Zobrazeno 1 - 10 of 2 741 pro vyhledávání: '"Prevo R"'
1
Akademický článek
Antitumour effect of the mitochondrial complex III inhibitor Atovaquone in combination with anti-PD-L1 therapy in mouse cancer models.
Autor: Rodriguez-Berriguete G; Department of Oncology, University of Oxford, Oxford, UK. gonzalo.rodriguez@oncology.ox.ac.uk., Puliyadi R; Department of Oncology, University of Oxford, Oxford, UK., Machado N; Department of Oncology, University of Oxford, Oxford, UK., Barberis A; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Prevo R; Department of Oncology, University of Oxford, Oxford, UK., McLaughlin M; Institute of Cancer Research, London, UK., Buffa FM; Department of Oncology, University of Oxford, Oxford, UK.; Department of Computing Sciences, Bocconi University, Milan, Italy., Harrington KJ; Institute of Cancer Research, London, UK., Higgins GS; Department of Oncology, University of Oxford, Oxford, UK. geoffrey.higgins@oncology.ox.ac.uk.
Publikováno v: Cell death & disease [Cell Death Dis] 2024 Jan 11; Vol. 15 (1), pp. 32. Date of Electronic Publication: 2024 Jan 11.
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2
Akademický článek
Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models.
Autor: Rodriguez-Berriguete G; Department of Oncology, University of Oxford, Oxford, United Kingdom., Ranzani M; Artios Pharma, Babraham Research Campus, Cambridge, United Kingdom., Prevo R; Department of Oncology, University of Oxford, Oxford, United Kingdom., Puliyadi R; Department of Oncology, University of Oxford, Oxford, United Kingdom., Machado N; Department of Oncology, University of Oxford, Oxford, United Kingdom., Bolland HR; Department of Oncology, University of Oxford, Oxford, United Kingdom., Millar V; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Ebner D; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Boursier M; Artios Pharma, Babraham Research Campus, Cambridge, United Kingdom., Cerutti A; Artios Pharma, Babraham Research Campus, Cambridge, United Kingdom., Cicconi A; Artios Pharma, Babraham Research Campus, Cambridge, United Kingdom., Galbiati A; Artios Pharma, Babraham Research Campus, Cambridge, United Kingdom., Grande D; Artios Pharma, Babraham Research Campus, Cambridge, United Kingdom., Grinkevich V; Artios Pharma, Babraham Research Campus, Cambridge, United Kingdom., Majithiya JB; Artios Pharma, Babraham Research Campus, Cambridge, United Kingdom., Piscitello D; Artios Pharma, Babraham Research Campus, Cambridge, United Kingdom., Rajendra E; Artios Pharma, Babraham Research Campus, Cambridge, United Kingdom., Stockley ML; Artios Pharma, Babraham Research Campus, Cambridge, United Kingdom., Boulton SJ; Artios Pharma, Babraham Research Campus, Cambridge, United Kingdom.; The Francis Crick Institute, London, United Kingdom., Hammond EM; Department of Oncology, University of Oxford, Oxford, United Kingdom., Heald RA; Artios Pharma, Babraham Research Campus, Cambridge, United Kingdom., Smith GCM; Artios Pharma, Babraham Research Campus, Cambridge, United Kingdom., Robinson HMR; Artios Pharma, Babraham Research Campus, Cambridge, United Kingdom., Higgins GS; Department of Oncology, University of Oxford, Oxford, United Kingdom.
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2023 Apr 14; Vol. 29 (8), pp. 1631-1642.
