Rejuvenation by cell reprogramming: a new horizon in gerontology

Autor: Rodolfo G. Goya, Marianne Lehmann, Priscila Chiavellini, Martina Canatelli-Mallat, Claudia B. Hereñú, Oscar A. Brown

Publikováno v: Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-9 (2018)

Abstract The discovery of animal cloning and subsequent development of cell reprogramming technology were quantum leaps as they led to the achievement of rejuvenation by cell reprogramming and the emerging view that aging is a reversible epigenetic p

Externí odkaz: https://doaj.org/article/a50dacf7c9254324bed14bf098025bb8

YOUNG PLASMA REJUVENATES BLOOD DNA METHYLATION PROFILE, PROLONGS MEAN LIFESPAN AND IMPROVES HEALTH IN OLD RATS

Autor: Priscila Chiavellini, Martina Canatelli Mallat, Marianne Lehmann, Joseph A. Zoller, Juozas Gordevicius, Maria D. Gallardo, Diana C. Pasquini, Ezequiel Lacunza, Claudia B. Herenu, Gustavo R. Morel, Steve Horvath, Rodolfo G. Goya

There is converging evidence that young blood conveys cells, vesicles and molecules able to revitalize function and restore organ integrity in old individuals. Here, we assessed the effects of young rat plasma on the lifespan, epigenetic age and heal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::005656ef4435e6bc2f1e1053078f1b04
https://doi.org/10.1101/2022.12.01.518747

Partial Reprogramming As An Emerging Strategy for Safe Induced Cell Generation and Rejuvenation

Autor: Marianne Lehmann, Gloria M. Cónsole, Rodolfo G. Goya, Maria D Gallardo, Martina Canatelli-Mallat, Priscila Chiavellini

Publikováno v: Current Gene Therapy. 19:248-254

Background: Conventional cell reprogramming involves converting a somatic cell line into induced pluripotent stem cells (iPSC), which subsequently can be re-differentiated to specific somatic cell types. Alternatively, partial cell reprogramming conv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa53944558b15a4e7831eb79cb647b4
https://doi.org/10.2174/1566523219666190902154511

Epigenetic predictors of maximum lifespan and other life history traits in mammals

Autor: Caesar Z. Li, Amin Haghani, Todd R. Robeck, Diego Villar, Ake T. Lu, Joshua Zhang, Chris G. Faulkes, Ha Vu, Julia Ablaeva, Danielle M. Adams, Reza Ardehali, Adriana Arneson, C. Scott Baker, Katherine Belov, Daniel T. Blumstein, Eleanor K. Bors, Charles E. Breeze, Robert T. Brooke, Janine L. Brown, Alex Caulton, Julie M. Cavin, Ioulia Chatzistamou, Hao Chen, Priscila Chiavellini, Oi-Wa Choi, Shannon Clarke, Joseph DeYoung, Candice K. Emmons, Stephan Emmrich, Zhe Fei, Steven H. Ferguson, Carrie J. Finno, Jennifer E. Flower, Jean-Michel Gaillard, Eva Garde, Vadim N. Gladyshev, Rodolfo G. Goya, M. Bradley Hanson, Martin Haulena, Kelsey Herrick, Andrew N. Hogan, Carolyn J. Hogg, Timothy A. Hore, Anna J. Jasinska, Gareth Jones, Eve Jourdain, Olga Kashpur, Harold Katcher, Etsuko Katsumata, Vimala Kaza, Hippokratis Kiaris, Michael S. Kobor, Pawel Kordowitzki, William R. Koski, Brenda Larison, Sang-Goo Lee, Marianne Lehmann, Jean-Francois Lemaitre, Andrew J. Levine, Cun Li, Xinmin Li, David TS Lin, Dana M. Lindemann, Nicholas Macoretta, Dewey Maddox, Craig O. Matkin, Julie A. Mattison, June Mergl, Jennifer J. Meudt, Gisele A. Montano, Khyobeni Mozhui, Asieh Naderi, Martina Nagy, Pritika Narayan, Peter W. Nathanielsz, Ngoc B. Nguyen, Christof Niehrs, Duncan T Odom, Alexander G. Ophir, Elaine A. Ostrander, Perrie O'Tierney Ginn, Kim M. Parsons, Kimberly C. Paul, Matteo Pellegrini, Gabriela M. Pinho, Jocelyn Plassais, Natalia A. Prado, Benjamin Rey, Beate R. Ritz, Jooke Robbins, Magdalena Rodriguez, Jennifer Russell, Elena Rydkina, Lindsay L. Sailer, Adam B. Salmon, Akshay Sanghavi, Kyle M. Schachtschneider, Dennis Schmitt, Lars Schomacher, Lawrence B. Schook, Karen E. Sears, Ashley W. Seifert, Anastasia V. Shindyapina, Kavita Singh, Ishani Sinha, Russel G. Snell, Elham Soltanmohammadi, Matthew L. Spangler, Maria Spriggs, Karen J. Steinman, Victoria J. Sugrue, Balazs Szladovits, Masaki Takasugi, Emma C. Teeling, Bill Van Bonn, Sonja C. Vernes, Harry V. Vinters, Mary C. Wallingford, Nan Wang, Gerald S. Wilkinson, Robert W. Williams, X. William Yang, Brent G. Young, Bohan Zhang, Zhihui Zhang, Peng Zhao, Yang Zhao, Wanding Zhou, Joseph A. Zoller, Jason Ernst, Andrei Seluanov, Ken Raj, Vera Gorbunova, Steve Horvath

Maximum lifespan of a species is the oldest that individuals can survive, reflecting the genetic limit of longevity in an ideal environment. Here we report methylation-based models that accurately predict maximum lifespan (r=0.89), gestational time (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fee697f5dd92102b3316fdd9b4d13a89
https://doi.org/10.1101/2021.05.16.444078

Aging and rejuvenation - a modular epigenome model

Autor: Claudia B. Hereñú, Marianne Lehmann, José L. Cordeiro, Rodolfo G. Goya, Martina Canatelli-Mallat, Priscila Chiavellini, Maria D Gallardo, James Clement

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Aging (Albany NY)

The view of aging has evolved in parallel with the advances in biomedical sciences. Long considered as an irreversible process where interventions were only aimed at slowing down its progression, breakthrough discoveries like animal cloning and cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07be1064ac4377731a46f6edf28a71c
http://sedici.unlp.edu.ar/handle/10915/128713