Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Prince J Kannankeril"'
Autor:
Allison J. Weatherly, MD, Cassandra A. Johnson, MS, Dandan Liu, PhD, Prince J. Kannankeril, MD, MSCI, Heidi A.B. Smith, MD, MSCI, FAAP, Kristina A. Betters, MD
Publikováno v:
Critical Care Explorations, Vol 6, Iss 7, p e1119 (2024)
OBJECTIVE:. ICU delirium commonly complicates critical illness associated with factors such as cardiopulmonary bypass (CPB) time and the requirement of mechanical ventilation (MV). Recent reports associate hyperoxia with poorer outcomes in critically
Externí odkaz:
https://doaj.org/article/a3e492835f584a11830f0227d8cc3d18
Autor:
Megan J. Puckelwartz, Lorenzo L. Pesce, Edgar J. Hernandez, Gregory Webster, Lisa M. Dellefave-Castillo, Mark W. Russell, Sarah S. Geisler, Samuel D. Kearns, Felix Karthik, Susan P. Etheridge, Tanner O. Monroe, Tess D. Pottinger, Prince J. Kannankeril, M. Benjamin Shoemaker, Darlene Fountain, Dan M. Roden, Meghan Faulkner, Heather M. MacLeod, Kristin M. Burns, Mark Yandell, Martin Tristani-Firouzi, Alfred L. George, Elizabeth M. McNally
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Background Sudden unexpected death in children is a tragic event. Understanding the genetics of sudden death in the young (SDY) enables family counseling and cascade screening. The objective of this study was to characterize genetic variatio
Externí odkaz:
https://doaj.org/article/754c31b062b14f8fb5738e1f18f62142
Autor:
Sara L Van Driest, Tracy L McGregor, Digna R Velez Edwards, Ben R Saville, Terrie E Kitchner, Scott J Hebbring, Murray Brilliant, Hayan Jouni, Iftikhar J Kullo, C Buddy Creech, Prince J Kannankeril, Susan I Vear, Kyle B Brothers, Erica A Bowton, Christian M Shaffer, Neelam Patel, Jessica T Delaney, Yuki Bradford, Sarah Wilson, Lana M Olson, Dana C Crawford, Amy L Potts, Richard H Ho, Dan M Roden, Josh C Denny
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127791 (2015)
Vancomycin, a commonly used antibiotic, can be nephrotoxic. Known risk factors such as age, creatinine clearance, vancomycin dose / dosing interval, and concurrent nephrotoxic medications fail to accurately predict nephrotoxicity. To identify potenti
Externí odkaz:
https://doaj.org/article/d1b2a61fcf654975a0b71ba96a9457bc
Autor:
Eric L. Eisenstein, Kevin D. Hill, Nancy Wood, Jerry L. Kirchner, Kevin J. Anstrom, Christopher B. Granger, Sunil V. Rao, H. Scott Baldwin, Jeffrey P. Jacobs, Marshall L. Jacobs, Prince J. Kannankeril, Eric M. Graham, Sean M. O'Brien, Jennifer S. Li
Publikováno v:
Contemporary Clinical Trials Communications, Vol 38, Iss , Pp 101257- (2024)
Background: Registry-based trials have the potential to reduce randomized clinical trial (RCT) costs. However, observed cost differences also may be achieved through pragmatic trial designs. A systematic comparison of trial costs across different des
Externí odkaz:
https://doaj.org/article/7912ef2ef50e4a909f9255670edbac5b
Autor:
Elijah R Behr, Marylyn D Ritchie, Toshihiro Tanaka, Stefan Kääb, Dana C Crawford, Paola Nicoletti, Aris Floratos, Moritz F Sinner, Prince J Kannankeril, Arthur A M Wilde, Connie R Bezzina, Eric Schulze-Bahr, Sven Zumhagen, Pascale Guicheney, Nanette H Bishopric, Vanessa Marshall, Saad Shakir, Chrysoula Dalageorgou, Steve Bevan, Yalda Jamshidi, Rachel Bastiaenen, Robert J Myerburg, Jean-Jacques Schott, A John Camm, Gerhard Steinbeck, Kris Norris, Russ B Altman, Nicholas P Tatonetti, Steve Jeffery, Michiaki Kubo, Yusuke Nakamura, Yufeng Shen, Alfred L George, Dan M Roden
