Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Prescott T. Leach"'
Autor:
Lynn A. Hyde, Qi Zhang, Robert A. Del Vecchio, Prescott T. Leach, Mary E. Cohen-Williams, Lei Chen, Gwendolyn T. Wong, Nansie A. McHugh, Joseph Chen, Guy A. Higgins, Theodros Asberom, Wei Li, Dmitri Pissarnitski, Diane Levitan, Amin A. Nomeir, John W. Clader, Lili Zhang, Eric M. Parker
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2013 (2013)
Substantial evidence implicates -amyloid (A) peptides in the etiology of Alzheimer’s disease (AD). A is produced by the proteolytic cleavage of the amyloid precursor protein by - and -secretase suggesting that -secretase inhibition may provide ther
Externí odkaz:
https://doaj.org/article/992cb89d5ff04869837af4acc77fb5af
Autor:
Mohammad Amani, Julie C. Lauterborn, A. E. Friedman, Prescott T. Leach, Christine M. Gall, Gary Lynch, Jacqueline N. Crawley, Aliza A. Le, Maria N. Schultz
Publikováno v:
Translational Psychiatry, Vol 9, Iss 1, Pp 1-16 (2019)
Translational Psychiatry
Translational Psychiatry
Benefits of distributed learning strategies have been extensively described in the human literature, but minimally investigated in intellectual disability syndromes. We tested the hypothesis that training trials spaced apart in time could improve lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995aa23574a02923adadf44902099677
https://doi.org/10.1038/s41398-019-0495-5
https://doi.org/10.1038/s41398-019-0495-5
Publikováno v:
Neuroscience Letters. 627:61-64
Acute nicotine enhances hippocampus-dependent learning. Identifying how acute nicotine improves learning will aid in understanding how nicotine facilitates the development of maladaptive memories that contribute to drug-seeking behaviors, help develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d769344e14de9d1a627a0ccd3b16d72
https://doi.org/10.1016/j.neulet.2016.05.048
https://doi.org/10.1016/j.neulet.2016.05.048
Publikováno v:
Genes, Brain and Behavior. 15:7-26
More than a hundred de novo single gene mutations and copy-number variants have been implicated in autism, each occurring in a small subset of cases. Mutant mouse models with syntenic mutations offer research tools to gain an understanding of the rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9f9179f4d5503c3d205aa2ee0409763
https://doi.org/10.1111/gbb.12256
https://doi.org/10.1111/gbb.12256
Publikováno v:
Neurobiology of Learning and Memory. 118:162-166
Increased training often results in stronger memories but the neural changes responsible for these stronger memories are poorly understood. It is proposed here that higher levels of training that result in stronger memories recruit additional cell si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da5d3fc00618434251582e48cd604ae
https://doi.org/10.1016/j.nlm.2014.12.008
https://doi.org/10.1016/j.nlm.2014.12.008
Publikováno v:
Neuropharmacology
Cigarette smoking is common despite adverse health effects. Nicotine's effects on learning may contribute to addiction by enhancing drug-context associations. Effects of nicotine on learning could be direct or could occur by altering systems that mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198438a75927f33f23362a0da994692e
http://europepmc.org/articles/PMC4387063
http://europepmc.org/articles/PMC4387063
Publikováno v:
Intractable & Rare Diseases Research. 3:118-133
Fragile X Syndrome (FXS) is a commonly inherited form of intellectual disability and one of the leading genetic causes for autism spectrum disorder. Clinical symptoms of FXS can include impaired cognition, anxiety, hyperactivity, social phobia, and r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b890f1f683ca659c734e80a8e3f39abd
https://doi.org/10.5582/irdr.2014.01024
https://doi.org/10.5582/irdr.2014.01024
Autor:
Tatiana M. Kazdoba, Prescott T. Leach, Marjorie Solomon, Jacqueline N. Crawley, Jill L. Silverman, Mu Yang
Publikováno v:
Translational Neuropsychopharmacology ISBN: 9783319339115
Animal models provide preclinical tools to investigate the causal role of genetic mutations and environmental factors in the etiology of autism spectrum disorder (ASD). Knockout and humanized knock-in mice, and more recently knockout rats, have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85da1af7bfcd4f0761290f5c1de96ac3
https://europepmc.org/articles/PMC5116923/
https://europepmc.org/articles/PMC5116923/
Autor:
Ted Abel, Dan A. Liebermann, Thomas J. Gould, Shane G. Poplawski, Prescott T. Leach, Barbara Hoffman, Justin W. Kenney
Publikováno v:
Learning & Memory. 19:319-324
Growth arrest and DNA damage-inducible β (Gadd45b) has been shown to be involved in DNA demethylation and may be important for cognitive processes. Gadd45b is abnormally expressed in subjects with autism and psychosis, two disorders associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee930af98684d9f8aaf1a45ae7a4eed4
https://doi.org/10.1101/lm.024984.111
https://doi.org/10.1101/lm.024984.111
Autor:
Sherry X. Lu, Carina J. Bleickardt, Donald H. Guthrie, Robert A. Hodgson, Geoffrey B. Varty, Eric M. Parker, Prescott T. Leach, Lynn A. Hyde, Mary Cohen-Williams, Tatiana M. Kazdoba
Publikováno v:
Pharmacology Biochemistry and Behavior. 98:181-187
Metabotropic glutamate receptor 1 (mGluR1) antagonists interfere with learning and memory; however, their role in motor function is not well elucidated despite their abundance in brain areas implicated in the control of movement. Here, the effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860e909bcee4856131d6cee8f1b39eed
https://doi.org/10.1016/j.pbb.2010.11.018
https://doi.org/10.1016/j.pbb.2010.11.018