Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Princy Prasad"'
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Erythropoietic response is controlled not only by erythropoietin but also by iron. In addition to its role in iron delivery, transferrin also functions as a signaling molecule, with effects on both iron homeostasis and erythropoiesis. We investigated
Externí odkaz:
https://doaj.org/article/24c4782170d246eb9f94133b1811c669
Lobe specificity of iron binding to transferrin modulates murine erythropoiesis and iron homeostasis
Autor:
Faris Ali, Edvinas Vaicikauskas, Robert E. Fleming, Yelena Ginzburg, Amaliris Guerra, Carla Casu, Maria Feola, Luke Mammen, Nermi L. Parrow, Yihang Li, Stefano Rivella, Princy Prasad
Publikováno v:
Blood
Transferrin, the major plasma iron-binding molecule, interacts with cell-surface receptors to deliver iron, modulates hepcidin expression, and regulates erythropoiesis. Transferrin binds and releases iron via either or both of 2 homologous lobes (N a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34fe3622fad94013f80bc95278d43c2
https://europepmc.org/articles/PMC6839954/
https://europepmc.org/articles/PMC6839954/
Autor:
Yelena Ginzburg, Tomas Ganz, Carla Casu, Erika V. Valore, Elizabeta Nemeth, Yatrik M. Shah, Vijay Nandi, Princy Prasad, Brian MacDonald, Paraskevi Rea Oikonomidou, Stefano Rivella, Robert E. Fleming, Huiyong Chen
Publikováno v:
Blood. 128:265-276
In β-thalassemia and polycythemia vera (PV), disordered erythropoiesis triggers severe pathophysiological manifestations. β-Thalassemia is characterized by ineffective erythropoiesis, reduced production of erythrocytes, anemia, and iron overload an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a50935dcbc6d0e9022ea9115ba48f4e
https://doi.org/10.1182/blood-2015-10-676742
https://doi.org/10.1182/blood-2015-10-676742
Publikováno v:
Blood. 126:948-948
Nutritional fasting is associated with hypoferremia; however serum iron parameters otherwise differ from those observed with dietary iron deficiency. Activation of the hepcidin gene via the transcription factor CREB-H has been implicated in inducing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa020287e644a6818a9a55bc4bcb475f
https://doi.org/10.1182/blood.v126.23.948.948
https://doi.org/10.1182/blood.v126.23.948.948
Publikováno v:
Blood. 126:947-947
Atoh8 is a member of the bHLH transcription factor family, and hepatic expression of atoh8 mRNA is up-regulated by dietary iron and down-regulated by stimulation of erythropoiesis in mice, in parallel with changes in hepcidin mRNA(hamp1). It is a can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::699b40122ebb82cbbfa4e24e2578a1b9
https://doi.org/10.1182/blood.v126.23.947.947
https://doi.org/10.1182/blood.v126.23.947.947