Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Princesca Dorsaint"'
Autor:
Kyrillus S. Shohdy, Rohan Bareja, Michael Sigouros, David C. Wilkes, Princesca Dorsaint, Jyothi Manohar, Daniel Bockelman, Jenny Z. Xiang, Rob Kim, Kentaro Ohara, Kenneth Eng, Juan Miguel Mosquera, Olivier Elemento, Andrea Sboner, Alicia Alonso, Bishoy M. Faltas
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-10 (2021)
Abstract The availability of fresh frozen (FF) tissue is a barrier for implementing RNA sequencing (RNA-seq) in the clinic. The majority of clinical samples are stored as formalin-fixed, paraffin-embedded (FFPE) tissues. Exome capture platforms have
Externí odkaz:
https://doaj.org/article/be290d96afc142fb9fcbd3a2e94604c7
Autor:
Michelle Naidoo, Fayola Levine, Tamara Gillot, Akintunde T. Orunmuyi, E. Oluwabunmi Olapade-Olaopa, Thahmina Ali, Konstantinos Krampis, Chun Pan, Princesca Dorsaint, Andrea Sboner, Olorunseun O. Ogunwobi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
High mortality rates of prostate cancer (PCa) are associated with metastatic castration-resistant prostate cancer (CRPC) due to the maintenance of androgen receptor (AR) signaling despite androgen deprivation therapies (ADTs). The 8q24 chromosomal lo
Externí odkaz:
https://doaj.org/article/ab3542ca5b4d45b59773c8e50ee96a04
Autor:
José, Jessurun, Christine, Orr, Samantha N, McNulty, Catherine E, Hagen, Hussein, Alnajar, David, Wilkes, Sarah, Kudman, Majd, Al Assaad, Princesca, Dorsaint, Kentaro, Ohara, Feng, He, Kenrry, Chu, Yong Mei, Yin, Jenny Zhaoying, Xiang, Lihui, Qin, Andrea, Sboner, Olivier, Elemento, Rhonda K, Yantiss, Rondell P, Graham, Flora, Poizat, Juan Miguel, Mosquera
Publikováno v:
American Journal of Surgical Pathology. 47:65-73
GLI1 encodes a transcription factor that targets cell cycle regulators affecting stem cell proliferation. GLI1 gene fusions were initially described in pericytomas with a t[7;12] translocation and more recently in gastric plexiform fibromyxomas and g
Autor:
Samuel F. Bakhoum, Benjamin Izar, Eileen E. Parkes, Alexander N. Shoushtari, Charles Swanton, Olivier Elemento, Jedd D. Wolchok, Simon N. Powell, Neil Vasan, Anusha Kalbasi, Shin-San Michael Su, Nadeem Riaz, Jorge S. Reis-Filho, Hannah Y. Wen, Taha Merghoub, Travis J. Hollmann, Benjamin J. DiPardo, Lee Gottesdiener, Chantal Pauli, Peng Li, Julie-Ann Cavallo, Princesca Dorsaint, Maria Laura Martin, Hao Wei Li, Rohan Bareja, Dhruva Biswas, Ieva Usaite, Kevin Litchfield, Sreeram Vallabhaneni, Johannes C. Melms, Matthew G. Hanna, Jacqueline A. James, Manuel Salto-Tellez, Matthew P. Humphries, Roshan K. Sriram, John Kwon, Sarah E. Bettigole, Walid K. Chatila, Ninjit Dhanota, Mercedes A. Duran, Jun Li
Supplementary Figures and Methods in PDF format
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635ea996437975f580871317155e428c
https://doi.org/10.1158/2159-8290.22540268.v1
https://doi.org/10.1158/2159-8290.22540268.v1
Autor:
Samuel F. Bakhoum, Benjamin Izar, Eileen E. Parkes, Alexander N. Shoushtari, Charles Swanton, Olivier Elemento, Jedd D. Wolchok, Simon N. Powell, Neil Vasan, Anusha Kalbasi, Shin-San Michael Su, Nadeem Riaz, Jorge S. Reis-Filho, Hannah Y. Wen, Taha Merghoub, Travis J. Hollmann, Benjamin J. DiPardo, Lee Gottesdiener, Chantal Pauli, Peng Li, Julie-Ann Cavallo, Princesca Dorsaint, Maria Laura Martin, Hao Wei Li, Rohan Bareja, Dhruva Biswas, Ieva Usaite, Kevin Litchfield, Sreeram Vallabhaneni, Johannes C. Melms, Matthew G. Hanna, Jacqueline A. James, Manuel Salto-Tellez, Matthew P. Humphries, Roshan K. Sriram, John Kwon, Sarah E. Bettigole, Walid K. Chatila, Ninjit Dhanota, Mercedes A. Duran, Jun Li
Cytosolic DNA is characteristic of chromosomally unstable metastatic cancer cells, resulting in constitutive activation of the cGAS–STING innate immune pathway. How tumors co-opt inflammatory signaling while evading immune surveillance remains unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af51a233154e60a4e2bb2d77e8270d96
