Výsledky vyhledávání - "Prisca Ornaghi"

The bromodomain of Gcn5p interacts in vitro with specific residues in the N terminus of histone H4 1 1Edited by T. Richmond

Autor: Paola Ballario, Anna Maria Lena, Alicia González, Patrizia Filetici, Prisca Ornaghi

Publikováno v: Journal of Molecular Biology. 287:1-7

Whereas the histone acetyltransferase activity of yeast Gcn5p has been widely studied, its structural interactions with the histones and the role of the carboxy-terminal bromodomain are still unclear. Using a glutathione S-transferase pull down assay

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e73ec503c5f1e94ba05110c2b16cb49
https://doi.org/10.1006/jmbi.1999.2577

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Small-Molecule Inhibitors of Histone Acetyltransferase Activity: Identification and Biological Properties

Autor: Antonello Mai, Marco Miceli, Gianluca Sbardella, Caterina Vicidomini, Patrizia Filetici, Prisca Ornaghi, Federica Tosi, Angela Nebbioso, Dante Rotili, Lucia Altucci, Domenico Tarantino

Publikováno v: Journal of medicinal chemistry 16 (2006): 6897–6907. doi:10.1021/jm060601m
info:cnr-pdr/source/autori:Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P,/titolo:Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties./doi:10.1021%2Fjm060601m/rivista:Journal of medicinal chemistry/anno:2006/pagina_da:6897/pagina_a:6907/intervallo_pagine:6897–6907/volume:16

Starting from a yeast phenotypic screening performed on 21 compounds, we described the identification of two small molecules (9 and 18) able to significantly reduce the S. cerevisiae cell growth, thus miming the effect of GCN5 deletion mutant. Tested

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84967a34fd9cf5706f7e6b947535fbb
http://hdl.handle.net/11573/358996

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Gcn5p plays an important role in centromere kinetochore function in budding yeast

Autor: Patrizia Filetici, Paola Ballario, Stefano Vernarecci, Prisca Ornaghi, Enrico Cundari, AnaCristina Bâgu

Publikováno v: Molecular and cellular biology
28 (2008): 988–996. doi:10.1128/MCB.01366-07
info:cnr-pdr/source/autori:Vernarecci S, Ornaghi P, Bâgu A, Cundari E, Ballario P, Filetici P./titolo:Gcn5p plays an important role in centromere kinetochore function in budding yeast/doi:10.1128%2FMCB.01366-07/rivista:Molecular and cellular biology (Print)/anno:2008/pagina_da:988/pagina_a:996/intervallo_pagine:988–996/volume:28

Epigenetic changes and chromatin signaling regulate gene expression by modifying chromatin structure. Multisubunit chromatin complexes reversibly remodel nucleosome organization and act in the catalytic modification of histone N-terminal tails, produ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c18490cded3c4ac919b991b2527c88
http://www.cnr.it/prodotto/i/11540

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The yeast penta-EF protein Pef1p is involved in cation-dependent budding and cell polarization

Autor: Emilia Chiancone, Stefano Vernarecci, Gianni Colotti, Patrizia Filetici, Prisca Ornaghi, Elmar Schiebel

Publikováno v: Molecular microbiology
65 (2007): 1122–1138. doi:10.1111/j.1365-2958.2007.05852.x
info:cnr-pdr/source/autori:Vernarecci S, Colotti G, Ornaghi P, Schiebel E, Chiancone E, Filetici P/titolo:The yeast penta-EF protein Pef1p is involved in cation-dependent budding and cell polarization/doi:10.1111%2Fj.1365-2958.2007.05852.x/rivista:Molecular microbiology (Print)/anno:2007/pagina_da:1122/pagina_a:1138/intervallo_pagine:1122–1138/volume:65

Penta-EF-hand (PEF) proteins bind calcium and participate in a variety of calcium-dependent processes in vertebrates. In yeast, intracellular cations regulate processes like cell division and polarized growth. This study reports the identification of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe12a1f04723bf61682c13eacb029df3
https://pubmed.ncbi.nlm.nih.gov/17640275

