Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.

Autor: Smith BM; Arena Pharmaceuticals Inc., 6166 Nancy Ridge Drive, San Diego, California 92121, USA. bsmith@arenapharm.com, Smith JM, Tsai JH, Schultz JA, Gilson CA, Estrada SA, Chen RR, Park DM, Prieto EB, Gallardo CS, Sengupta D, Dosa PI, Covel JA, Ren A, Webb RR, Beeley NR, Martin M, Morgan M, Espitia S, Saldana HR, Bjenning C, Whelan KT, Grottick AJ, Menzaghi F, Thomsen WJ

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2008 Jan 24; Vol. 51 (2), pp. 305-13. Date of Electronic Publication: 2007 Dec 21.