https://doi.org/10.1158/2159-8290.c.6549335
https://doi.org/10.1158/2159-8290.c.6549335
Autor:
Princesca Dorsaint, John D. Carpten, Endale Gebregzabher, Timothy Chu, Andrea Sboner, Nicolas Robine, Lee D. Gibbs, Melissa Davis, Kanika Arora, Olivier Elemento, Rachel Martini, Lisa A. Newman, Zarko Manojlovic
Publikováno v:
Cancer Research. 81:SS1-07
Background: Triple-negative breast cancer (TNBC) remains the most aggressive molecular subtype of breast cancer, with worse survival outcomes compared to other breast cancer subtypes. TNBC prevalence is highest among women of African descent worldwid
Autor:
Johannes C. van der Mijn, Qiuying Chen, Kristian B. Laursen, Francesca Khani, Xiaofei Wang, Princesca Dorsaint, Andrea Sboner, Steven S. Gross, David M. Nanus, Lorraine J. Gudas
Publikováno v:
Molecular carcinogenesis. 61(9)
Research has shown extensive metabolic remodeling in clear cell renal cell carcinoma (ccRCC), with increased glutathione (GSH) levels. We hypothesized that activating transcription factor-4 (ATF4) and the integrated stress response (ISR) induce a met
Autor:
Juan Miguel Mosquera, Jyothi Manohar, Andrea Sboner, Michael Sigouros, Rob Kim, Bishoy Faltas, David Wilkes, Kentaro Ohara, Kenneth Eng, Princesca Dorsaint, Rohan Bareja, Olivier Elemento, Jenny Xiang, Daniel Bockelman, Alicia Alonso, Kyrillus S. Shohdy
Publikováno v:
NPJ Genomic Medicine
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-10 (2021)
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-10 (2021)
The availability of fresh frozen (FF) tissue is a barrier for implementing RNA sequencing (RNA-seq) in the clinic. The majority of clinical samples are stored as formalin-fixed, paraffin-embedded (FFPE) tissues. Exome capture platforms have been deve
Autor:
Renuka Raman, Jacques A. Villefranc, Timothy M. Ullmann, Jessica Thiesmeyer, Viviana Anelli, Jun Yao, James R. Hurley, Chantal Pauli, Rohan Bareja, Kenneth Wha Eng, Princesca Dorsaint, David C. Wilkes, Shaham Beg, Sarah Kudman, Reid Shaw, Michael Churchill, Adnan Ahmed, Laurel Keefer, Ian Misner, Donna Nichol, Naveen Gumpeni, Theresa Scognamiglio, Mark A. Rubin, Carla Grandori, James Patrick Solomon, Wei Song, Juan Miguel Mosquera, Noah Dephoure, Andrea Sboner, Olivier Elemento, Yariv Houvras
Publikováno v:
Raman, Renuka; Villefranc, Jacques A; Ullmann, Timothy M; Thiesmeyer, Jessica; Anelli, Viviana; Yao, Jun; Hurley, James R; Pauli, Chantal; Bareja, Rohan; Wha Eng, Kenneth; Dorsaint, Princesca; Wilkes, David C; Beg, Shaham; Kudman, Sarah; Shaw, Reid; Churchill, Michael; Ahmed, Adnan; Keefer, Laurel; Misner, Ian; Nichol, Donna; ... (2022). Inhibition of FGF receptor blocks adaptive resistance to RET inhibition in CCDC6-RET-rearranged thyroid cancer. Journal of experimental medicine, 219(6) Rockefeller University Press 10.1084/jem.20210390
Genetic alterations in RET lead to activation of ERK and AKT signaling and are associated with hereditary and sporadic thyroid cancer and lung cancer. Highly selective RET inhibitors have recently entered clinical use after demonstrating efficacy in
Autor:
Princesca Dorsaint, Robert Kim, Alicia Alonso, Olivier Elemento, Jyothi Manohar, Michael Sigouros, David Wilkes, Jenny Xiang, D. Bockelman, Andrea Sboner, Juan Miguel Mosquera, Rohan Bareja, Bishoy Faltas, Kyrillus S. Shohdy
BackgroundThe need for fresh frozen (FF) tissue limits implementing RNA sequencing (RNA-seq) in the clinic. The majority of clinical samples are processed in clinical laboratories and stored as formalin-fixed, paraffin-embedded (FFPE) tissues. Exome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dc692f223f12fb4423efa0969ea171a
https://doi.org/10.1101/2021.01.24.21250395
https://doi.org/10.1101/2021.01.24.21250395