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The role of loop ZA and Pro371 in the function of yeast Gcn5p bromodomain revealed through molecular dynamics and experiment

Autor: Francesco Pizzitutti, Giovanni Ciccotti, Andrea Giansanti, Paola Torreri, Paola Ballario, Prisca Ornaghi, Patrizia Filetici

Publikováno v: JMR. Journal of molecular recognition 19 (2005): 1–9. doi:10.1002/jmr.748
info:cnr-pdr/source/autori:Pizzitutti F, Giansanti A, Ballario P, Ornaghi P, Torreri P, Ciccotti G, Filetici P./titolo:The role of loop ZA and Pro371 in the function of yeast Gcn5p bromodomain revealed through molecular dynamics and experiment./doi:10.1002%2Fjmr.748/rivista:JMR. Journal of molecular recognition/anno:2005/pagina_da:1/pagina_a:9/intervallo_pagine:1–9/volume:19
JMR. Journal of molecular recognition 19 (2006): 1–9.
info:cnr-pdr/source/autori:Pizzitutti F, Giansanti A, Ballario P, Ornaghi P, Torreri P, Ciccotti G, Filetici P ./titolo:The role of loop ZA and Pro371 in the function of yeast Gcn5p bromodomain revealed through molecular dynamics and experiment./doi:/rivista:JMR. Journal of molecular recognition/anno:2006/pagina_da:1/pagina_a:9/intervallo_pagine:1–9/volume:19

Biological experiments were combined with molecular dynamics simulations to understand the importance of amino acidic residues present in the bromodomain of the yeast histone acetyltransferase Gcn5p. It was found that residue Pro371 plays an importan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78eec8137d171dba21d388117dbd3d10
http://hdl.handle.net/11573/236256

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A novel Gcn5p inhibitor represses cell growth, gene transcription and histone acetylation in budding yeast

Autor: Patrizia Filetici, Antonello Mai, Dante Rotili, Prisca Ornaghi, Gianluca Sbardella

Histone acetyltransferases are key chromatin regulators responsible for transcriptional activation and cell cycle progression. We propose a simple yeast-based assay to determine the specificity and targets of novel Gcn5p inhibitors. Here, we report t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fcf61373057a1f6e9171fa7e2030c56
http://hdl.handle.net/11386/1059776

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Nanocapsules: coating for living cells

Autor: Raffaella Magrassi, Benedetto Grimaldi, Prisca Ornaghi, A. Gliozzi, Paola Ballario, Alberto Diaspro, Paola Ramoino, Silke Krol, Patrizia Filetici

Publikováno v: IEEE transactions on nanobioscience 3 (2004): 32–38.
info:cnr-pdr/source/autori:Krol S, Diaspro A, Magrassi R, Ballario P, Grimaldi B, Filetici P, Ornaghi P, Ramoino P, Gliozzi A./titolo:Nanocapsules: coating for living cells. /doi:/rivista:IEEE transactions on nanobioscience/anno:2004/pagina_da:32/pagina_a:38/intervallo_pagine:32–38/volume:3

One of the most promising tools for future applications in science and medicine is the use of nanotechnologies. Especially self-assembly systems, e.g., polyelectrolyte (PE) capsules prepared by means of the layer-by-layer technique with tailored prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2046ca7de521ed9f6393e318c479753e
https://pubmed.ncbi.nlm.nih.gov/15382641

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Nanocapsules a novel tool for medicine and science

Autor: Alessandra Gliozzi, Davide Cavanna, Paola Ballario, Prisca Ornaghi, Silke Krol, Ornella Cavalleri, Benedetto Grimaldi, Alberto Diaspro, Patrizia Filetici

Publikováno v: Frontiers of Multifunctional Integrated Nanosystems ISBN: 1402021712

The most promising tool for future applications in the field of science as well as in medicine is the use of nanotechnologies. Especially self-assembly systems with tailored properties on a nanometer level fulfil the requirements to nano-organized sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23ed8c49b5fc8dfa97e12e4c604dff1
http://hdl.handle.net/11573/148301

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