Zobrazeno 1 - 10
of 1 221
pro vyhledávání: '"Primary human hepatocytes"'
Autor:
Huangfan Xie, Guangya Li, Yunxi Fu, Nan Jiang, Simeng Yi, Xi Kong, Jihang Shi, Shigang Yin, Jianhua Peng, Yong Jiang, Shichun Lu, Hongkui Deng, Bingqing Xie
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background Primary human hepatocytes (PHHs) are highly valuable for drug-metabolism evaluation, liver disease modeling and hepatocyte transplantation. However, their availability is significantly restricted due to limited donor sources, alon
Externí odkaz:
https://doaj.org/article/96fcbdc0735b4138afb414fad8ac0c42
Autor:
Lena Seidemann, Clara Paula Lippold, Carolin Marie Rohm, Julian Connor Eckel, Gerda Schicht, Madlen Matz-Soja, Thomas Berg, Daniel Seehofer, Georg Damm
Publikováno v:
BMC Endocrine Disorders, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is higher in men than in women. Hormonal and genetic causes may account for the sex differences in MASLD. Current human in vitro liver models do not su
Externí odkaz:
https://doaj.org/article/5680678d7d2a4fa2b5fc85ac45d171db
Autor:
Suhyun Hwangbo, Gahee Kim, Yongwook Choi, Yong Kwang Park, Songmee Bae, Jae Yong Ryu, Wonhee Hur
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract Background Chronic hepatitis B virus (HBV) infection affects around 250 million people worldwide, causing approximately 887,000 deaths annually, primarily owing to cirrhosis and hepatocellular carcinoma (HCC). The current approved treatments
Externí odkaz:
https://doaj.org/article/53455c747cfc461dbb5003e01f5a7052
Autor:
Florentin Pastor, Emilie Charles, Lucid Belmudes, Hélène Chabrolles, Marion Cescato, Michel Rivoire, Thomas Burger, Guillaume Passot, David Durantel, Julie Lucifora, Yohann Couté, Anna Salvetti
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Phosphorylation is a major post-translation modification (PTM) of proteins which is finely tuned by the activity of several hundred kinases and phosphatases. It controls most if not all cellular pathways including anti-viral responses. Accordingly, v
Externí odkaz:
https://doaj.org/article/3bbead2920a8416c931a889020d4c95f
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-29 (2023)
Abstract Background Xenobiotics are primarily metabolized by hepatocytes in the liver, and primary human hepatocytes are the gold standard model for the assessment of drug efficacy, safety, and toxicity in the early phases of drug development. Recent
Externí odkaz:
https://doaj.org/article/6a8da7ef286c4c96aed02998d51eb792
Autor:
Nicholas van Eijk, Luna C. Schmacke, Torsten Steinmetzer, Oliver Pilgram, Miklós Poór, Erzsébet Pászti-Gere
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115761- (2023)
The outbreak of coronavirus disease 2019 (COVID-19) pandemic strongly stimulated the development of small molecule antivirals selectively targeting type II transmembrane serine proteases (TTSP), required for the host-cell entry of numerous viruses. A
Externí odkaz:
https://doaj.org/article/2cba99daeb6c428d8c10277c3f18aaa3
Autor:
Lena Seidemann, Sarah Prinz, Jan-Constantin Scherbel, Christina Götz, Daniel Seehofer, Georg Damm
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 22, Pp 12-34 (2023)
Loss of differentiation of primary human hepatocytes (PHHs) ex vivo is a known problem of in vitro liver models. Culture optimizations using collagen type I and Matrigel reduce the dedifferentiation process but are not able to prevent it. While neith
Externí odkaz:
https://doaj.org/article/5f95ff161ca144f4a00a505c7521d57a
Autor:
Chuanhai Li, Lidan Jiang, Yuan Qi, Donghui Zhang, Xinya Liu, Wenchao Han, Wanli Ma, Lin Xu, Yuan Jin, Jiao Luo, Kunming Zhao, Dianke Yu
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 249, Iss , Pp 114361- (2023)
Perfluorooctane sulfonate (PFOS) and its alternative 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA) are ubiquitous in various environmental and human samples. They have been reported to have hepatotoxicity effects, but the potential m
Externí odkaz:
https://doaj.org/article/dac78adc25c84133aa2d9be820e4a916
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