Zobrazeno 1 - 10
of 2 014
pro vyhledávání: '"Prion-like"'
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 6423-6439 (2024)
Neurodegeneration is becoming one of the leading causes of death worldwide as the population expands and grows older. There is a growing desire to understand the mechanisms behind prion proteins as well as the prion-like proteins that make up neurode
Externí odkaz:
https://doaj.org/article/99ba7402254f47f7bacc8058bd737e6b
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e34963- (2024)
Pathological proteins in amyotrophic lateral sclerosis (ALS), such as superoxide dismutase 1, TAR DNA-binding protein 43, and fused in sarcoma, exhibit a prion-like pattern. All these proteins have a low-complexity domain and seeding activity in cell
Externí odkaz:
https://doaj.org/article/6b5ee03cf07d4e779529d92086d38a65
Autor:
Peisong Wu, Yihao Li
Publikováno v:
Plants, Vol 13, Iss 18, p 2666 (2024)
Prion–like domains (PrLDs), a unique type of low–complexity domain (LCD) or intrinsically disordered region (IDR), have been shown to mediate protein liquid–liquid phase separation (LLPS). Recent research has increasingly focused on how prion
Externí odkaz:
https://doaj.org/article/2ce938544d534492b8ae67b54df2aff1
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
BackgroundNatural cases of prion disease have not been reported in rabbits, and prior attempts to identify a prion conversion agent have been unsuccessful. However, recent applications of prion seed amplifying experimental techniques have sparked ren
Externí odkaz:
https://doaj.org/article/2e8ab6d84a734e55b80ee0cef94b9597
Autor:
Neelam Younas, Saima Zafar, Tayyaba Saleem, Leticia Camila Fernandez Flores, Abrar Younas, Matthias Schmitz, Inga Zerr
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Background Aberrant stress granules (SGs) are emerging as prime suspects in the nucleation of toxic protein aggregates. Understanding the molecular networks linked with aggregation-prone proteins (prion protein, synuclein, and tau) under str
Externí odkaz:
https://doaj.org/article/ae784e4048cf4683997f67b8926ae885
Autor:
Tajamul H. Mir, Parvaiz A Zargar, Alok Sharma, Bushra Jabeen, Shephali Sharma, M. Omar Parvaiz, Sabah Bashir, Reem Javeed
Publikováno v:
Prion, Vol 17, Iss 1, Pp 111-115 (2023)
ABSTRACTCoronavirus disease 2019 (COVID-19) pandemic has taken the world by a storm, posing a gruelling challenge to the medical fraternity globally. Besides its very high infectivityinfectivity, significant organ dysfunction occurs in critically ill
Externí odkaz:
https://doaj.org/article/d7cb674072e24a06984e050e40338553
Autor:
Anastasia Bougea
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10783 (2024)
Multiple system atrophy and Lewy body diseases (LBDs) such as Parkinson’s disease, dementia with Lewy bodies, and Parkinson’s disease with dementia, known as synucleinopathies, are defined neuropathologically by the accumulation and deposition of
Externí odkaz:
https://doaj.org/article/eff1fe27d8964bd9a28c4621e70aa390
Publikováno v:
Heliyon, Vol 10, Iss 4, Pp e26260- (2024)
Breast cancer (BC) is viewed as a significant public health issue and is the primary cause of cancer-related deaths among women worldwide. Triple-negative breast cancer (TNBC) is a particularly aggressive subtype that predominantly affects young prem
Externí odkaz:
https://doaj.org/article/d2b3aada06e44327b29bff0937937283
Autor:
Aurelien Lathuiliere, Youhwa Jo, Romain Perbet, Cameron Donahue, Caitlin Commins, Noé Quittot, Zhanyun Fan, Rachel E. Bennett, Bradley T. Hyman
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-13 (2023)
Abstract Background The prion-like propagation of tau in neurodegenerative disorders implies that misfolded pathological tau can recruit the normal protein and template its aggregation. Here, we report the methods for the development of sensitive bio
Externí odkaz:
https://doaj.org/article/fc15df3efa934d16963e5ff8c35d1c47
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
The relative polymerization of specific tau protein cores that define Alzheimer’s disease, Pick’s disease and corticobasal degeneration were investigated using amyloid fluorometry and electron microscopy. In addition, the relative prion-like acti
Externí odkaz:
https://doaj.org/article/b413ab9c9f46455582f9daf1d13b5d1d