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pro vyhledávání: '"Pricilla Richberg"'
Autor:
Mayra B. Reyes, Simon Leung, Zenrong Gao, Theo Denzel, Chiajen Lai, Jack Z. Gougoutas, Mark Lindrud, Kevin J. Volk, Thomas P. Kissick, Victor W. Rosso, Gerard A. Crispino, Wei Meng, Pricilla Richberg, Prashant P. Deshpande, William N. Washburn, Mueller Richard H, David Hughes, Hidegard Lobinger, Renee Randazzo, Peter Hans Ermann, Michael E. Randazzo, Wendel W. Doubleday, Michael Fakes, Annie Pullockaran, Frederic G. Buono, Bruce A. Ellsworth, Janak Singh, John D. Dimarco
Publikováno v:
Organic Process Research & Development. 16:577-585
A practical synthesis of the SGLT-2 inhibitor β-C-aryl-d-glucoside (1) has been developed. The route employed 2,3,4,6-tetra-O-trimethlysilyl-d-glucano-1,5-lactone as the key chiral building block, prepared efficiently from the commercially available