Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Preston Ge"'
Autor:
Xiaobo Mao, Hao Gu, Donghoon Kim, Yasuyoshi Kimura, Ning Wang, Enquan Xu, Ramhari Kumbhar, Xiaotian Ming, Haibo Wang, Chan Chen, Shengnan Zhang, Chunyu Jia, Yuqing Liu, Hetao Bian, Senthilkumar S. Karuppagounder, Fatih Akkentli, Qi Chen, Longgang Jia, Heehong Hwang, Su Hyun Lee, Xiyu Ke, Michael Chang, Amanda Li, Jun Yang, Cyrus Rastegar, Manjari Sriparna, Preston Ge, Saurav Brahmachari, Sangjune Kim, Shu Zhang, Yasushi Shimoda, Martina Saar, Haiqing Liu, Sin Ho Kweon, Mingyao Ying, Creg J. Workman, Dario A. A. Vignali, Ulrike C. Muller, Cong Liu, Han Seok Ko, Valina L. Dawson, Ted M. Dawson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Pathologic α-synuclein (α-syn) spreads from cell-to-cell, in part, through binding to the lymphocyte-activation gene 3 (Lag3). Here we report that amyloid β precursor-like protein 1 (Aplp1) interacts with Lag3 that facilitates the binding
Externí odkaz:
https://doaj.org/article/a51c0a5470e944f6b5b546f3fa48e34f
Autor:
Xiaobo Mao, Hao Gu, Donghoon Kim, Yasuyoshi Kimura, Ning Wang, Enquan Xu, Ramhari Kumbhar, Xiaotian Ming, Haibo Wang, Chan Chen, Shengnan Zhang, Chunyu Jia, Yuqing Liu, Hetao Bian, Senthilkumar S. Karuppagounder, Fatih Akkentli, Qi Chen, Longgang Jia, Heehong Hwang, Su Hyun Lee, Xiyu Ke, Michael Chang, Amanda Li, Jun Yang, Cyrus Rastegar, Manjari Sriparna, Preston Ge, Saurav Brahmachari, Sangjune Kim, Shu Zhang, Yasushi Shimoda, Martina Saar, Haiqing Liu, Sin Ho Kweon, Mingyao Ying, Creg J. Workman, Dario A. A. Vignali, Ulrike C. Muller, Cong Liu, Han Seok Ko, Valina L. Dawson, Ted M. Dawson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/59a521d03e984273bb3d708b36d570e9
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-18 (2020)
Abstract That certain cell types in the central nervous system are more likely to undergo neurodegeneration in Parkinson’s disease is a widely appreciated but poorly understood phenomenon. Many vulnerable subpopulations, including dopamine neurons
Externí odkaz:
https://doaj.org/article/4afa86c1f00847c8823649cc2bf19a3e
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-18 (2020)
Molecular Neurodegeneration
Molecular Neurodegeneration
That certain cell types in the central nervous system are more likely to undergo neurodegeneration in Parkinson’s disease is a widely appreciated but poorly understood phenomenon. Many vulnerable subpopulations, including dopamine neurons in the su
Autor:
Xiaobo Mao, Hao Gu, Donghoon Kim, Yasuyoshi Kimura, Ning Wang, Enquan Xu, Haibo Wang, Chan Chen, Shengnan Zhang, Chunyu Jia, Yuqing Liu, Hetao Bian, Senthilkumar S. Karuppagounder, Longgang Jia, Xiyu Ke, Michael Chang, Amanda Li, Jun Yang, Cyrus Rastegar, Manjari Sriparna, Preston Ge, Saurav Brahmachari, Sangjune Kim, Shu Zhang, Yasushi Shimoda, Martina Saar, Creg J. Workman, Dario A. A. Vignali, Ulrike C. Muller, Cong Liu, Han Seok Ko, Valina L. Dawson, Ted M. Dawson
Pathologic α-synuclein (α-syn) spreads from cell-to-cell, in part, through binding to the lymphocyte-activation gene 3 (Lag3). Here we report that amyloid β precursor-like protein 1 (Aplp1) forms a complex with Lag3 that facilitates the binding, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb7dceffac093036ea28598e9e898e92
https://doi.org/10.1101/2021.05.01.442157
https://doi.org/10.1101/2021.05.01.442157
Autor:
Rosa Shi, Sangjune Kim, Manoj Kumar, Preston Ge, Xiaobo Mao, Dong-Hoon Kim, Lino Tessarollo, Seung Pil Yun, Han Seok Ko, Saurav Brahmachari, Saebom Lee, Changqing Yuan, Tae In Kam, Esther J. Kim, Yunjong Lee, Haisong Jiang, Deborah A. Swing, Ted M. Dawson, Alex Liu, Stephan Quintin, Senthilkumar S. Karuppagounder, Valina L. Dawson
Publikováno v:
Brain
α-Synuclein misfolding and aggregation plays a major role in the pathogenesis of Parkinson’s disease. Although loss of function mutations in the ubiquitin ligase, parkin, cause autosomal recessive Parkinson’s disease, there is evidence that park
Publikováno v:
J Cell Biol
Parkinson’s disease (PD) is a progressive neurodegenerative disorder resulting from the death of dopamine neurons in the substantia nigra pars compacta. Our understanding of PD biology has been enriched by the identification of genes involved in it
Autor:
Valina L. Dawson, Saurav Brahmachari, Senthilkumar S. Karuppagounder, Han Seok Ko, Saebom Lee, Preston Ge, Ted M. Dawson
Publikováno v:
Journal of Parkinson's Disease
Although the etiology of Parkinson’s disease (PD) is poorly understood, oxidative stress has long been implicated in the pathogenesis of the disease. However, multifaceted and divergent signaling cascades downstream of oxidative stress have posed c
Autor:
Donghyun Kim, Yulan Xiong, Shaida A. Andrabi, Ted M. Dawson, Saurav Brahmachari, Aanishaa Jhaldiyal, Emily Nordquist, Manoj Kumar, Ian Martin, Yunjong Lee, Valina L. Dawson, Maeve C. Lawless, Senthilkumar S. Karuppagounder, Preston Ge
Publikováno v:
Journal of Chemical Neuroanatomy. 76:90-97
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common causes of late onset autosomal dominant form of Parkinson disease (PD). Gain of kinase activity due to the substitution of Gly 2019 to Ser (G2019S) is the most common mutation in t
Autor:
Yu Liang, Saurav Brahmachari, Valina L. Dawson, Sung Ung Kang, Creg J. Workman, Seung Pil Yun, Yulan Xiong, Ho Chul Kang, Xiling Yin, George Essien Umanah, Ted M. Dawson, Rong Chen, Senthilkumar S. Karuppagounder, Chen Qi, Nikhil Panicker, Sharon Lam, Jinchong Xu, Michael Tianhao Ou, Shaida A. Andrabi, Dario A. A. Vignali, Joel Tyson, Joo Ho Shin, Jianmin Zhang, Dong-Hoon Kim, Hyejin Park, Rafaella Araújo Gonçalves, James A. Keiler, Xiaobo Mao, Han Seok Ko, Shu Zhang, Preston Ge, Tae In Kam
Publikováno v:
Science (New York, N.Y.). 353(6307)
INTRODUCTION Parkinson’s disease (PD) is the second most common neurodegenerative disorder and leads to slowness of movement, tremor, rigidity, and, in the later stages of PD, cognitive impairment. Pathologically, PD is characterized by the accumul