Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Presenilin1"'
Autor:
Xiaotong Wang, Rui Zhou, Xiaqin Sun, Jun Li, Jinxin Wang, Weihua Yue, Lifang Wang, Hesheng Liu, Yigong Shi, Dai Zhang
Publikováno v:
Advanced Science, Vol 10, Iss 32, Pp n/a-n/a (2023)
Abstract A hallmark of Alzheimer's disease (AD) is the senile plaque, which contains β‐amyloid peptides (Aβ). Ganglioside GM1 is the most common brain ganglioside. However, the mechanism of GM1 in modulating Aβ processing is rarely known. Aβ le
Externí odkaz:
https://doaj.org/article/93404aa7e3f34b29b562184fa4160ed6
Autor:
Wei Yang, Yan Xiang, Mao-Jun Liao, Peng-Fei Wu, Lin Yang, Guo-Hao Huang, Bao-Zhong Shi, Liang Yi, Sheng-Qing Lv
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-16 (2021)
Abstract Background Alzheimer’s disease (AD) and glioblastoma are the most common and devastating diseases in the neurology and neurosurgery departments, respectively. Our previous research reports that the AD-related protein Presenilin1 represses
Externí odkaz:
https://doaj.org/article/a11393aa34b849108ff50c609a5f3e80
Autor:
Noemi Monti, Rosaria A. Cavallaro, Andrea Stoccoro, Vincenzina Nicolia, Sigfrido Scarpa, Gabor G. Kovacs, Maria Teresa Fiorenza, Marco Lucarelli, Eleonora Aronica, Isidre Ferrer, Fabio Coppedè, Aron M. Troen, Andrea Fuso
Publikováno v:
Epigenetics, Vol 15, Iss 8, Pp 781-799 (2020)
The Presenilin1 (PSEN1) gene encodes the catalytic peptide of the γ-secretase complex, a key enzyme that cleaves the amyloid-β protein precursor (AβPP), to generate the amyloid-β (Aβ) peptides, involved in Alzheimer’s Disease (AD). Other subst
Externí odkaz:
https://doaj.org/article/c0fb2fc80ff8444b929a6cd06863b2c1
Presenilin1 exerts antiproliferative effects by repressing the Wnt/β-catenin pathway in glioblastoma
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-13 (2020)
Abstract Background Glioblastoma and Alzheimer’s disease (AD) are the most common and devastating diseases in the central nervous system. The dysfunction of Presenilin1 is the main reason for AD pathogenesis. However, the molecular function of Pres
Externí odkaz:
https://doaj.org/article/0b2e9f5fc1d34ccbb31ce77d08e12872
Autor:
Joshua T. Fox‐Fuller, Heirangi Torrico‐Teave, Federico d'Oleire Uquillas, Kewei Chen, Yi Su, Yinghua Chen, Michael Brickhouse, Justin S. Sanchez, Cinthya Aguero, Heidi I.L. Jacobs, Olivia Hampton, Edmarie Guzmán‐Vélez, Clara Vila‐Castelar, Daniel C. Aguirre‐Acevedo, Ana Baena, Arabiye Artola, Jairo Martinez, Celina F. Pluim, Sergio Alvarez, Martin Ochoa‐Escudero, Eric M. Reiman, Reisa A. Sperling, Francisco Lopera, Keith A. Johnson, Bradford C. Dickerson, Yakeel T. Quiroz
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)
Abstract Introduction Cortical thinning is a marker of neurodegeneration in Alzheimer's disease (AD). We investigated the age‐related trajectory of cortical thickness across the lifespan (9‐59 years) in a Colombian kindred with autosomal dominant
Externí odkaz:
https://doaj.org/article/7a9a5af90bbf4517bba4147eb850487d
Autor:
Abril Angélica Escamilla-Ayala, Ragna Sannerud, Magali Mondin, Karin Poersch, Wendy Vermeire, Laura Paparelli, Caroline Berlage, Marcelle Koenig, Lucia Chavez-Gutierrez, Maximilian H Ulbrich, Sebastian Munck, Hideaki Mizuno, Wim Annaert
Publikováno v:
eLife, Vol 9 (2020)
γ-Secretase is a multi-subunit enzyme whose aberrant activity is associated with Alzheimer’s disease and cancer. While its structure is atomically resolved, γ-secretase localization in the membrane in situ relies mostly on biochemical data. Here,
Externí odkaz:
https://doaj.org/article/a670ba027c4a475a924b0ed9c1d6e874
Publikováno v:
Brain Sciences, Vol 11, Iss 10, p 1328 (2021)
Presenilin-1 (PSEN1) is one of the causative genes for early onset Alzheimer’s disease (EOAD). Recently, emerging studies have reported several novel PSEN1 mutations among Asians. In this study, a PSEN1 Val96Phe mutation was discovered in two sibli
Externí odkaz:
https://doaj.org/article/f4ad092fb84244a5b3704b0db2359049
Akademický článek
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Autor:
Andrew B. Caldwell, Qing Liu, Can Zhang, Gary P. Schroth, Douglas R. Galasko, Kevin D. Rynearson, Rudolph E. Tanzi, Shauna H. Yuan, Steven L. Wagner, Shankar Subramaniam
Publikováno v:
Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 18, iss 11
While amyloid-β (Aβ) plaques are considered a hallmark of Alzheimer's disease, clinical trials focused on targeting gamma secretase, an enzyme involved in aberrant Aβ peptide production, have not led to amelioration of AD symptoms or synaptic dysr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe12e3edf2dda83a590761d8e165637
https://doi.org/10.1002/alz.12553
https://doi.org/10.1002/alz.12553
Autor:
Vorapun Senanarong, Seong Soo A. An, Vo Van Giau, Chanin Limwongse, Eva Bagyinszky, SangYun Kim
Publikováno v:
Diagnostics, Vol 10, Iss 3, p 135 (2020)
A pathogenic mutation in PSEN1 p.Glu184Gly was discovered in a Thai family with early onset Alzheimer’s disease (EOAD) as the first case in Asia. Proband patient presented memory impairment and anxiety at the age of 41 years. Family history was pos
Externí odkaz:
https://doaj.org/article/5cb8f1f822394e8b97c8459a168dd11b