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3
Targeting TOPK 1 sensitises tumour cells to radiation-induced damage by enhancing replication stress
Autor: Herbert, K, Puliyadi, R, Prevo, R, Rodriguez Berriguete, G, Ryan, A, Ramadan, K, Higgins, G
T-LAK-originated protein kinase (TOPK) overexpression is a feature of multiple cancers, yet is absent from most phenotypically normal tissues. As such, TOPK expression profiling and the development of TOPK-targeting pharmaceutical agents have raised
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::ceaaf893d3eb70d11714751e9b60c826
https://ora.ox.ac.uk/objects/uuid:56ca0e9a-15bc-460c-b2e3-cbe4e483395d
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4
Buparlisib with thoracic radiotherapy and its effect on tumour hypoxia: a phase I study in patients with advanced non-small cell lung carcinoma
Autor: McGowan, D, Skwarski, M, Bradley, K, Campo, L, Fenwick, J, Gleeson, F, Green, M, Horne, A, Maughan, T, McCole, M, Mohammed, S, Muschel, R, Ng, S, Panakis, N, Prevo, R, Strauss, V, Stuart, R, Tacconi, E, Vallis, K, McKenna, W, Macpherson, R, Higgins, G
Publikováno v: European journal of cancer (Oxford, England : 1990)
EUROPEAN JOURNAL OF CANCER
Background\udPre-clinically, phosphoinositide 3-kinase (PI3K) inhibition radiosensitises tumours by increasing intrinsic radiosensitivity and by reducing tumour hypoxia. We assessed whether buparlisib, a class 1 PI3K inhibitor, can be safely combined
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::16c33e885cf6d183ca26e4fa34718fe7
https://orca.cardiff.ac.uk/id/eprint/131982/1/PIIS0959804919302126.pdf
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5
Akademický článek
A quantitative analysis of lymphatic vessels in human breast cancer, based on LYVE-1 immunoreactivity.
Autor: Kato, T.1,2 t-kato@bd5.so-net.ne.jp, Prevo, R.3, Steers, G.2, Roberts, H.2, Leek, R. D.2, Kimura, T.1, Kameoka, S.1, Nishikawa, T.4, Kobayashi, M.5, Jackson, D. G.3, Harris, A. L.6, Gatter, K. C.2, Pezzella, F.2
Publikováno v: British Journal of Cancer. 11/14/2005, Vol. 93 Issue 10, p1168-1174. 7p. 1 Diagram, 6 Charts.
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7
Akademický článek
MO-0137 A basis for combining atovaquone-mediated hypoxia alleviation with immunotherapy plus radiotherapy
Autor: Rodriguez-Berriguete, G., Puliyadi, R., Prevo, R., Pugh, C.W., Higgins, G.S.
Publikováno v: In Radiotherapy and Oncology May 2022 170 Supplement 1:S113-S114
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8
Akademický článek
Automated 96-well format high throughput colony formation assay for siRNA library screen.
Autor: Hatch SB; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Prevo R; Department of Oncology, University of Oxford, Oxford, UK., Chan T; Department of Oncology, University of Oxford, Oxford, UK., Millar V; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Cornelissen B; Department of Oncology, University of Oxford, Oxford, UK., Higgins G; Department of Oncology, University of Oxford, Oxford, UK., Ebner D; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Publikováno v: STAR protocols [STAR Protoc] 2022 May 01; Vol. 3 (2), pp. 101355. Date of Electronic Publication: 2022 May 01 (Print Publication: 2022).
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9
T-LAK cell-originated protein kinase (TOPK): an emerging target for cancer-specific therapeutics
Autor: Herbert, K, Ashton, T, Prevo, R, Pirovano, G, Higgins, G
Publikováno v: Cell Death & Disease
Cell Death and Disease, Vol 9, Iss 11, Pp 1-10 (2018)
‘Targeted’ or ‘biological’ cancer treatments rely on differential gene expression between normal tissue and cancer, and genetic changes that render tumour cells especially sensitive to the agent being applied. Problems exist with the applicat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d517c7780fcfcf3b0acda301da9403f5
https://ora.ox.ac.uk/objects/uuid:586e4a8d-e902-4d11-941e-ee361b3e3d8f
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10
Nucleoporin 54 contributes to Homologous recombination repair and post-replicative DNA integrity
Autor: Rodriguez-Berriguete, G, Granata, G, Puliyadi, R, Tiwana, G, Prevo, R, Wilson, R, Yu, S, Buffa, F, Humphrey, T, McKenna, W, Higgins, G
Publikováno v: Nucleic Acids Research
The nuclear pore complex (NPC) machinery is emerging as an important determinant in the maintenance of genome integrity and sensitivity to DNA double-strand break (DSB)-inducing agents, such as ionising radiation (IR). In this study, using a high-thr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a6f6f974259439c5bee8e601b4e4bc95
http://ora.ox.ac.uk/objects/uuid:
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