Zobrazeno 1 - 10
of 508
pro vyhledávání: '"Priority Research Paper"'
Publikováno v:
Aging (Albany NY)
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key glycolytic enzyme that participates in various cellular events, such as DNA repair and apoptosis. The functional diversity of GAPDH depends on its intracellular localization. Because AMP-activ
Publikováno v:
Aging (Albany NY)
Palikaras, K, Achanta, K, Choi, S, Akbari, M & Bohr, V A 2021, ' Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy ', Aging, vol. 13, no. 21, pp. 23876-23894 . https://doi.org/10.18632/aging.203683
Palikaras, K, Achanta, K, Choi, S, Akbari, M & Bohr, V A 2021, ' Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy ', Aging, vol. 13, no. 21, pp. 23876-23894 . https://doi.org/10.18632/aging.203683
Tauopathies are a group of progressive neurodegenerative disorders characterized by the presence of insoluble intracellular tau filaments in the brain. Evidence suggests that there is a tight connection between mitochondrial dysfunction and tauopathi
Autor:
Michael E. Mullendore, Deborah Wilsker, Anne Monks, Melinda G. Hollingshead, Lara H. El Touny, Sergio Y. Alcoser, Angie B. Dull, Curtis Hose, Erik Harris, Michelle M. Gottholm-Ahalt, Annamaria Rapisarda, Beverly A. Teicher, Ralph E. Parchment, James H. Doroshow, John Connelly
Publikováno v:
Oncotarget
The therapeutic efficacy of temozolomide (TMZ) is hindered by inherent and acquired resistance. Biomarkers such as MGMT expression and MMR proficiency are used as predictors of response. However, not all MGMTlow/−ve/MMRproficient patients benefit f
Publikováno v:
Aging (Albany NY)
Aging, 13 (19)
Aging, 13 (19)
Green tea catechins are associated with a delay in aging. We have designed the current study to investigate the impact and to unveil the target of the most abundant green tea catechins, epigallocatechin gallate (EGCG) and epicatechin gallate (ECG). E
Autor:
Wafik S. El-Deiry, Shuai Zhao
Publikováno v:
Oncotarget
The major adaptive response to hypoxia involves hypoxia-inducible factor HIF-1α which is regulated by von Hippel Lindau (VHL) E3 ligase. We previously observed a stabilization of HIF-1α by cyclin-dependent kinases CDK1 and CDK4/6 that is independen
Autor:
Jair Machado Espindola-Netto, Utkarsh Tripathi, Tamar Pirtskhalava, Konstantin Maria Johannes Sparrer, Nino Giorgadze, Stephanie L. Dickinson, Ailing Xue, Laura J. Niedernhofer, Larissa G.P. Langhi Prata, Frank Kirchhoff, Rayhane Nchioua, Paul D. Robbins, Erin O. Wissler Gerdes, David B. Allison, Yi Zhu, Steffen Stenger, Erik S. Parker, James L. Kirkland, Tamar Tchkonia
Publikováno v:
Aging (Albany NY)
Senescent cells, which arise due to damage-associated signals, are apoptosis-resistant and can express a pro-inflammatory, tissue-destructive senescence-associated secretory phenotype (SASP). We recently reported that a component of the severe acute
Autor:
Yang Yang, Sahana Manohar-Sindhu, Thomas C. Foster, Daohong Zhou, Dmitry O. Traktuev, Yonghan He, Vivekananda Budamagunta
Publikováno v:
Aging (Albany NY)
Aging is associated with an increased susceptibility to adverse inflammatory conditions such as sepsis and cytokine storm. We hypothesized that senescent cells (SnCs) play a central role in this age-associated pathology in part due to their expressio
Autor:
Natalay Kouprina, Marie-Paule Teulade-Fichou, Yves Pommier, N. S. Petrov, Vladimir Larionov, Mikhail Liskovykh, William C. Earnshaw, Hee-Sheung Lee, Hiroshi Masumoto
Publikováno v:
Petrov, N S, Lee, H-S, Liskovykh, M, Teulade-Fichou, M-P, Masumoto, H, Earnshaw, W C, Pommier, Y, Larionov, V & Kouprina, N 2021, ' Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells ', Oncotarget, vol. 12, pp. 1444-1456 . https://doi.org/10.18632/oncotarget.28020
Oncotarget
Oncotarget
Background Telomerase/telomere-targeting therapy is a potentially promising approach for cancer treatment because even transient telomere dysfunction can induce chromosomal instability (CIN) and may be a barrier to tumor growth. Method: We recently d
Autor:
Poonam R. Pandey, Vijay R. Varma, Carlos Anerillas, Myriam Gorospe, Allison B. Herman, Jennifer L. Martindale, Dimitrios Tsitsipatis, Martina Rossi, Rachel Munk, Madhav Thambisetty, Jen-Hao Yang, Kotb Abdelmohsen, Jackson A. Roberts
Publikováno v:
Aging (Albany NY)
Cellular senescence is linked to chronic age-related diseases including atherosclerosis, diabetes, and neurodegeneration. Compared to proliferating cells, senescent cells express distinct subsets of proteins. In this study, we used cultured human dip
Autor:
Samuel G Cockey, Chang-Yi Cui, Ji Heon Noh, Yongqing Zhang, Elin Lehrmann, Jen-Hao Yang, Marc Michel, Yulan Piao, Linda K. Krasniewski, Riley K Driscoll, Myriam Gorospe
Publikováno v:
Aging (Albany NY)
GRSF1 is a mitochondrial RNA-binding protein important for maintaining mitochondrial function. We found that GRSF1 is highly expressed in cultured skeletal myoblasts differentiating into myotubes. To understand the physiological function of GRSF1 in