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pro vyhledávání: '"Prevo R"'
Targeting TOPK 1 sensitises tumour cells to radiation-induced damage by enhancing replication stress
T-LAK-originated protein kinase (TOPK) overexpression is a feature of multiple cancers, yet is absent from most phenotypically normal tissues. As such, TOPK expression profiling and the development of TOPK-targeting pharmaceutical agents have raised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1064::ceaaf893d3eb70d11714751e9b60c826
https://ora.ox.ac.uk/objects/uuid:56ca0e9a-15bc-460c-b2e3-cbe4e483395d
https://ora.ox.ac.uk/objects/uuid:56ca0e9a-15bc-460c-b2e3-cbe4e483395d
Akademický článek
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Autor:
McGowan, D, Skwarski, M, Bradley, K, Campo, L, Fenwick, J, Gleeson, F, Green, M, Horne, A, Maughan, T, McCole, M, Mohammed, S, Muschel, R, Ng, S, Panakis, N, Prevo, R, Strauss, V, Stuart, R, Tacconi, E, Vallis, K, McKenna, W, Macpherson, R, Higgins, G
Publikováno v:
European journal of cancer (Oxford, England : 1990)
EUROPEAN JOURNAL OF CANCER
EUROPEAN JOURNAL OF CANCER
Background\udPre-clinically, phosphoinositide 3-kinase (PI3K) inhibition radiosensitises tumours by increasing intrinsic radiosensitivity and by reducing tumour hypoxia. We assessed whether buparlisib, a class 1 PI3K inhibitor, can be safely combined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::16c33e885cf6d183ca26e4fa34718fe7
https://orca.cardiff.ac.uk/id/eprint/131982/1/PIIS0959804919302126.pdf
https://orca.cardiff.ac.uk/id/eprint/131982/1/PIIS0959804919302126.pdf
Autor:
Prevo, R., Ranzani, M., Puliyadi, R., Rodriguez-Berriguete, G., Robinson, H., Rajendra, E., Grinkevich, V., Boursier, M., Cicconi, A., Piscitello, D., Cerutti, A., Majithiya, J., Heald, R., Stockley, M., Smith, G., Higgins, G.
Publikováno v:
In Radiotherapy and Oncology May 2022 170 Supplement 1:S371-S372
Publikováno v:
In Radiotherapy and Oncology May 2022 170 Supplement 1:S113-S114
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 9, Iss 11, Pp 1-10 (2018)
Cell Death and Disease, Vol 9, Iss 11, Pp 1-10 (2018)
‘Targeted’ or ‘biological’ cancer treatments rely on differential gene expression between normal tissue and cancer, and genetic changes that render tumour cells especially sensitive to the agent being applied. Problems exist with the applicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d517c7780fcfcf3b0acda301da9403f5
https://ora.ox.ac.uk/objects/uuid:586e4a8d-e902-4d11-941e-ee361b3e3d8f
https://ora.ox.ac.uk/objects/uuid:586e4a8d-e902-4d11-941e-ee361b3e3d8f
Autor:
Rodriguez-Berriguete, G, Granata, G, Puliyadi, R, Tiwana, G, Prevo, R, Wilson, R, Yu, S, Buffa, F, Humphrey, T, McKenna, W, Higgins, G
Publikováno v:
Nucleic Acids Research
The nuclear pore complex (NPC) machinery is emerging as an important determinant in the maintenance of genome integrity and sensitivity to DNA double-strand break (DSB)-inducing agents, such as ionising radiation (IR). In this study, using a high-thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a6f6f974259439c5bee8e601b4e4bc95
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Publikováno v:
Cancer Biology and Therapy. 18(6)
The identification of genetic determinants that underpin tumor radioresistance can help the development of targeted radiosensitizers or aid personalization of radiotherapy treatment. Here we identify signal recognition particle 72kDa (SRP72) as a nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e812087484900eb55563fa4316436f8d
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Akademický článek
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Autor:
Kato, T.1,2 t-kato@bd5.so-net.ne.jp, Prevo, R.3, Steers, G.2, Roberts, H.2, Leek, R. D.2, Kimura, T.1, Kameoka, S.1, Nishikawa, T.4, Kobayashi, M.5, Jackson, D. G.3, Harris, A. L.6, Gatter, K. C.2, Pezzella, F.2
Publikováno v:
British Journal of Cancer. 11/14/2005, Vol. 93 Issue 10, p1168-1174. 7p. 1 Diagram, 6 Charts.