Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Prerana Purohit"'
Autor:
Lynnette A. Averill, Lihong Jiang, Prerana Purohit, Anastasia Coppoli, Christopher L. Averill, Jeremy Roscoe, Benjamin Kelmendi, Henk M. De Feyter, Robin A de Graaf, Ralitza Gueorguieva, Gerard Sanacora, John H. Krystal, Douglas L. Rothman, Graeme F. Mason, Chadi G. Abdallah
Publikováno v:
Chronic Stress, Vol 6 (2022)
Background Trauma and chronic stress are believed to induce and exacerbate psychopathology by disrupting glutamate synaptic strength. However, in vivo in human methods to estimate synaptic strength are limited. In this study, we established a novel p
Externí odkaz:
https://doaj.org/article/9a7f7965ac9f4df9a4deec5793fd8086
Autor:
Chadi G. Abdallah, John D. Roache, Ralitza Gueorguieva, Lynnette A. Averill, Stacey Young-McCaughan, Paulo R. Shiroma, Prerana Purohit, Antoinette Brundige, William Murff, Kyung-Heup Ahn, Mohamed A. Sherif, Eric J. Baltutis, Mohini Ranganathan, Deepak D’Souza, Brenda Martini, Steven M. Southwick, Ismene L. Petrakis, Rebecca R. Burson, Kevin B. Guthmiller, Argelio L. López-Roca, Karl A. Lautenschlager, John P. McCallin, Matthew B. Hoch, Alexandar Timchenko, Sergio E. Souza, Charles E. Bryant, Jim Mintz, Brett T. Litz, Douglas E. Williamson, Terence M. Keane, Alan L. Peterson, John H. Krystal
Publikováno v:
Neuropsychopharmacology
This study tested the efficacy of repeated intravenous ketamine doses to reduce symptoms of posttraumatic stress disorder (PTSD). Veterans and service members with PTSD (n = 158) who failed previous antidepressant treatment were randomized to 8 infus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09c4fdc832b9bd91e5f00241c594505
https://doi.org/10.1038/s41386-022-01266-9
https://doi.org/10.1038/s41386-022-01266-9
Autor:
Steven M. Southwick, Ralitza Gueorguieva, Mohamed Sherif, Chadi G. Abdallah, Kyung-Heup Ahn, Mohini Ranganathan, Lynnette A. Averill, Gerard Sanacora, Deepak Cyril D'Souza, Selin Goktas, Richard N. Formica, Ronald S. Duman, Prerana Purohit, John H. Krystal
Publikováno v:
Neuropsychopharmacology
Twenty-four hours after administration, ketamine exerts rapid and robust antidepressant effects that are thought to be mediated by activation of the mechanistic target of rapamycin complex 1 (mTORC1). To test this hypothesis, depressed patients were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105a747ec88f46c492891f019ea9a9e7
https://doi.org/10.1038/s41386-020-0644-9
https://doi.org/10.1038/s41386-020-0644-9
Autor:
Chadi G. Abdallah, John D. Roache, Ralitza Gueorguieva, Lynnette A. Averill, Stacey Young-McCaughan, Paulo R. Shiroma, Prerana Purohit, Antoinette Brundige, William Murff, Kyung-Heup Ahn, Mohamed A. Sherif, Eric J. Baltutis, Mohini Ranganathan, Deepak D’Souza, Brenda Martini, Steven M. Southwick, Ismene L. Petrakis, Rebecca R. Burson, Kevin B. Guthmiller, Argelio L. López-Roca, Karl A. Lautenschlager, John P. McCallin, Matthew B. Hoch, Alexandar Timchenko, Sergio E. Souza, Charles E. Bryant, Jim Mintz, Brett T. Litz, Douglas E. Williamson, Terence M. Keane, Alan L. Peterson, John H. Krystal
Publikováno v:
Neuropsychopharmacology. 47:1583-1584
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c77bd6aa786f18b90a4f7f24b1779c9d
https://doi.org/10.1038/s41386-022-01339-9
https://doi.org/10.1038/s41386-022-01339-9
Autor:
Chadi G. Abdallah, Lynnette A. Averill, Eric J. Baltutis, Douglas E. Williamson, Ralitza Gueorguieva, Deepak Cyril D'Souza, Mohamed Sherif, John H. Krystal, Mohini Ranganathan, Jim Mintz, Paulo R. Shiroma, Argelio L. López-Roca, Sergio E. Souza, Charles E. Bryant, Antoinette Brundige, Kevin Guthmiller, Stacey Young-McCaughan, Brenda Martini, Prerana Purohit, Matthew B. Hoch, Kyung-Heup Ahn, Alexandar Timchenko, Alan L. Peterson, John P. McCallin, Ismene L. Petrakis, Steven M. Southwick, Rebecca R. Burson, William L. Murff, John D. Roache, Brett T. Litz, Karl Alan Lautenschlager, Terence M. Keane
BackgroundThis study tested the efficacy of repeated intravenous ketamine doses to reduce antidepressant-resistant symptoms of posttraumatic stress disorder (PTSD).MethodsVeterans and service members with PTSD (n=158) who failed previous antidepressa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c168949803aa71976e13cffeaf4025fa
https://doi.org/10.1101/2021.04.30.21256273
https://doi.org/10.1101/2021.04.30.21256273
Autor:
Selin Goktas, Steven M. Southwick, Chadi G. Abdallah, John H. Krystal, Lynnette A. Averill, Gerard Sanacora, Deepak Cyril D'Souza, Richard N. Formica, Ralitza Gueorguieva, Ronald S. Duman, Prerana Purohit, Mohini Ranganathan
BACKGROUND: Ketamine exerts rapid and robust antidepressant effects thought to be mediated by activation of the mechanistic target of rapamycin complex 1 (mTORC1). To test this hypothesis, depressed patients were pretreated with rapamycin, an mTORC1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd2b6a7ef571f2cc5c7e0e53b6ba237
https://doi.org/10.1101/500959
https://doi.org/10.1101/500959
Autor:
Golam M. I. Chowdhury, Graeme F. Mason, Chadi G. Abdallah, Christoph Juchem, Douglas L. Rothman, Brian Pittman, Irina Esterlis, Lihong Jiang, Robin A. de Graaf, Gerard Sanacora, John H. Krystal, Henk M. De Feyter, Prerana Purohit, Christopher L. Averill, Lynnette A. Averill
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 43(10)
The ability of ketamine administration to activate prefrontal glutamate neurotransmission is thought to be a key mechanism contributing to its transient psychotomimetic effects and its delayed and sustained antidepressant effects. Rodent studies empl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca717cd2a311e50eb11c03656afaa6a4
https://pubmed.ncbi.nlm.nih.gov/29977074
https://pubmed.ncbi.nlm.nih.gov/29977074