT, USA., O'Shea TM; Harvard-Massachusetts Institute of Technology, Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Roy RR; Brain Research Institute, University of California, Los Angeles, CA, USA; Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA., Zhong H; Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA., Vollenweider I; Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland., Edgerton VR; Brain Research Institute, University of California, Los Angeles, CA, USA; Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA; Departments of Neurobiology and Neurology, University of California, Los Angeles, CA, USA., Courtine G; Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland., Woodard EJ; Department of Neurosurgery, New England Baptist Hospital, Boston, MA, USA., Langer R; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA; Harvard-Massachusetts Institute of Technology, Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

Publikováno v: Biomaterials [Biomaterials] 2017 Apr; Vol. 123, pp. 63-76. Date of Electronic Publication: 2017 Jan 25.

Painting blood vessels and atherosclerotic plaques with an adhesive drug depot.

Autor: Kastrup CJ; Department of Chemical Engineering and Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Nahrendorf M, Figueiredo JL, Lee H, Kambhampati Thiruvengadam S, Lee T, Cho SW, Gorbatov R, Iwamoto Y, Dang TT, Dutta P, Yeon JH, Cheng H, Pritchard CD, Vegas AJ, Siegel CD, MacDougall S, Okonkwo M, Thai A, Stone JR, Coury AJ, Weissleder R, Langer R, Anderson DG

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2012 Dec 26; Vol. 109 (52), pp. 21444-9. Date of Electronic Publication: 2012 Dec 11.

An injectable thiol-acrylate poly(ethylene glycol) hydrogel for sustained release of methylprednisolone sodium succinate.

Autor: Pritchard CD; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. cpritcha@mit.edu, O'Shea TM, Siegwart DJ, Calo E, Anderson DG, Reynolds FM, Thomas JA, Slotkin JR, Woodard EJ, Langer R

Publikováno v: Biomaterials [Biomaterials] 2011 Jan; Vol. 32 (2), pp. 587-97. Date of Electronic Publication: 2010 Sep 28.

Establishing a model spinal cord injury in the African green monkey for the preclinical evaluation of biodegradable polymer scaffolds seeded with human neural stem cells.

Autor: Pritchard CD; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. cpritcha@mit.edu, Slotkin JR, Yu D, Dai H, Lawrence MS, Bronson RT, Reynolds FM, Teng YD, Woodard EJ, Langer RS

Publikováno v: Journal of neuroscience methods [J Neurosci Methods] 2010 May 15; Vol. 188 (2), pp. 258-69. Date of Electronic Publication: 2010 Feb 26.

Blockade of peroxynitrite-induced neural stem cell death in the acutely injured spinal cord by drug-releasing polymer.

Autor: Yu D; Department of Neurosurgery, Harvard Medical School, The Brigham and Women's Hospital and Children's Hospital Boston, Boston, MA 02115, USA., Neeley WL, Pritchard CD, Slotkin JR, Woodard EJ, Langer R, Teng YD

Publikováno v: Stem cells (Dayton, Ohio) [Stem Cells] 2009 May; Vol. 27 (5), pp. 1212-22.