Zobrazeno 1 - 10
of 864
pro vyhledávání: '"Price, Theodore"'
Plasticity in dorsal root ganglion (DRG) neurons that promotes pain requires activity-dependent mRNA translation. Protein synthesis inhibitors block the ability of many pain-promoting molecules to enhance excitability in DRG neurons and attenuate beh
Externí odkaz:
http://hdl.handle.net/10150/627082
http://arizona.openrepository.com/arizona/handle/10150/627082
http://arizona.openrepository.com/arizona/handle/10150/627082
Autor:
Moy, Jamie K., Khoutorsky, Arkady, Asiedu, Marina N., Black, Bryan J., Kuhn, Jasper L., Barragán-Iglesias, Paulino, Megat, Salim, Burton, Michael D., Burgos-Vega, Carolina C., Melemedjian, Ohannes K., Boitano, Scott, Vagner, Josef, Gkogkas, Christos G., Pancrazio, Joseph J., Mogil, Jeffrey S., Dussor, Gregory, Sonenberg, Nahum, Price, Theodore J.
Injury-induced sensitization of nociceptors contributes to pain states and the development of chronic pain. Inhibiting activity-dependent mRNA translation through mechanistic target of rapamycin and mitogen-activated protein kinase (MAPK) pathways bl
Externí odkaz:
http://hdl.handle.net/10150/625494
http://arizona.openrepository.com/arizona/handle/10150/625494
http://arizona.openrepository.com/arizona/handle/10150/625494
Autor:
Asiedu, Marina N., Han, Chongyang, Dib-Hajj, Sulayman D., Waxman, Stephen G., Price, Theodore J., Dussor, Gregory
Voltage-gated sodium channels (VGSC) regulate neuronal excitability by governing action potential (AP) generation and propagation. Recent studies have revealed that AMP-activated protein kinase (AMPK) activators decrease sensory neuron excitability,
Externí odkaz:
http://hdl.handle.net/10150/623094
http://arizona.openrepository.com/arizona/handle/10150/623094
http://arizona.openrepository.com/arizona/handle/10150/623094
Autor:
Melemedjian, Ohannes, Tillu, Dipti, Moy, Jamie, Asiedu, Marina, Mandell, Edward, Ghosh, Sourav, Dussor, Gregory, Price, Theodore
Transcriptional regulation of genes by cyclic AMP response element binding protein (CREB) is essential for the maintenance of long-term memory. Moreover, retrograde axonal trafficking of CREB in response to nerve growth factor (NGF) is critical for t
Externí odkaz:
http://hdl.handle.net/10150/610222
http://arizona.openrepository.com/arizona/handle/10150/610222
http://arizona.openrepository.com/arizona/handle/10150/610222
Autor:
Price, Theodore, Ghosh, Sourav
Chronic pain remains a significant clinical problem despite substantial advances in our understanding of how persistent nociceptor stimulation drives plasticity in the CNS. A major theme that has emerged in this area of work is the strong similarity
Externí odkaz:
http://hdl.handle.net/10150/610219
http://arizona.openrepository.com/arizona/handle/10150/610219
http://arizona.openrepository.com/arizona/handle/10150/610219
BACKGROUND:Peripheral nerve injury (PNI) results in a fundamental reorganization of the translational machinery in the injured peripheral nerve such that protein synthesis is increased in a manner linked to enhanced mTOR and ERK activity. We have sho
Externí odkaz:
http://hdl.handle.net/10150/610218
http://arizona.openrepository.com/arizona/handle/10150/610218
http://arizona.openrepository.com/arizona/handle/10150/610218
Autor:
Melemedjian, Ohannes, Tillu, Dipti, Asiedu, Marina, Mandell, Edward, Moy, Jamie, Blute, Victoria, Taylor, Caleb, Ghosh, Sourav, Price, Theodore
BACKGROUND:Chronic pain is an important medical problem affecting hundreds of millions of people worldwide. Mechanisms underlying the maintenance of chronic pain states are poorly understood but the elucidation of such mechanisms have the potential t
Externí odkaz:
http://hdl.handle.net/10150/610217
http://arizona.openrepository.com/arizona/handle/10150/610217
http://arizona.openrepository.com/arizona/handle/10150/610217
Autor:
David, Eric T., Yousuf, Muhammad Saad, Mei, Hao-Ruei, Jain, Ashita, Krishnagiri, Sharada, Elahi, Hajira, Venkatesan, Rupali, Srikanth, Kolluru D., Dussor, Gregory, Dalva, Matthew B., Price, Theodore J.
Publikováno v:
In Pharmacological Research August 2024 206
Autor:
Mitchell, Molly E., Torrijos, Gema, Cook, Lauren F., Mwirigi, Juliet M., He, Lucy, Shiers, Stephanie, Price, Theodore J.
Publikováno v:
In Neurobiology of Pain July-December 2024 16
BACKGROUND:Migraine headache is one of the most common neurological disorders, but the pathophysiology contributing to migraine is poorly understood. Intracranial interleukin-6 (IL-6) levels have been shown to be elevated during migraine attacks, sug
Externí odkaz:
http://hdl.handle.net/10150/610216
http://arizona.openrepository.com/arizona/handle/10150/610216
http://arizona.openrepository.com/arizona/handle/10150/610216