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78511 (2013)
Marked prolongation of the QT interval on the electrocardiogram associated with the polymorphic ventricular tachycardia Torsades de Pointes is a serious adverse event during treatment with antiarrhythmic drugs and other culprit medications, and is a
Externí odkaz:
https://doaj.org/article/3e85dcfe215d421eb42dff29deda650d
Autor:
Aleksandra Polic, MD, Stacy A.S. Killen, MD, MSCI, Janette F. Strasburger, MD, Prince J. Kannankeril, MD, MSCI, Ronald T. Wakai, PhD, Soha S. Patel, MD, MSPH
Publikováno v:
JACC: Case Reports, Vol 29, Iss 3, Pp 102183- (2024)
A low baseline fetal heart rate at 20 weeks’ gestation was detected in a fetus without cardiac structural anomalies. Fetal echocardiography and magnetocardiography were used to diagnose congenital long QT syndrome. It was confirmed in the neonate,
Externí odkaz:
https://doaj.org/article/354f972781f04be78996603f2c6f53b7
Autor:
Sudeep D. Sunthankar, Prince J. Kannankeril, Andrea Gaedigk, Andrew E. Radbill, Frank A. Fish, Sara L. Van Driest
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 7, Pp 1787-1795 (2022)
Abstract Propafenone is an antiarrhythmic drug metabolized primarily by cytochrome P450 2D6 (CYP2D6). In adults, propafenone adverse events (AEs) are associated with CYP2D6 poor metabolizer status; however, pediatric data are lacking. Subjects were t
Externí odkaz:
https://doaj.org/article/6026c7e303044f3babf4a37c9394b561
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Atrial fibrillation (AF) is the most common human arrhythmia and is associated with increased risk of stroke, dementia, heart failure, and death. Among several animal models that have been used to investigate the molecular determinants of AF, mouse m
Externí odkaz:
https://doaj.org/article/ef7c31c6489b4e488f970b79020cb8d4
Autor:
Kevin R. Bersell, Tao Yang, Jonathan D. Mosley, Andrew M. Glazer, Andrew T. Hale, Dmytro O. Kryshtal, Kyungsoo Kim, Jeffrey D. Steimle, Jonathan D. Brown, Joe-Elie Salem, Courtney C. Campbell, Charles C. Hong, Quinn S. Wells, Amanda N. Johnson, Laura Short, Marcia A. Blair, Elijah R. Behr, Evmorfia Petropoulou, Yalda Jamshidi, Mark D. Benson, Michelle J. Keyes, Debby Ngo, Ramachandran S. Vasan, Qiong Yang, Robert E. Gerszten, Christian Shaffer, Shan Parikh, Quanhu Sheng, Prince J. Kannankeril, Ivan P. Moskowitz, John D. York, Thomas J. Wang, Bjorn C. Knollmann, Dan M. Roden
Publikováno v:
Circulation. 147:824-840
Background: Brugada syndrome (BrS) is an inherited arrhythmia syndrome caused by loss-of-function variants in the cardiac sodium channel gene SCN5A (sodium voltage-gated channel alpha subunit 5) in ≈20% of subjects. We identified a family with 4 in
Autor:
Kevin D, Hill, Prince J, Kannankeril, Jeffrey P, Jacobs, H Scott, Baldwin, Marshall L, Jacobs, Sean M, O'Brien, David P, Bichel, Eric M, Graham, Brian, Blasiole, Ashraf, Resheidat, Adil S, Husain, S Ram, Kumar, Jerry L, Kirchner, Dianne S, Gallup, Joseph W, Turek, Mark, Bleiweis, Bret, Mettler, Alexis, Benscoter, Eric, Wald, Tara, Karamlou, Andrew H, Van Bergen, David, Overman, Pirooz, Eghtesady, Ryan, Butts, John S, Kim, John P, Scott, Brett R, Anderson, Michael F, Swartz, Patrick I, McConnell, David F, Vener, Jennifer S, Li, Kimberly, Teknipp
Publikováno v:
N Engl J Med
BACKGROUND: Although perioperative prophylactic glucocorticoids have been used for decades, whether they improve outcomes in infants after heart surgery with cardiopulmonary bypass is unknown. METHODS: We conducted a multicenter, prospective, randomi