Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Priscilla L. White"'
Autor:
Michael Foley, Andre Lescarbeau, Martin R. Tremblay, Lombardy Richard John, Grogan Michael John, Andrew B. Hague, Kristopher M. Depew, Jimin Xiong, Joseph Helble, Priscilla L. White, Julian Adams, Brian C. Austad, Caroline D. Lory, Somarajan J. Nair, Stéphane Peluso, Lin-Chen Yu, Alfredo C. Castro, André B. Charette, Benjamin S. Lane, Jeanne Shaffer, Louis Grenier, James R. Porter, Matthew Campbell, Koney Nii O, Mark L. Behnke
Publikováno v:
Organic Process Research & Development. 20:786-798
The formation of the d-homocyclopamine ring system in IPI-926 is the key step in its semisynthesis and proceeds via a chemoselective cyclopropanation followed by a stereoselective acid-catalyzed carbocation rearrangement. In order to perform large-sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a9debb0b604cbda59d104def86c7642
https://doi.org/10.1021/acs.oprd.6b00048
https://doi.org/10.1021/acs.oprd.6b00048
Autor:
Martin Trudeau, Louis Grenier, Kristopher M. Depew, Daniel G. Genov, Alexandre Côté, Brian C. Austad, Lin-Chen Yu, Andre Lescarbeau, Theodore A. Martinot, Priscilla L. White, Joseph Helble, Somarajan J. Nair
Publikováno v:
Organic Process Research & Development. 19:1693-1702
A design of experiments (DoE) approach was taken to optimize purity and reaction yield of the final debenzylation and hydrochloride salt formation of IPI-926. The study involved a careful dissection of the different process steps to enable an indepen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::303b6bb1bcb0f53d2408fcb4957573f0
https://doi.org/10.1021/acs.oprd.5b00214
https://doi.org/10.1021/acs.oprd.5b00214