Zobrazeno 1 - 10
of 1 857
pro vyhledávání: '"Preston E"'
Publikováno v:
Biomolecules, Vol 14, Iss 11, p 1378 (2024)
VX-770 is a small-molecule CFTR potentiator that is highly efficacious in individuals with cystic fibrosis caused by mutations in CFTR that result in a defect in channel gating. While studies have reported on the mechanism of action of VX-770, there
Externí odkaz:
https://doaj.org/article/610fc416885b4131b15c491660bb09d8
Autor:
Todd M. Mowery, Preston E. Garraghty
Publikováno v:
Frontiers in Systems Neuroscience, Vol 16 (2023)
Although neural plasticity is now widely studied, there was a time when the idea of adult plasticity was antithetical to the mainstream. The essential stumbling block arose from the seminal experiments of Hubel and Wiesel who presented convincing evi
Externí odkaz:
https://doaj.org/article/73bf0f997cca46a78b9d6c3dfafa1353
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Quantitation of CFTR function in vitro is commonly performed by acutely stimulating then inhibiting ion transport through CFTR and measuring the resulting changes in transepithelial voltage (Vte) and current (ISC). While this technique is su
Externí odkaz:
https://doaj.org/article/8dd03599bdb7470298956a04c6a75ed2
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-4 (2021)
Externí odkaz:
https://doaj.org/article/340dd07fd2344aaf8ea3bac3a33a3f78
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), which lead to early death due to progressive lung disease. The development of small-molecule modulators that directly interact wit
Externí odkaz:
https://doaj.org/article/ada0900b04f2474491bb981f326adf27
Autor:
Katherine G. Holder, Bernardo Galvan, Andrew S. Knight, Freedom Ha, Reagan Collins, Preston E. Weaver, Luis Brandi, Werner T. de Riese
Publikováno v:
Investigative and Clinical Urology, Vol 62, Iss 4, Pp 423-429 (2021)
Purpose: The negative correlation between BPH-size and incidence of prostate cancer (PCa) is well-documented in the literature, however the exact mechanism is not well-understood. The present study uses histo-anatomical imaging to study prostate volu
Externí odkaz:
https://doaj.org/article/66fb8ed3289f4bdb83b53657595049af
Autor:
Maya E. Kotas, Camille M. Moore, Jose G. Gurrola II, Steven D. Pletcher, Andrew N. Goldberg, Raquel Alvarez, Sheyla Yamato, Preston E. Bratcher, Ciaran A. Shaughnessy, Pamela L. Zeitlin, Irene H. Zhang, Yingchun Li, Michael T. Montgomery, Keehoon Lee, Emily K. Cope, Richard M. Locksley, Max A. Seibold, Erin D. Gordon
Publikováno v:
JCI Insight, Vol 7, Iss 13 (2022)
Chronic type 2 (T2) inflammatory diseases of the respiratory tract are characterized by mucus overproduction and disordered mucociliary function, which are largely attributed to the effects of IL-13 on common epithelial cell types (mucus secretory an
Externí odkaz:
https://doaj.org/article/6f5341174d7842269c992904cbd03de8
Autor:
Katherine C. Goldfarbmuren, Nathan D. Jackson, Satria P. Sajuthi, Nathan Dyjack, Katie S. Li, Cydney L. Rios, Elizabeth G. Plender, Michael T. Montgomery, Jamie L. Everman, Preston E. Bratcher, Eszter K. Vladar, Max A. Seibold
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Chronic lung diseases are characterized by molecular and cellular composition changes. Here the authors use single-cell RNA sequencing to map cell type-specific changes in human tracheal epithelium related to smoking, and to provide evidence for a tu
Externí odkaz:
https://doaj.org/article/9bcec16a7aeb4036b62487f931077a83
Publikováno v:
BMJ Open Respiratory Research, Vol 8, Iss 1 (2021)
Introduction The incubation of airway epithelia cells at low temperatures is a common in vitro experimental approach used in the field of cystic fibrosis (CF) research to thermo-stabilise F508del-CFTR and increase its functional expression. Given tha
Externí odkaz:
https://doaj.org/article/a8a2166685bd4b53a0d876b3a9dc4cf9
Publikováno v:
Physiological Reports, Vol 8, Iss 19, Pp n/a-n/a (2020)
Abstract Introduction One method for assessing the in vitro response to CFTR‐modulating compounds is by analysis of epithelial monolayers in an Ussing chamber, where the apical and basolateral surfaces are isolated and the potential difference, sho
Externí odkaz:
https://doaj.org/article/cbecdc03fbdc48c6b66e43318d5afcf5