Výsledky vyhledávání - "Prerna Malaney"

Akademický článek

The Eµ-hnRNP K Murine Model of Lymphoma: Novel Insights into the Role of hnRNP K in B-Cell Malignancies

Autor: Prerna Malaney, María Velasco-Estevez, Pedro Aguilar-Garrido, Marisa J. L. Aitken, Lauren E. Chan, Xiaorui Zhang, Sean M. Post, Miguel Gallardo

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

B-cell lymphomas are one of the most biologically and molecularly heterogeneous group of malignancies. The inherent complexity of this cancer subtype necessitates the development of appropriate animal model systems to characterize the disease with th

Externí odkaz: https://doaj.org/article/e1ec8fbf3f81483b8c448576d353cc89

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Creating accessibility in academic negotiations

Autor: Jennifer H. Kong, Claudia G. Vasquez, Sweta Agrawal, Prerna Malaney, Maria M. Mikedis, Andrea B. Moffitt, Lexy von Diezmann, Christina M. Termini

Publikováno v: Trends in Biochemical Sciences. 48:203-210

The process of evaluating and negotiating a tenure-track job offer is unstructured and highly variable, making it susceptible to bias and inequitable outcomes. We outline common aspects of and recommendations for negotiating an academic job offer in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaae8441370a0d524593336ee5215f12
https://doi.org/10.1016/j.tibs.2022.10.004

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The nucleolar aberrancies that drive ribosome impairment induced by RNA binding proteins are hallmarks of aging

The nucleolus is a dynamic structure where ribosome subunits are produced. Indeed, nucleoli respond to any change in cellular homeostasis by altering the rate of ribosome biogenesis, thus working as a stress sensor. Therefore, an imbalance in ribosom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5197402493775104cec9ed910821d935
https://doi.org/10.1101/2023.03.07.531270

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Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling

Autor: Dhwani N. Rupani, Fredrik I. Thege, Vidhi Chandra, Hajar Rajaei, Robert W. Cowan, Sonja M. Wörmann, Olivereen Le Roux, Prerna Malaney, Sara L. Manning, Jack Hashem, Jennifer Bailey-Lundberg, Andrew D. Rhim, Florencia McAllister

Publikováno v: Development. 150

Adenosine deaminase acting on RNA 1 (ADAR1) is an RNA-binding protein that deaminates adenosine (A) to inosine (I). A-to-I editing alters post-transcriptional RNA processing, making ADAR1 a crucial regulator of gene expression. Consequently, Adar1 ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67188c62b4f8fc634e017d67fd0cb299
https://doi.org/10.1242/dev.201097

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AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3-ITD acute myeloid leukemia

Autor: Joseph D. Khoury, Prerna Malaney, Courtney D. DiNardo, Bing Z. Carter, Lauren B Ostermann, Michael Andreeff, Ryohei Kozaki, Xiaorui Zhang, Marina Konopleva, Sean M. Post, Marisa J.L. Aitken, Peter P. Ruvolo, Huaxian Ma, Vivian Ruvolo, Tomoko Yasuhiro, Po Yee Mak, Lauren E. Chan

Publikováno v: Haematologica. 107:1311-1322

FMS-like Tyrosine Kinase 3 (FLT3) mutation is associated with poor survival in acute myeloid leukemia (AML). The specific Anexelekto/MER Tyrosine Kinase (AXL) inhibitor, ONO-7475, kills FLT3-mutant AML cells with targets including Extracellular- sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97f3a61a1f781eb77a3343aa842372ef
https://doi.org/10.3324/haematol.2021.278369

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Heterogeneous nuclear ribonucleoprotein K is overexpressed in acute myeloid leukemia and causes myeloproliferation in mice via altered Runx1 splicing

Autor: Marisa J L Aitken, Prerna Malaney, Xiaorui Zhang, Shelley M Herbrich, Lauren Chan, Oscar Benitez, Ashley G Rodriguez, Huaxian Ma, Rodrigo Jacamo, Ruizhi Duan, Todd M Link, Steven M Kornblau, Rashmi Kanagal-Shamanna, Carlos E Bueso-Ramos, Sean M Post

Publikováno v: NAR Cancer. 4

Acute myeloid leukemia (AML) is driven by numerous molecular events that contribute to disease progression. Herein, we identify hnRNP K overexpression as a recurrent abnormality in AML that negatively correlates with patient survival. Overexpression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ead813de49f6bc0d358b002c018f8e4
https://doi.org/10.1093/narcan/zcac039

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Assessing the role of intrinsic disorder in RNA-binding protein function: hnRNP K as a case study

Autor: Prerna Malaney, Oscar Benitez, Xiaorui Zhang, Sean M. Post

Publikováno v: Methods (San Diego, Calif.). 208

RNA-binding proteins (RBPs) typically bind to RNA in a sequence-specific manner, resulting in post-transcriptional gene regulation. While the various classes of RNA-binding domains are largely structured, flexible linkers are frequently observed betw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30fed91040ce09f667c3354f87326f4
https://pubmed.ncbi.nlm.nih.gov/36334888

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