Insights into spheroids formation in cellulose nanofibrils and Matrigel hydrogels using AFM-based techniques

Autor: Teixeira Polez, Roberta, Huynh, Ngoc, Pridgeon, Chris S., Valle-Delgado, Juan José, Harjumäki, Riina, Österberg, Monika

Publikováno v: In Materials Today Bio June 2024 26

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In Vivo Tumorigenicity of the 20q11.21 Amplicon in an Engraftment Model of hPSCs and Differentiated Liver Cells

Autor: Pridgeon, Chris S., Forootan, Shiva Seyed, Zhang, Fang, Harper, Nicholas, Palmer, Daniel, Weightmann, Richard, Gregory, Sian, Hewitt, Zoe, Baker, Duncan, Halliwell, Jason, Moore, Harry, Ricci, Emanuele, Andrews, Peter W., Poptani, Harish, Hay, David C., Park, B. Kevin, Goldring, Chris E. P.

Publikováno v: J Stem Cells Regen Med

Human pluripotent stem cells (hPSCs) are a promising source of somatic cells for clinical applications and disease modelling. However, during culture they accumulate genetic aberrations such as amplification of 20q11.21 which occurs in approximately

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38ac0613c44b5f9638346a12271dfe65
https://europepmc.org/articles/PMC10290816/

CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload

Autor: Harjumäki, Riina, Pridgeon, Chris S., Ingelman-Sundberg, Magnus

CYP2E1 is one of the fifty-seven cytochrome P450 genes in the human genome and is highly conserved. CYP2E1 is a unique P450 enzyme because its heme iron is constitutively in the high spin state, allowing direct reduction of, e.g., dioxygen, causing t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1593::4bef7b8e024495c94aba3ef5d5155dbd
http://hdl.handle.net/10138/333308

MicroRNA-122: A Novel Hepatocyte-Enriched in vitro Marker of Drug-Induced Cellular Toxicity

Autor: Kia, Richard, Kelly, Lorna, Sison-Young, Rowena L C, Zhang, Fang, Pridgeon, Chris S, Heslop, James A, Metcalfe, Pete, Kitteringham, Neil R, Baxter, Melissa, Harrison, Sean, Hanley, Neil A, Burke, Zoë D, Storm, Mike P, Welham, Melanie J, Tosh, David, Küppers-Munther, Barbara, Edsbagge, Josefina, Starkey Lewis, Philip J, Bonner, Frank, Harpur, Ernie, Sidaway, James, Bowes, Joanne, Fenwick, Stephen W, Malik, Hassan, Goldring, Chris E P, Park, B Kevin

Publikováno v: Toxicological Sciences
Kia, R, Kelly, L, Sison-Young, R L C, Zhang, F, Pridgeon, C S, Heslop, J A, Metcalfe, P, Kitteringham, N R, Baxter, M, Harrison, S, Hanley, N A, Burke, Z D, Storm, M P, Welham, M J, Tosh, D, Küppers-Munther, B, Edsbagge, J, Starkey Lewis, P J, Bonner, F, Harpur, E, Sidaway, J, Bowes, J, Fenwick, S W, Malik, H, Goldring, C E P & Park, B K 2015, ' MicroRNA-122 : a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity ', Toxicological Sciences, vol. 144, no. 1, pp. 173-85 . https://doi.org/10.1093/toxsci/kfu269

Emerging hepatic models for the study of drug-induced toxicity include pluripotent stem cell-derived hepatocyte-like cells (HLCs) and complex hepatocyte-non-parenchymal cellular coculture to mimic the complex multicellular interactions that recapitul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cd7a2e08d09da1ee421bb8a12388c678
http://europepmc.org/articles/PMC4349141