Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

Autor: Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Pascal J. H. Kusters, Susanne M. A. van der Pol, Barbara Zarzycka, Priscilla D. A. M. Heijnen, Linda Beckers, Myrthe den Toom, Marion J. J. Gijbels, Louis Boon, Christian Weber, Helga E. de Vries, Gerry A. F. Nicolaes, Christine D. Dijkstra, Gijs Kooij, Esther Lutgens

Publikováno v: Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-14 (2017)

Abstract Background The influx of leukocytes into the central nervous system (CNS) is a key hallmark of the chronic neuro-inflammatory disease multiple sclerosis (MS). Strategies that aim to inhibit leukocyte migration across the blood-brain barrier

Externí odkaz: https://doaj.org/article/3098d45e563e46008b1ee78f986c3e30

Activation Status of Human Microglia Is Dependent on Lesion Formation Stage and Remyelination in Multiple Sclerosis

Autor: Wouter H. Gerritsen, Paul van der Valk, Sandra Amor, Kimberley Ummenthum, Daphne Y.S. Vogel, Priscilla D. A. M. Heijnen, Laura A. N. Peferoen, Christine D. Dijkstra, Marjolein Breur, Regina Peferoen-Baert

Publikováno v: Journal of Neuropathology and Experimental Neurology, 74(1), 48-63. Lippincott Williams and Wilkins
Peferoen, L A N, Vogel, D Y S, Ummenthum, K, Breur, M, Heijnen, P D A M, Gerritsen, W H, Peferoen-Baert, R M B, van der Valk, P, Dijkstra, C D & Amor, S 2015, ' Activation Status of Human Microglia Is Dependent on Lesion Formation Stage and Remyelination in Multiple Sclerosis ', Journal of Neuropathology and Experimental Neurology, vol. 74, no. 1, pp. 48-63 . https://doi.org/10.1097/NEN.0000000000000149

Similar to macrophages, microglia adopt diverse activation states and contribute to repair and tissue damage in multiple sclerosis. Using reverse transcription-quantitative polymerase chain reaction and immunohistochemistry, we show that in vitro M1-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1780cc193d3fffc34ff8da559fb77337
https://doi.org/10.1097/nen.0000000000000149

Myelin flow cytometry assay detects enhanced levels of antibodies to human whole myelin in a subpopulation of multiple sclerosis patients

Autor: Esther C W Breij, Priscilla D. A. M. Heijnen, Chris H. Polman, Annette van der Goes, Charlotte E. Teunissen, Christine D. Dijkstra

Publikováno v: Breij, E C W, Heijnen, P, van der Goes, A, Teunissen, C E, Polman, C H & Dijkstra, C D 2006, ' Myelin flow cytometry assay detects enhanced levels of antibodies to human whole myelin in a subpopulation of multiple sclerosis patients ', Journal of Neuroimmunology, vol. 176, no. 1-2, pp. 106-114 . https://doi.org/10.1016/j.jneuroim.2006.03.014
Journal of Neuroimmunology, 176(1-2), 106-114. Elsevier

Antibodies directed against myelin components have been described in multiple sclerosis (MS). Accumulating evidence suggests that pathogenically relevant anti-myelin antibodies bind conformational and post-translationally modified epitopes. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d8891a68b53457767ae7a1a5f93aed
https://doi.org/10.1016/j.jneuroim.2006.03.014

GM-CSF promotes migration of human monocytes across the blood brain barrier

Autor: Daphne Y S, Vogel, Gijs, Kooij, Priscilla D A M, Heijnen, Marjolein, Breur, Laura A N, Peferoen, Paul, van der Valk, Helga E, de Vries, Sandra, Amor, Christine D, Dijkstra

Publikováno v: European journal of immunology. 45(6)

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Infiltration of monocytes into the CNS is crucial for disease onset and progression. Animal studies indicate that granulocyte-macrophages col

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e212b862e06cbf86319ecc2028c90a13
https://pubmed.ncbi.nlm.nih.gov/25756873

Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

Autor: Judith E. Glim, E.J.F. Vereyken, Martina Moeton, Charlotte E. Teunissen, Jack van Horssen, Priscilla D. A. M. Heijnen, Sandra Amor, Paul van der Valk, Christine D. Dijkstra, Daphne Y.S. Vogel

Publikováno v: Journal of Neuroinflammation
Vogel, D Y S, Vereyken, E J F, Glim, J E, Heijnen, D A M, Moeton, M, van der Valk, P, Amor, S, Teunissen, C E, van Horssen, J & Dijkstra, C D 2013, ' Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status ', Journal of Neuroinflammation, vol. 10, 35, pp. 35 . https://doi.org/10.1186/1742-2094-10-35
Journal of Neuroinflammation, 10:35. BioMed Central

BackgroundMacrophages play a dual role in multiple sclerosis (MS) pathology. They can exert neuroprotective and growth promoting effects but also contribute to tissue damage by production of inflammatory mediators. The effector function of macrophage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6347146e16f2486529fcaccffd29db8d
https://doi.org/10.1186/1742-2094-10-35