Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Prince, L.R."'
Autor:
Herman, K.D., Wright, C.G., Marriott, H.M., McCaughran, S.C., Bowden, K.A., Collins, M.O., Renshaw, S.A., Prince, L.R.
Dysregulated neutrophilic inflammation can be highly destructive in chronic inflammatory diseases due to prolonged neutrophil lifespan and continual release of histotoxic mediators in inflamed tissues. Therapeutic induction of neutrophil apoptosis, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::1bcbb3c9541d8851b3319cdca7aa3562
https://eprints.whiterose.ac.uk/189737/1/fimmu-13-956991.pdf
https://eprints.whiterose.ac.uk/189737/1/fimmu-13-956991.pdf
How multifunctional cells such as macrophages interpret the different cues within their environment and undertake an appropriate response is a key question in developmental biology. Understanding how cues are prioritized is critical to answering this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::95d67dc26cb4871ca7965999f2801ac9
https://eprints.whiterose.ac.uk/173039/1/fcell-09-636024.pdf
https://eprints.whiterose.ac.uk/173039/1/fcell-09-636024.pdf
Autor:
Isles, H.M., Herman, K.D., Robertson, A.L., Loynes, C.A., Prince, L.R., Elks, P.M., Renshaw, S.A.
Publikováno v:
Frontiers in Immunology
The inappropriate retention of neutrophils at inflammatory sites is a major driver of the excessive tissue damage characteristic of respiratory inflammatory diseases including COPD, ARDS, and cystic fibrosis. The molecular programmes which orchestrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::1ef757309de185cad310e7162f774bff
https://eprints.whiterose.ac.uk/149445/1/fimmu-10-01784.pdf
https://eprints.whiterose.ac.uk/149445/1/fimmu-10-01784.pdf
Autor:
Iqbal, A., Prince, L.R., Novodvorsky, P., Bernjak, A., Thomas, M.R., Birch, L., Lambert, D., Kay, L.J., Wright, F.J., Macdonald, I.A., Jacques, R.M., Storey, R.F., McCrimmon, R.J., Francis, S., Heller, S.R., Sabroe, I.
Context: Hypoglycemia is emerging as a risk for cardiovascular events in diabetes. We hypothesized that hypoglycemia activates the innate immune system, which is known to increase cardiovascular risk. Objective: To determine whether hypoglycemia modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::0c74a2e48beb2ca6ca76bb0ac5068613
https://eprints.whiterose.ac.uk/137220/8/jc.2018-01168.pdf
https://eprints.whiterose.ac.uk/137220/8/jc.2018-01168.pdf
Staphylococcus aureus is a commensal organism in approximately 30% of the human population and colonization is a significant risk factor for invasive infection. As a result of this, there is a great need to better understand how S. aureus overcomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::c91a51eb296db52f9c18255c70a5b369
Staphylococcus aureus is a human commensal but also has devastating potential as an opportunist pathogen. S. aureus bacteraemia is often associated with an adverse outcome. To identify potential targets for novel control approaches we have identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::f0ac01441b4bc43df6aa637e0b1dfb6e
Autor:
Alsharif, K.F., Thomas, M.R., Judge, H.M., Khan, H., Prince, L.R., Sabroe, I., Ridger, V.C., Storey, R.F.
In the PLATO study, ticagrelor was associated with fewer pulmonary infections and subsequent deaths than clopidogrel. Neutrophils are a first-line defence against bacterial lung infection; ticagrelor inhibits cellular uptake of adenosine, a known reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::73723d42576e30993044d9938d0ca343
https://eprints.whiterose.ac.uk/106386/1/1-s2.0-S1537189115000439-main.pdf
https://eprints.whiterose.ac.uk/106386/1/1-s2.0-S1537189115000439-main.pdf
Autor:
Prince, L.R., Maxwell, N.C., Gill, S.K., Dockrell, D.H., Sabroe, I., McGreal, E.P., Kotecha, S., Whyte, M.K.
Publikováno v:
PLoS One
The etiology of persistent lung inflammation in preterm infants with chronic lung disease of prematurity (CLD) is poorly characterized, hampering efforts to stratify prognosis and treatment. Airway macrophages are important innate immune cells with r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::fa237af856277a4f00ae894f6d210c88
https://eprints.whiterose.ac.uk/80562/1/WRRO_80562.pdf
https://eprints.whiterose.ac.uk/80562/1/WRRO_80562.pdf
Autor:
Basran, A., Jabeen, M., Bingle, L., Stokes, C.A., Dockrell, D.H., Whyte, M.K.B., Walmsley, S.R., Higgins, K.R., Vogel, S.N., Wilson, H.L., Prince, L.R., Prestwich, E.C., Sabroe, R.A., Parker, L.C., Sabroe, I.
This study examined the establishment of neutrophilic inflammation in humans. We tested the hypotheses that neutrophil recruitment was associated with local CXCL8 production and that neutrophils themselves might contribute to the regulation of the si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::00fcff7a95e8de12f0456adcd5713493
Autor:
Prince, L.R., Graham, K.J., Connolly, J., Anwar, S., Ridley, R., Sabroe, I., Foster, S.J., Whyte, M.K.B.
Staphylococcus aureus, a major human pathogen, exacerbates allergic disorders, including atopic dermatitis, nasal polyps\ud and asthma, which are characterized by tissue eosinophilia. Eosinophils, via their destructive granule contents, can cause\ud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::118c2750f40ce7e6c3b463052f106bd6