Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease.

Autor: Dalmasso MC; Laboratory of Amyloidosis and Neurodegeneration, Fundación Instituto Leloir-IIBBA-CONICET, Ciudad Autónoma de Buenos Aires (C.A.B.A.), Buenos Aires, Argentina., Brusco LI; Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A, Buenos Aires, Argentina.; Departamento Ciencias Fisiológicas UAII, Facultad de Medicina, UBA, C.A.B.A, Buenos Aires, Argentina.; Hospital Interzonal General de Agudos Eva Perón, San Martín, Buenos Aires, Argentina., Olivar N; Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A, Buenos Aires, Argentina.; Departamento Ciencias Fisiológicas UAII, Facultad de Medicina, UBA, C.A.B.A, Buenos Aires, Argentina., Muchnik C; Laboratorio de Bioquímica Molecular, Facultad de Medicina, Instituto de Investigaciones Médicas A. Lanari, UBA, C.A.B.A, Buenos Aires, Argentina., Hanses C; Department of Psychiatry and Psychotherapy, University of Bonn, 53127, Bonn, Germany., Milz E; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, 50937, Cologne, Germany., Becker J; Department of Psychiatry and Psychotherapy, University of Bonn, 53127, Bonn, Germany., Heilmann-Heimbach S; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital, 53127, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, 53127, Bonn, Germany., Hoffmann P; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital, 53127, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, 53127, Bonn, Germany.; Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, CH-4058, Basel, Switzerland., Prestia FA; Laboratory of Amyloidosis and Neurodegeneration, Fundación Instituto Leloir-IIBBA-CONICET, Ciudad Autónoma de Buenos Aires (C.A.B.A.), Buenos Aires, Argentina., Galeano P; Laboratory of Amyloidosis and Neurodegeneration, Fundación Instituto Leloir-IIBBA-CONICET, Ciudad Autónoma de Buenos Aires (C.A.B.A.), Buenos Aires, Argentina., Avalos MSS; Ministerio de Salud de la Provincia de Jujuy, Programa del Adulto Mayor, San Salvador de Jujuy, Jujuy, Argentina., Martinez LE; Hospital Interzonal General de Agudos Eva Perón, San Martín, Buenos Aires, Argentina., Carulla ME; Hospital Interzonal General de Agudos Eva Perón, San Martín, Buenos Aires, Argentina., Azurmendi PJ; Laboratorio de Bioquímica Molecular, Facultad de Medicina, Instituto de Investigaciones Médicas A. Lanari, UBA, C.A.B.A, Buenos Aires, Argentina., Liberczuk C; Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A, Buenos Aires, Argentina., Fezza C; Laboratorio de Bioquímica Molecular, Facultad de Medicina, Instituto de Investigaciones Médicas A. Lanari, UBA, C.A.B.A, Buenos Aires, Argentina., Sampaño M; Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A, Buenos Aires, Argentina., Fierens M; Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A, Buenos Aires, Argentina., Jemar G; Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A, Buenos Aires, Argentina., Solis P; Neurosciences and Complex Systems Unit (EnyS), CONICET, Hospital El Cruce 'Dr. Néstor Kirchner', Univ Arturo Jauretche, F. Varela, Buenos Aires, Argentina., Medel N; Neurosciences and Complex Systems Unit (EnyS), CONICET, Hospital El Cruce 'Dr. Néstor Kirchner', Univ Arturo Jauretche, F. Varela, Buenos Aires, Argentina., Lisso J; Neurosciences and Complex Systems Unit (EnyS), CONICET, Hospital El Cruce 'Dr. Néstor Kirchner', Univ Arturo Jauretche, F. Varela, Buenos Aires, Argentina., Sevillano Z; Neurosciences and Complex Systems Unit (EnyS), CONICET, Hospital El Cruce 'Dr. Néstor Kirchner', Univ Arturo Jauretche, F. Varela, Buenos Aires, Argentina., Bosco P; Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Associazione Oasi Maria Santissima Srl, Troina, Italy., Bossù P; Department of Clinical and Behavioural Neurology, Experimental Neuropsychobiology Laboratory, Rome, Italy., Spalletta G; Department of Clinical and Behavioural Neurology, Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Galimberti D; Neurodegenerative Diseases Center, University of Milan, Centro Dino Ferrari, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy., Mancuso M; Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy., Nacmias B; NEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy., Sorbi S; NEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy.; IRCCS 'Don Carlo Gnocchi', Florence, Italy., Mecocci P; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., Pilotto A; Geriatric Unit and Gerontology-Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Caffarra P; Section of Neuroscience, DIMEC, University of Parma, Parma, Italy.; Alzheimer Center, FERB, Gazzaniga, Bergamo, Italy., Panza F; Neurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy., Bullido M; Instituto de Investigación Sanitaria Hospital la Paz (IdiPAZ), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain., Clarimon J; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain., Sánchez-Juan P; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Coto E; Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain., Sanchez-Garcia F; Immunology Service, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain., Graff C; Genetics Unit, Theme Aging, Karolinska University Hospital, Solna, Sweden.; Division of Neurogeriatrics, Department NVS, Karolinska Institutet, Bioclincum J10:20, Solna, Sweden., Ingelsson M; Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden., Bellenguez C; INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, F-59000, Lille, France.; Institut Pasteur de Lille, F-59000, Lille, France.; University Lille, U1167-Excellence Laboratory LabEx DISTALZ, F-59000, Lille, France., Castaño EM; Laboratory of Amyloidosis and Neurodegeneration, Fundación Instituto Leloir-IIBBA-CONICET, Ciudad Autónoma de Buenos Aires (C.A.B.A.), Buenos Aires, Argentina., Kairiyama C; Hospital Interzonal General de Agudos Eva Perón, San Martín, Buenos Aires, Argentina., Politis DG; Hospital Interzonal General de Agudos Eva Perón, San Martín, Buenos Aires, Argentina., Kochen S; Neurosciences and Complex Systems Unit (EnyS), CONICET, Hospital El Cruce 'Dr. Néstor Kirchner', Univ Arturo Jauretche, F. Varela, Buenos Aires, Argentina., Scaro H; Ministerio de Salud de la Provincia de Jujuy, Programa del Adulto Mayor, San Salvador de Jujuy, Jujuy, Argentina., Maier W; German Center for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany.; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, 53127, Bonn, Germany., Jessen F; German Center for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Cologne, 50937, Cologne, Germany., Mangone CA; Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A, Buenos Aires, Argentina., Lambert JC; INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, F-59000, Lille, France.; Institut Pasteur de Lille, F-59000, Lille, France.; University Lille, U1167-Excellence Laboratory LabEx DISTALZ, F-59000, Lille, France., Morelli L; Laboratory of Amyloidosis and Neurodegeneration, Fundación Instituto Leloir-IIBBA-CONICET, Ciudad Autónoma de Buenos Aires (C.A.B.A.), Buenos Aires, Argentina. lmorelli@leloir.org.ar., Ramirez A; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, 50937, Cologne, Germany. alfredo.ramirez@uk-koeln.de.; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, 53127, Bonn, Germany. alfredo.ramirez@uk-koeln.de.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2019 Jan 31; Vol. 9 (1), pp. 55. Date of Electronic Publication: 2019 Jan 31.