Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Priscilla A. Schaffer"'
Autor:
Steven Haenchen, Thornton W. Thompson, Heba H. Mostafa, Adam M. Bayless, David J. Davido, Anna S. Kushnir, Joshua G. Hilliard, Emma Loveday, Malen A. Link, Priscilla A. Schaffer, Lisa A. Pitcher
Publikováno v:
Journal of Virology. 85:12631-12637
In cell culture experiments, phosphorylation appears to be a critical regulator of the herpes simplex virus 1 (HSV-1) immediate-early (IE) protein, ICP0, which is an E3 ubiquitin ligase that transactivates viral gene expression. Three major regions o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275142413f8d912a5abd02ccd4095de3
https://doi.org/10.1128/jvi.05661-11
https://doi.org/10.1128/jvi.05661-11
Publikováno v:
Journal of Virology. 84:188-200
Herpesviruses are characterized by the ability to establish lifelong latent infections and to reactivate periodically, leading to recurrent disease. The herpes simplex virus type 1 (HSV-1) genome is maintained in a quiescent state in sensory neurons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4632913e7a95220fa08b30c5d65bd6f3
https://doi.org/10.1128/jvi.01377-09
https://doi.org/10.1128/jvi.01377-09
Publikováno v:
Journal of Virology. 83:8733-8743
Of the five herpes simplex virus type 1 immediate early (IE) proteins, the least is known about the function of ICP22 during productive infection and latency. Research characterizing the physical and functional properties of the protein has been limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96247e4947f0e45190bde6f8d6cb795
https://doi.org/10.1128/jvi.00810-09
https://doi.org/10.1128/jvi.00810-09
Autor:
Roger D. Everett, David J. Davido, Chris Boutell, Anne Orr, Priscilla A. Schaffer, Joshua G. Hilliard
Publikováno v:
Journal of Virology. 82:10647-10656
Herpes simplex virus type 1 (HSV-1) infected cell protein 0 (ICP0) is a 110-kDa nuclear phosphoprotein that is required for both the efficient initiation of lytic infection and the reactivation of quiescent viral genomes from latency. The ability of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee75f9d99022a2400c9ffbaca8f211e8
https://doi.org/10.1128/jvi.01063-08
https://doi.org/10.1128/jvi.01063-08
Publikováno v:
Journal of Virology. 81:9175-9182
Although the seven viral proteins required for herpes simplex virus type 1 (HSV-1) DNA replication have been identified, the mechanism by which viral DNA synthesis is regulated is unclear. HSV-1 DNA replication is thought to occur in two stages: orig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9216d854e52e485f542c158387e837
https://doi.org/10.1128/jvi.00676-07
https://doi.org/10.1128/jvi.00676-07
Publikováno v:
Virology. 360:305-321
The host innate response to viral infection includes the production of interferons, which is dependent on the coordinated activity of multiple transcription factors. Herpes simplex virus 1 (HSV-1) has been shown to block efficient interferon expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5dddd2e93af20f72c61cf2a38e1bc51
https://doi.org/10.1016/j.virol.2006.10.028
https://doi.org/10.1016/j.virol.2006.10.028
Publikováno v:
Journal of Virology. 80:4528-4537
This lab reported previously that the plating efficiency of a herpes simplex virus type 1 ICP0-null mutant was enhanced upon release from an isoleucine block which synchronizes cells to G 1 phase (W. Cai and P. A. Schaffer, J. Virol. 65:4078-4090, 19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd3267bf6b49b8b890f8fc29fa4c945
https://doi.org/10.1128/jvi.80.9.4528-4537.2006
https://doi.org/10.1128/jvi.80.9.4528-4537.2006
Autor:
Priscilla A. Schaffer, Donald M. Coen
Publikováno v:
Nature Reviews Drug Discovery. 2:278-288
In the absence of effective vaccines to control herpesvirus infections, nucleosidic antiviral drugs have been the mainstay of clinical treatment since their development in the late 1970s. However, given the drawbacks of these drugs, including the inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c065ec9bde02b4ab14531b17ebaca30
https://doi.org/10.1038/nrd1065
https://doi.org/10.1038/nrd1065
Publikováno v:
Journal of Virology. 76:7724-7735
Herpes simplex virus (HSV) establishes productive (lytic) infections in nonneuronal cells and nonproductive (latent) infections in neurons. It has been proposed that HSV establishes latency because quiescent neurons lack cellular factors required for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da4a017ba31961cef681b82fb983566
https://doi.org/10.1128/jvi.76.15.7724-7735.2002
https://doi.org/10.1128/jvi.76.15.7724-7735.2002
Autor:
Priscilla A. Schaffer, David A. Garber, Donald M. Coen, Lily Y. Lee, David M. Knipe, Shun Hua Chen
Publikováno v:
Journal of Virology. 76:4764-4772
Latent infections by herpes simplex virus are characterized by repression of productive-cycle gene expression. Several hypotheses to explain this repression involve inhibition of expression of the immediate-early gene activator ICP0 during latency. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f45b0edd03f603c623fea127081bc9e3
https://doi.org/10.1128/jvi.76.10.4764-4772.2002
https://doi.org/10.1128/jvi.76.10.4764-4772.2002