Zobrazeno 1 - 10
of 14 672
pro vyhledávání: '"Prion Protein"'
Autor:
Marcus Pehar, Melissa Hewitt, Ashley Wagner, Jagdeep K. Sandhu, Aria Khalili, Xinyu Wang, Jae-Young Cho, Valerie L. Sim, Marianna Kulka
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Although the cellular prion protein (PrPC) has been evolutionarily conserved, the role of this protein remains elusive. Recent evidence indicates that PrPC may be involved in neuroinflammation and the immune response in the brain, and its ex
Externí odkaz:
https://doaj.org/article/1b4485451402458084379f27d1897893
Autor:
Sachiko Koyama, Kaoru Yagita, Hideomi Hamasaki, Hideko Noguchi, Masahiro Shijo, Kosuke Matsuzono, Kei-Ichiro Takase, Keita Kai, Shin-Ichi Aishima, Kyoko Itoh, Toshiharu Ninomiya, Naokazu Sasagasako, Hiroyuki Honda
Publikováno v:
Prion, Vol 18, Iss 1, Pp 40-53 (2024)
ABSTRACTPrion disease is an infectious and fatal neurodegenerative disease. Western blotting (WB)-based identification of proteinase K (PK)-resistant prion protein (PrPres) is considered a definitive diagnosis of prion diseases. In this study, we aim
Externí odkaz:
https://doaj.org/article/88736088322f420ebc3eef6459d81384
Publikováno v:
Неврология, нейропсихиатрия, психосоматика, Vol 16, Iss 4, Pp 68-75 (2024)
This article presents a clinical case of Gerstmann–Sträussler–Scheinker syndrome (GSS) – a progressive inherited prion disease with an extremely rare phenotype that changed dynamically during the course of the disease and eventually led to the
Externí odkaz:
https://doaj.org/article/b4cd9b80f3394588a08c657c27d40836
Autor:
Jiapu Zhang
Publikováno v:
Zoonotic Diseases, Vol 4, Iss 3, Pp 187-200 (2024)
Prion diseases, also called transmissible spongiform encephalopathies (TSEs), are fatal neurodegenerative diseases characterised by the accumulation of an abnormal prion protein isoform (PrPSc: rich in β-sheets—about 30% α-helix and 43% β-sheet)
Externí odkaz:
https://doaj.org/article/16704a3fb3b24a7a9e28a5ec9af7a1e8
Publikováno v:
Advanced Science, Vol 11, Iss 38, Pp n/a-n/a (2024)
Abstract Endometriosis, a chronic inflammatory disease, significantly impairs the quality of life of women in their reproductive years; however, its pathogenesis remains poorly understood. The accumulation of retrograde menstruation and recurrent ble
Externí odkaz:
https://doaj.org/article/a8de1040935f47d48354f1a5ae485283
Autor:
Nhat T. Le, Nam Chu, Gunjan Joshi, Nicole R. Higgins, Ouada Nebie, Niyi Adelakun, Marie Butts, Mervyn J. Monteiro
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106674- (2024)
Mutations in UBQLN2 cause ALS and frontotemporal dementia (FTD). The pathological signature in UBQLN2 cases is deposition of highly unusual types of inclusions in the brain and spinal cord that stain positive for UBQLN2. However, what role these incl
Externí odkaz:
https://doaj.org/article/8e414948803a44938210bc398f21c0fd
Autor:
Ken-Ichi Irie, Hiroyuki Honda, Takahisa Tateishi, Shinichiro Mori, Akifumi Yamamoto, Makoto Morimitsu, Kikuchi Shinsuke, Taiga Moritaka, Seiji Kurata, Hiroyuki Kumazoe, Masahiro Shijo, Naokazu Sasagasako, Takayuki Taniwaki
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Gerstmann–Sträussler–Scheinker (GSS) disease is an inherited prion disease characterized by dementia, cerebellar ataxia, and painful sensory disturbances. GSS is pathologically defined by the presence of amyloid plaques comprised of prion protei
Externí odkaz:
https://doaj.org/article/9f7c8a738af94856b686ac08f2456bf6
Autor:
Sophie Mouillet-Richard, Angélique Gougelet, Bruno Passet, Camille Brochard, Delphine Le Corre, Caterina Luana Pitasi, Camille Joubel, Marine Sroussi, Claire Gallois, Julien Lavergne, Johan Castille, Marthe Vilotte, Nathalie Daniel-Carlier, Camilla Pilati, Aurélien de Reyniès, Fatima Djouadi, Sabine Colnot, Thierry André, Julien Taieb, Jean-Luc Vilotte, Béatrice Romagnolo, Pierre Laurent-Puig
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background The mesenchymal subtype of colorectal cancer (CRC), associated with poor prognosis, is characterized by abundant expression of the cellular prion protein PrPC, which represents a candidate therapeutic target. How PrPC is induced i
Externí odkaz:
https://doaj.org/article/6c482fe7bb844cb5b3a5a20ec371350b
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-6 (2024)
Abstract Background Human prion diseases (HPDs) are fatal neurodegenerative disorders characterized by abnormal prion proteins (PrPSc). However, the detection of prion seeding activity in patients with high sensitivity remains challenging. Even thoug
Externí odkaz:
https://doaj.org/article/6ee4f0328538451e844c80be03009587
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