Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Prethish Sreenivas"'
Autor:
Silvia Pomella, Matteo Cassandri, Lucrezia D’Archivio, Antonella Porrazzo, Cristina Cossetti, Doris Phelps, Clara Perrone, Michele Pezzella, Antonella Cardinale, Marco Wachtel, Sara Aloisi, David Milewski, Marta Colletti, Prethish Sreenivas, Zoë S. Walters, Giovanni Barillari, Angela Di Giannatale, Giuseppe Maria Milano, Cristiano De Stefanis, Rita Alaggio, Sonia Rodriguez-Rodriguez, Nadia Carlesso, Christopher R. Vakoc, Enrico Velardi, Beat W. Schafer, Ernesto Guccione, Susanne A. Gatz, Ajla Wasti, Marielle Yohe, Myron Ignatius, Concetta Quintarelli, Janet Shipley, Lucio Miele, Javed Khan, Peter J. Houghton, Francesco Marampon, Berkley E. Gryder, Biagio De Angelis, Franco Locatelli, Rossella Rota
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Rhabdomyosarcomas (RMS) are pediatric mesenchymal-derived malignancies encompassing PAX3/7-FOXO1 Fusion Positive (FP)-RMS, and Fusion Negative (FN)-RMS with frequent RAS pathway mutations. RMS express the master myogenic transcription factor
Externí odkaz:
https://doaj.org/article/b02d638fdabc4c31acb1630b1acf4c96
Autor:
Jiangfei Chen, Kunal Baxi, Amanda E Lipsitt, Nicole Rae Hensch, Long Wang, Prethish Sreenivas, Paulomi Modi, Xiang Ru Zhao, Antoine Baudin, Daniel G Robledo, Abhik Bandyopadhyay, Aaron Sugalski, Anil K Challa, Dias Kurmashev, Andrea R Gilbert, Gail E Tomlinson, Peter Houghton, Yidong Chen, Madeline N Hayes, Eleanor Y Chen, David S Libich, Myron S Ignatius
Publikováno v:
eLife, Vol 12 (2023)
In embryonal rhabdomyosarcoma (ERMS) and generally in sarcomas, the role of wild-type and loss- or gain-of-function TP53 mutations remains largely undefined. Eliminating mutant or restoring wild-type p53 is challenging; nevertheless, understanding p5
Externí odkaz:
https://doaj.org/article/869c09202a0d4108bb57d631b09af023
Autor:
Silvia Pomella, Prethish Sreenivas, Berkley E. Gryder, Long Wang, David Milewski, Matteo Cassandri, Kunal Baxi, Nicole R. Hensch, Elena Carcarino, Young Song, Hsien-Chao Chou, Marielle E. Yohe, Benjamin Z. Stanton, Bruno Amadio, Ignazio Caruana, Cristiano De Stefanis, Rita De Vito, Franco Locatelli, Yidong Chen, Eleanor Y. Chen, Peter Houghton, Javed Khan, Rossella Rota, Myron S. Ignatius
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Rhabdomyosarcomas are tumours blocked in myogenic differentiation, which despite the expression of master muscle regulatory factors, including MYOD, are unable to differentiate. Here, the authors show that SNAI2 is upregulated by MYOD through super e
Externí odkaz:
https://doaj.org/article/13792164b2674112a670f2c8b5793e7e
Autor:
Myron S. Ignatius, Madeline N. Hayes, Riadh Lobbardi, Eleanor Y. Chen, Karin M. McCarthy, Prethish Sreenivas, Zainab Motala, Adam D. Durbin, Aleksey Molodtsov, Sophia Reeder, Alexander Jin, Sivasish Sindiri, Brian C. Beleyea, Deepak Bhere, Matthew S. Alexander, Khalid Shah, Charles Keller, Corinne M. Linardic, Petur G. Nielsen, David Malkin, Javed Khan, David M. Langenau
Publikováno v:
Cell Reports, Vol 19, Iss 11, Pp 2304-2318 (2017)
Tumor-propagating cells (TPCs) share self-renewal properties with normal stem cells and drive continued tumor growth. However, mechanisms regulating TPC self-renewal are largely unknown, especially in embryonal rhabdomyosarcoma (ERMS)—a common pedi
