High-throughput screening of clinically approved drugs that prime nonviral gene delivery to human Mesenchymal stem cells

Autor: Tyler Kozisek, Andrew Hamann, Albert Nguyen, Michael Miller, Sarah Plautz, Angela K. Pannier

Publikováno v: Journal of Biological Engineering, Vol 14, Iss 1, Pp 1-13 (2020)

Abstract Background Human mesenchymal stem cells (hMSCs) are intensely researched for applications in cell therapeutics due to their unique properties, however, intrinsic therapeutic properties of hMSCs could be enhanced by genetic modification. Vira

Externí odkaz: https://doaj.org/article/e99851574ce744b8b5947170d7b0f092

High‐throughput screening of clinically approved drugs that prime polyethylenimine transfection reveals modulation of mitochondria dysfunction response improves gene transfer efficiencies

Autor: Jared Beyersdorf, Angela K. Pannier, Albert Nguyen, Jean-Jack M Riethoven

Publikováno v: Bioengineering & Translational Medicine

Nonviral gene delivery methods are advantageous over viral vectors in terms of safety, cost, and flexibility in design and application, but suffer from lower gene transfer efficiency. In addition to modifications to nucleic acid design and nonviral c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5762fd92e87bde42a339bc3fcff06e
http://europepmc.org/articles/PMC5127179

High-throughput screening of clinically approved drugs that prime polyethylenimine transfection reveals modulation of mitochondria dysfunction response improves gene transfer efficiencies.

Autor: Nguyen A; Dept. of Biological Systems Engineering University of Nebraska-Lincoln Lincoln NE 68583; Center for Nanohybrid Functional Materials University of Nebraska-Lincoln, Lincoln NE 68588; Dept. of Electrical and Computer Engineering University of Nebraska-Lincoln Lincoln NE 68588., Beyersdorf J; Dept. of Biological Systems Engineering University of Nebraska-Lincoln Lincoln NE 68583., Riethoven JJ; Bioinformatics Core Research Facility University of Nebraska-Lincoln Lincoln NE 68588; School of Biological Sciences University of Nebraska-Lincoln, Lincoln NE 68588., Pannier AK; Dept. of Biological Systems Engineering University of Nebraska-Lincoln Lincoln NE 68583; Center for Nanohybrid Functional Materials University of Nebraska-Lincoln, Lincoln NE 68588.

Publikováno v: Bioengineering & translational medicine [Bioeng Transl Med] 2016 Jun; Vol. 1 (2), pp. 123-135. Date of Electronic Publication: 2016 Jul 21.