Zobrazeno 1 - 10
of 691
pro vyhledávání: '"Primosome"'
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 588 (2022)
Single-stranded DNA (ssDNA)-binding protein (SSB) plays a crucial role in DNA replication, repair, and recombination as well as replication fork restarts. SSB is essential for cell survival and, thus, is an attractive target for potential antipathoge
Externí odkaz:
https://doaj.org/article/27fab970933e460b96a4b4048d0f8bc9
Akademický článek
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Autor:
Steven W. Hardwick, Amir Guppy, Charlotte E. Veale, Neil J. Rzechorzek, Mairi L. Kilkenny, Luca Pellegrini, Joseph D. Maman, Dimitri Y. Chirgadze
Publikováno v:
Protein Science : A Publication of the Protein Society
The molecular mechanisms that drive the infection by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)—the causative agent of coronavirus disease 2019 (COVID‐19)—are under intense current scrutiny to understand how the virus
Autor:
Hui Yin Tan, Piero R. Bianco
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 25, Pp 16324-16335 (2021)
ACS Omega, Vol 6, Iss 25, Pp 16324-16335 (2021)
Primosomal protein A (PriA) is a member of helicase SuperFamily 2. Its role in vivo is to reload the primosome onto resurrected replication forks resulting in the restart of the previously stalled DNA replication process. Single-stranded DNA-binding
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10854, p 10854 (2021)
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10854, p 10854 (2021)
PriB is a primosomal protein required for the replication fork restart in bacteria. Although PriB shares structural similarity with SSB, they bind ssDNA differently. SSB consists of an N-terminal ssDNA-binding/oligomerization domain (SSBn) and a flex
Publikováno v:
Journal of Biological Chemistry. 294:2801-5614
DNA helicases are motor proteins that couple the chemical energy of nucleoside triphosphate hydrolysis to the mechanical functions required for DNA unwinding. Studies of several helicases have identified strand-separating “pin” structures that ar
Publikováno v:
EMBO J
The intricate process of human mtDNA replication requires the coordinated action of both transcription and replication machineries. Transcription and replication events at the lagging strand of mtDNA prompt the formation of a stem-loop structure (Ori
Autor:
Amir Guppy, Joseph D. Maman, Dimitri Y. Chirgadze, Mairi L. Kilkenny, Luca Pellegrini, Steven W. Hardwick, Charlotte E. Veale, Neil J. Rzechorzek
The molecular mechanisms that drive the infection by the SARS-CoV-2 coronavirus – the causative agent of the COVID-19 (Coronavirus disease-2019) pandemic – are under intense current scrutiny, to understand how the virus operates and to uncover wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80d377025352b24a318d9b33399613f8
https://doi.org/10.1101/2021.06.17.448816
https://doi.org/10.1101/2021.06.17.448816
Publikováno v:
J Phys Chem B
The DNA helicase PriA is a key protein for restarting stalled DNA replication forks in bacteria. With 3′ to 5′ helicase activity, PriA is important in primosome assembly. We used atomic force microscopy (AFM) and specifically employed time-lapse
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1867:367-375
When the replisome collapses at a DNA damage site, a sequence-independent replication restart system is required. In Escherichia coli, PriA, PriB, and DnaT assemble in an orderly fashion at the stalled replication fork and achieve the reloading of th