Correction: Immunological non-response and low hemoglobin levels are predictors of incident tuberculosis among HIV-infected individuals on Truvada-based therapy in Botswana.

Autor: Lucy Mupfumi, Sikhulile Moyo, Kesaobaka Molebatsi, Prisca K Thami, Motswedi Anderson, Tuelo Mogashoa, Thato Iketleng, Joseph Makhema, Richard Marlink, Ishmael Kasvosve, Max Essex, Rosemary M Musonda, Simani Gaseitsiwe

Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0198711 (2018)

[This corrects the article DOI: 10.1371/journal.pone.0192030.].

Externí odkaz: https://doaj.org/article/0382a10ebf4d4dd4be7fa83c0c558510

Whole genome sequencing reveals population diversity and variation in HIV-1 specific host genes

Autor: Prisca K. Thami, Wonderful T. Choga, Collet Dandara, Stephen J. O’Brien, Myron Essex, Simani Gaseitsiwe, Emile R. Chimusa

Publikováno v: Frontiers in Genetics, Vol 14 (2023)

HIV infection continues to be a major global public health issue. The population heterogeneity in susceptibility or resistance to HIV-1 and progression upon infection is attributable to, among other factors, host genetic variation. Therefore, identif

Externí odkaz: https://doaj.org/article/81eba73213784e279e6a6832680e1247

The role of CYP2B6 516GT polymorphism on efavirenz/nevirapine toxicity. Implications on treatment outcomes: Lessons from Botswana

Autor: Monkgomotsi J. Maseng, Leabaneng Tawe, Prisca K. Thami, Sikhulile Moyo, Ishmael Kasvosve, Vladimir Novitsky, Max Essex, Gianluca Russo, Simani Gaseitsiwe, Giacomo M. Paganotti

Publikováno v: Medicine. 101(17)

The two non-nucleoside reverse transcriptase inhibitors (NNRTIs), efavirenz (EFV) and nevirapine (NVP), are currently the core antiretroviral drugs for treatment of HIV in sub-Saharan Africa including Botswana. The drugs are metabolized by Cytochrome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c7f3ff4fbcd5c809f875fc805685cf
https://pubmed.ncbi.nlm.nih.gov/35512066

Genome-wide association study reveals genetic variants associated with HIV-1C infection in a Botswana study population

Autor: Simani Gaseitsiwe, David Vlahov, Anastasiia Turenko, Vladimir Novitsky, Myron Essex, Alexey Antonik, Stephen J. O'Brien, Igor Evsyukov, Sergey Kliver, Daria V. Zhernakova, Gaik Tamazian, Sergey V. Malov, Mikhail Rotkevich, Alexey Komissarov, Nikolay Cherkasov, Prisca K Thami, Sofia M Kolchanova, Andrey Shevchenko

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 118(47):e2107830118. NATL ACAD SCIENCES
Proc Natl Acad Sci U S A

Although there have been many studies of gene variant association with different stages of HIV/AIDS progression in United States and European cohorts, few gene-association studies have assessed genic determinants in sub-Saharan African populations, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea160c4e24f8e5a40a227fb8442346d4
https://research.rug.nl/en/publications/8fdbcd47-5ccf-4092-ac8e-657ddfb6b7bb

Association of CYP2B6 Genetic Variation with Efavirenz and Nevirapine Drug Resistance in HIV-1 Patients from Botswana

Autor: Vladimir Novitsky, Giacomo Maria Paganotti, Leabaneng Tawe, Simani Gaseitsiwe, Ishmael Kasvosve, Sikhulile Moyo, Axel Martinelli, Monkgomotsi J Maseng, Gianluca Russo, Kaelo K Seatla, Prisca K Thami, Max Essex

Publikováno v: Pharmacogenomics and Personalized Medicine

Monkgomotsi J Maseng,1,2 Leabaneng Tawe,1– 3 Prisca K Thami,2,4 Kaelo K Seatla,1,2 Sikhulile Moyo,2,5 Axel Martinelli,6 Ishmael Kasvosve,1 Vladimir Novitsky,2,5 Max Essex,2,5 Gianluca Russo,7 Simani Gaseitsiwe,2,5 Giacomo M Paganotti3,8,9 1School o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932055dd71d4962910abc290aa6d63c3
http://hdl.handle.net/11573/1524841