Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Priscilla Krai"'
Autor:
Joshua H. Butler, Heather J. Painter, Emily K. Bremers, Priscilla Krai, Manuel Llinás, Maria B. Cassera
Publikováno v:
Molecules, Vol 28, Iss 6, p 2600 (2023)
Cripowellins from Crinum erubescens are known pesticidal and have potent antiplasmodial activity. To gain mechanistic insights to this class of natural products, studies to determine the timing of action of cripowellins within the asexual intraerythr
Externí odkaz:
https://doaj.org/article/6cf11419fab045429664fe7e78ccc009
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89771 (2014)
During the asexual intraerythrocytic stage, the malaria parasite Plasmodium falciparum must traffic newly-synthesized proteins to a broad array of destinations within and beyond the parasite's plasma membrane. In this study, we have localized two wel
Externí odkaz:
https://doaj.org/article/48a3139a75f649c0b6f4a37694bf70cc
Autor:
Joshua H. Butler, Heather J. Painter, Emily K. Bremers, Priscilla Krai, Manuel Llinás, Maria B. Cassera
Publikováno v:
Molecules; Volume 28; Issue 6; Pages: 2600
Cripowellins from Crinum erubescens are known pesticidal and have potent antiplasmodial activity. To gain mechanistic insights to this class of natural products, studies to determine the timing of action of cripowellins within the asexual intraerythr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11435dd6e7b43d8df54387bab52046e
https://doi.org/10.3390/molecules28062600
https://doi.org/10.3390/molecules28062600
Autor:
Priscilla Krai, Seema Dalal, David G. I. Kingston, Maria B. Cassera, Michael Goetz, Qingxi Su, Christopher C. Presley
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:5418-5422
Antimalarial bioassay-guided fractionation of the swamp lily Crinum erubescens led to the isolation of four compounds with potent antiplasmodial activity. Compounds 1 and 2 were determined from their spectroscopic data to be the known pesticidal comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0374de72339b41d0d93a2f8eb24922db
https://doi.org/10.1016/j.bmc.2016.08.058
https://doi.org/10.1016/j.bmc.2016.08.058
Publikováno v:
Planta Medica. 81:1128-1132
Bioassay-guided fractionation of an EtOH extract of the roots of the plant Apoplanesia paniculata (Fabaceae) led to the isolation of the three known compounds amorphaquinone ( 1 ), pendulone ( 2 ), and melilotocarpan C ( 3 ), and the two new pterocar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc55f5a4e86ab75cd629f4503fd4df86
https://doi.org/10.1055/s-0035-1546036
https://doi.org/10.1055/s-0035-1546036
Autor:
Emilio F. Merino, Carla Slebodnick, Priscilla Krai, Zhong-Ke Yao, Morgan Simpson, Paul R. Carlier, Maria B. Cassera
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1515-1519
Compounds that target isoprenoid biosynthesis in Plasmodium falciparum could be a welcome addition to malaria chemotherapy, since the methylerythritol phosphate (MEP) pathway used by the parasite is not present in humans. We previously reported that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d8d84b7fb4dcfcd698146b25938ad7
https://doi.org/10.1016/j.bmcl.2015.02.020
https://doi.org/10.1016/j.bmcl.2015.02.020
Autor:
Jessica D. Wiley, L. Harinantenaina Rakotondraibe, David G. I. Kingston, Vincent E. Rasamison, Olson Monica Britt, Paul R. Graupner, Peggy J. Brodie, Quanbo Xiong, Priscilla Krai, Etienne Rakotobe, Donald R. Hahn, Fidy Ratovoson, Serge Fotso, Maria B. Cassera, Martin W. Callmander
Publikováno v:
Journal of Natural Products. 78:431-440
Ten new neolignans including the 6′-oxo-8.1′-lignans cymosalignans A (1a), B (2), and C (3), an 8.O.6′-neolignan (4a), ococymosin (5a), didymochlaenone C (6a), and the bicyclo[3.2.1]octanoids 7–10 were isolated along with the known compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f80fb19385810b7d01871456349e0ba
https://doi.org/10.1021/np5008153
https://doi.org/10.1021/np5008153
Autor:
Joel Vega-Rodríguez, Priscilla Krai, Michael Klemba, Kyle Jarrod McLean, Abhai K. Tripathi, Emilio F. Merino, Jessica D. Wiley, Marcelo Jacobs-Lorena, Maria B. Cassera
Publikováno v:
Eukaryotic Cell. 14:128-139
The malaria parasite harbors a relict plastid called the apicoplast and its discovery opened a new avenue for drug discovery and development due to its unusual, nonmammalian metabolism. The apicoplast is essential during the asexual intraerythrocytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::805bc4632ff810f13393b1df863965c9
https://doi.org/10.1128/ec.00198-14
https://doi.org/10.1128/ec.00198-14
Autor:
Emilio F. Merino, Maria L. Fernández-Murga, Daniel J. Slade, Joshua H. Butler, Maria B. Cassera, Rubayet Elahi, Maxim Totrov, Paul R. Carlier, Maryam Ghavami, Priscilla Krai, Zhong-Ke Yao, Morgan Simpson, Michael A. Casasanta
Malaria continues to be one of the deadliest diseases worldwide, and the emergence of drug resistance parasites is a constant threat. Plasmodium parasites utilize the methylerythritol phosphate (MEP) pathway to synthesize isopentenyl pyrophosphate (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec6dbc03b359be1b67c048a3c815b1c
https://europepmc.org/articles/PMC5899049/
https://europepmc.org/articles/PMC5899049/
Autor:
Yongle Du, T. Daniel Crawford, David G. I. Kingston, Seema Dalal, Maria B. Cassera, Kirk C. Pearce, Priscilla Krai, Yumin Dai, Michael Goetz
Publikováno v:
Journal of natural products. 80(5)
A dichloromethane extract of Trichospira verticillata from the Natural Products Discovery Institute was discovered to have good antiplasmodial activity (IC50 ∼5 μg/mL). After purification by liquid–liquid partition and C18 reversed-phase HPLC, f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d90806905417b751f4429738aca248c
https://pubmed.ncbi.nlm.nih.gov/28463001
https://pubmed.ncbi.nlm.nih.gov/28463001