The association between single-nucleotide polymorphisms within type 1 interferon pathway genes and human immunodeficiency virus type 1 viral load in antiretroviral-naïve participants

Autor: Sara Bohnstedt Mørup, Preston Leung, Cavan Reilly, Brad T. Sherman, Weizhong Chang, Maja Milojevic, Ana Milinkovic, Angelike Liappis, Line Borgwardt, Kathy Petoumenos, Roger Paredes, Shweta S. Mistry, Cameron R. MacPherson, Jens Lundgren, Marie Helleberg, Joanne Reekie, Daniel D. Murray, for the INSIGHT FIRST and START study groups

Publikováno v: AIDS Research and Therapy, Vol 21, Iss 1, Pp 1-14 (2024)

Abstract Background Human genetic contribution to HIV progression remains inadequately explained. The type 1 interferon (IFN) pathway is important for host control of HIV and variation in type 1 IFN genes may contribute to disease progression. This s

Externí odkaz: https://doaj.org/article/8aa261a5c95940b6ad7f4516bcd362c8

Identification of human progenitors of exhausted CD8+ T cells associated with elevated IFN-γ response in early phase of viral infection

Autor: Curtis Cai, Jerome Samir, Mehdi R. Pirozyan, Thiruni N. Adikari, Money Gupta, Preston Leung, Brendan Hughes, Willem Van der Byl, Simone Rizzetto, Auda Elthala, Elizabeth Keoshkerian, Jean-Louis Palgen, Timothy Peters, Thi H. O. Nguyen, Raymond Louie, Katherine Kedzierska, Silvana Gaudieri, Rowena A. Bull, Andrew R. Lloyd, Fabio Luciani

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

The early immune response following exposure to HCV is not fully explored. Here the authors use single cell analysis and immune profiling to relate the infection sequence and immune response to early HCV infection showing that exhausted phenotypes of

Externí odkaz: https://doaj.org/article/588f772ffcbf4737b2226e6c72bd6b81

Adaptation of Oxford Nanopore technology for hepatitis C whole genome sequencing and identification of within-host viral variants

Autor: Nasir Riaz, Preston Leung, Kirston Barton, Martin A. Smith, Shaun Carswell, Rowena Bull, Andrew R. Lloyd, Chaturaka Rodrigo

Publikováno v: BMC Genomics, Vol 22, Iss 1, Pp 1-12 (2021)

Abstract Background Hepatitis C (HCV) and many other RNA viruses exist as rapidly mutating quasi-species populations in a single infected host. High throughput characterization of full genome, within-host variants is still not possible despite advanc

Externí odkaz: https://doaj.org/article/27ac5a45c50a4b9891f2a9cec58eaa4c

Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring

Autor: Neil A Youngson, Virginie Lecomte, Christopher A Maloney, Preston Leung, Jia Liu, Luke B Hesson, Fabio Luciani, Lutz Krause, Margaret J Morris

Publikováno v: Asian Journal of Andrology, Vol 18, Iss 6, Pp 930-936 (2016)

There is now strong evidence that the paternal contribution to offspring phenotype at fertilisation is more than just DNA. However, the identity and mechanisms of this nongenetic inheritance are poorly understood. One of the more important questions

Externí odkaz: https://doaj.org/article/0ed6e12b3ceb408b94b78873d07da818

Association between ten-eleven methylcytosine dioxygenase 2 genetic variation and viral load in people with HIV

Autor: Daniel D. Murray, Birgit Grund, Cameron R. MacPherson, Christina Ekenberg, Adrian G. Zucco, Joanne Reekie, Lourdes Dominguez-Dominguez, Preston Leung, Dahlene Fusco, Julien Gras, Jan Gerstoft, Marie Helleberg, Álvaro H. Borges, Mark N. Polizzotto, Jens D. Lundgren

Publikováno v: Murray, D D, Grund, B, Macpherson, C R, Ekenberg, C, Zucco, A G, Reekie, J, Dominguez-Dominguez, L, Leung, P, Fusco, D, Gras, J, Gerstoft, J, Helleberg, M, Borges, Á H, Polizzotto, M N & Lundgren, J D 2023, ' Association between ten-eleven methylcytosine dioxygenase 2 genetic variation and viral load in people with HIV ', AIDS, vol. 37, no. 3, pp. 379-387 . https://doi.org/10.1097/QAD.0000000000003427

Introduction:Identifying genetic factors that influence HIV-pathogenesis is critical for understanding disease pathways. Previous studies have suggested a role for the human gene ten-eleven methylcytosine dioxygenase 2 (TET2) in modulating HIV-pathog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b5b50e2d72d6a0411ea9f4545e2dec
https://curis.ku.dk/portal/da/publications/association-between-teneleven-methylcytosine-dioxygenase-2-genetic-variation-and-viral-load-in-people-with-hiv(a9044e18-952b-4359-af38-2036ff34020a).html