Involvement of nuclear factor κB and descending pain pathways in the anti-hyperalgesic effect of β-citronellol, a food ingredient, complexed in β-cyclodextrin in a model of complex regional pain syndrome - Type 1

Autor: João Pedro S. C. F. Matos, Renan G. Brito, Klécia Santos dos Anjos, Yasmim Maria Barbosa Gomes de Carvalho, Thallita Kelly Rabelo, Jackson Roberto Guedes da Silva Almeida, Marlange Almeida Oliveira Melo, Laurent Picot, Paula dos Passos Menezes, Bruno dos Santos Lima, Adriano Antunes de Souza Araújo, Lucindo José Quintans-Júnior, Priscila L. Santos

Publikováno v: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 153

Complex regional pain syndrome type 1 (CRPS-1) is a painful syndrome without effective treatment. In order to explore possible new treatments, we used an animal model of CRPS-1 to examine the effects of β-Citronellol (βCT), a monoterpene found in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3f15cee6fa2bb7f36d4f93215ff81f
https://pubmed.ncbi.nlm.nih.gov/34051299

Evidence for the involvement of TNF-α, IL-1β and IL-10 in the antinociceptive and anti-inflammatory effects of indole-3-guanylhydrazone hydrochloride, an aromatic aminoguanidine, in rodents

Autor: Luana Heimfarth, Paulo Henrique Barcellos França, Jullyana S.S. Quintans, Jean-Jacques Bourguignon, Priscila L. Santos, Gokhan Zengin, Ricardo Luiz Cavalcanti de Albuquerque-Júnior, Martine Schmitt, Silvia M.S. Sandes, Daniele Nascimento Gouveia, Thiago Mendonça de Aquino, João Xavier de Araújo-Júnior, Renan G. Brito, Edeildo Ferreira da Silva-Júnior, Alexandra M.S. Carvalho, Lucindo José Quintans-Júnior

Publikováno v: Chemico-Biological Interactions
Chemico-Biological Interactions, Elsevier, 2018, 286, pp.1-10. ⟨10.1016/j.cbi.2018.02.026⟩

Background Indole-3-guanylhydrazone hydrochloride (LQM01) is a new derivative of aminoguanidine hydrochloride, an aromatic aminoguanidine. Methods Mice were treated with LQM01 (5, 10, 25 or 50 mg/kg, i.p.), vehicle (0.9% saline i.p.) or a standard dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ae4ac6a4862fc9ab82828960a4ce55
https://doi.org/10.1016/j.cbi.2018.02.026

Docking, characterization and investigation of β-cyclodextrin complexed with citronellal, a monoterpene present in the essential oil of Cymbopogon species, as an anti-hyperalgesic agent in chronic muscle pain model

Autor: Renan G. Brito, Priscila L. Santos, Jullyana S.S. Quintans, Henrique Douglas Melo Coutinho, Paula dos Passos Menezes, Irwin Rose Alencar de Menezes, Mairim Russo Serafini, Márcio R. V. Santos, Adriano Antunes de Souza Araújo, Lucindo José Quintans-Júnior, Marlange A. Oliveira, Adriana Gibara Guimarães

Publikováno v: Phytomedicine. 23:948-957

Citronellal (CT) is a monoterpene with antinociceptive acute effect. β-Cyclodextrin (βCD) has enhanced the analgesic effect of various substances.To evaluate the effect of CT both complexed in β-cyclodextrin (CT-βCD) and non-complexed, in a chron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a25d35408d145bfcea3b4550806c4cd
https://doi.org/10.1016/j.phymed.2016.06.007

Evaluation of the orofacial antinociceptive profile of the ethyl acetate fraction and its major constituent, rosmarinic acid, from the leaves of Hyptis pectinata on rodents

Autor: Silvana Alves de Souza, Tania M. S. Silva, Rosângela E.A. Falcão, Priscila L. Santos, Jullyana S.S. Quintans, Lucindo José Quintans-Júnior, Ádley Antonini Neves de Lima, Maria Tereza dos Santos Correia, Celso A. Camara, Adriana Gibara Guimarães

Publikováno v: Revista Brasileira de Farmacognosia, Vol 26, Iss 2, Pp 203-208
Revista Brasileira de Farmacognosia v.26 n.2 2016
Revista Brasileira de Farmacognosia
Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
Revista Brasileira de Farmacognosia, Vol 26, Iss 2, Pp 203-208 (2016)
Revista Brasileira de Farmacognosia, Volume: 26, Issue: 2, Pages: 203-208, Published: APR 2016

Hyptis pectinata (L.) Poit., Lamiaceae, popularly known as “sambacaitá,” is an aromatic shrub largely grown in the Brazilian northeastern. We investigated the antinociceptive effects of the ethyl acetate fraction obtained from the leaves of H. p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a0aadf3228e11fa51e301a5501318e
https://doi.org/10.1016/j.bjp.2015.07.029

Citronellol, a monoterpene alcohol with promising pharmacological activities - A systematic review

Autor: João Pedro S. C. F. Matos, Jackson Roberto Guedes da Silva Almeida, Jullyana S.S. Quintans, Lucindo José Quintans-Júnior, Priscila L. Santos, Laurent Picot

Publikováno v: Food and Chemical Toxicology
Food and Chemical Toxicology, Elsevier, 2019, 123, pp.459-469. ⟨10.1016/j.fct.2018.11.030⟩

International audience; Many diseases, such as inflammatory and central nervous system disorders, currently have a limited number of effective side-effect free treatments. Citronellol (CT) is a monoterpene alcohol present in the essential oil of seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436538372021bf10efc270076f3df07a
https://pubmed.ncbi.nlm.nih.gov/30453001