Externí odkaz:
https://doaj.org/article/faebeb2fcd654f42ab17377a17a33471
Autor:
Sindhu Subramaniam, Prethish Sreenivas, Sirisha Cheedipudi, Vatrapu Rami Reddy, Lingadahalli Subrahmanya Shashidhara, Ravi Kumar Chilukoti, Madhavi Mylavarapu, Jyotsna Dhawan
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65097 (2014)
Most cells in adult mammals are non-dividing: differentiated cells exit the cell cycle permanently, but stem cells exist in a state of reversible arrest called quiescence. In damaged skeletal muscle, quiescent satellite stem cells re-enter the cell c
Externí odkaz:
https://doaj.org/article/7f6c73210c844d5092da52ec65f997be
Autor:
Myron S. Ignatius, Peter J. Houghton, Angelina V. Vaseva, Paulomi Modi, Xiang R. Zhao, Prethish Sreenivas, Long Wang, Kathryn Bondra, Nicole R. Hensch
Supplementary Materials, Methods, and References
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee339fed548c05476a1f71a5664e8e4
https://doi.org/10.1158/1535-7163.22523314
https://doi.org/10.1158/1535-7163.22523314
Autor:
Myron S. Ignatius, Peter J. Houghton, Angelina V. Vaseva, Paulomi Modi, Xiang R. Zhao, Prethish Sreenivas, Long Wang, Kathryn Bondra, Nicole R. Hensch
Supplementary Figures and Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3602236cfa7ff5228e66db62559c1470
https://doi.org/10.1158/1535-7163.22523317.v1
https://doi.org/10.1158/1535-7163.22523317.v1
Autor:
Myron S. Ignatius, Peter J. Houghton, Javed Khan, Rossella Rota, Eleanor Y. Chen, Siyuan Zheng, Benjamin Z. Stanton, Silvia Pomella, Berkley E. Gryder, Benjamin D. Sunkel, Angelina V. Vaseva, Kunal Baxi, Rodrigo Moreno Campos, Jiangfei Chen, Xiang R. Zhao, Prethish Sreenivas, Kathryn Bondra, Nicole R. Hensch, Long Wang
Materials and Methods used for experiments in Supplemental Figures and Supplemental References
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e197ff05af2e7311b611224ccc88a71
https://doi.org/10.1158/0008-5472.22428190.v1
https://doi.org/10.1158/0008-5472.22428190.v1
Autor:
Myron S. Ignatius, Peter J. Houghton, Javed Khan, Rossella Rota, Eleanor Y. Chen, Siyuan Zheng, Benjamin Z. Stanton, Silvia Pomella, Berkley E. Gryder, Benjamin D. Sunkel, Angelina V. Vaseva, Kunal Baxi, Rodrigo Moreno Campos, Jiangfei Chen, Xiang R. Zhao, Prethish Sreenivas, Kathryn Bondra, Nicole R. Hensch, Long Wang
Ionizing radiation (IR) and chemotherapy are mainstays of treatment for patients with rhabdomyosarcoma, yet the molecular mechanisms that underlie the success or failure of radiotherapy remain unclear. The transcriptional repressor SNAI2 was previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e81fbc5f146e0c76c15cead7bbbcf5d2
https://doi.org/10.1158/0008-5472.c.6512941.v1
https://doi.org/10.1158/0008-5472.c.6512941.v1
Autor:
Myron S. Ignatius, Peter J. Houghton, Javed Khan, Rossella Rota, Eleanor Y. Chen, Siyuan Zheng, Benjamin Z. Stanton, Silvia Pomella, Berkley E. Gryder, Benjamin D. Sunkel, Angelina V. Vaseva, Kunal Baxi, Rodrigo Moreno Campos, Jiangfei Chen, Xiang R. Zhao, Prethish Sreenivas, Kathryn Bondra, Nicole R. Hensch, Long Wang
Supplementary Figures S1-S9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258aa90145bdb5c23a9eaf62dacd01ea
https://doi.org/10.1158/0008-5472.22428193
https://doi.org/10.1158/0008-5472.22428193