PET clinical study of novel antipsychotic LB-102 demonstrates unexpectedly prolonged dopamine receptor target engagement.

Autor: Wong DF; Mallinckrodt Institute of Radiology, and Department of Radiology, Washington University in Saint Louis, St. Louis, MO, USA. dfwong@wustl.edu.; Department of Psychiatry, Washington University in Saint Louis, St. Louis, MO, USA. dfwong@wustl.edu.; Department of Neurology, Washington University in Saint Louis, St. Louis, MO, USA. dfwong@wustl.edu.; Department of Neuroscience, Washington University in Saint Louis, St. Louis, MO, USA. dfwong@wustl.edu., Chand GB; Mallinckrodt Institute of Radiology, and Department of Radiology, Washington University in Saint Louis, St. Louis, MO, USA., Caito N; Mallinckrodt Institute of Radiology, and Department of Radiology, Washington University in Saint Louis, St. Louis, MO, USA., Eramo A; LB Pharmaceuticals Inc., New York, NY, USA., Grattan VT; LB Pharmaceuticals Inc., New York, NY, USA., Hixon MS; Mark S. Hixon Consulting LLC, San Diego, CA, USA., Nicol G; Department of Psychiatry, Washington University in Saint Louis, St. Louis, MO, USA., Lessie E; Mallinckrodt Institute of Radiology, and Department of Radiology, Washington University in Saint Louis, St. Louis, MO, USA., Prensky Z; LB Pharmaceuticals Inc., New York, NY, USA., Kuwabara H; Johns Hopkins University Department of Radiology, Baltimore, MD, USA., Tian L; Mallinckrodt Institute of Radiology, and Department of Radiology, Washington University in Saint Louis, St. Louis, MO, USA., Valenta I; Mallinckrodt Institute of Radiology, and Department of Radiology, Washington University in Saint Louis, St. Louis, MO, USA., Schindler TH; Mallinckrodt Institute of Radiology, and Department of Radiology, Washington University in Saint Louis, St. Louis, MO, USA., Gründer G; Central Institute of Mental Health, Department of Molecular Neuroimaging, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Vaino AR; LB Pharmaceuticals Inc., New York, NY, USA. andrew@lbpharma.us.

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2024 Oct 16. Date of Electronic Publication: 2024 Oct 16.

P.0830 LB-102 displays superior dopamine receptor occupancy compared to amisulpride in mouse and human PET studies

Autor: Vaino, A., Mintz, A., Eramo, A., Caito, N., Chand, G., Nicol, G., Hixon, M., Grattan, V., Prensky, Z., Molotkov, A., Dolan, M., Oya, S., Cabrera, M., Wang, L., Wong, D.

Publikováno v: In European Neuropsychopharmacology December 2021 53 Supplement 1:S606-S606

P.101 Building a translational bridge from animals to man for clinical candidate lb-102, a next-generation benzamide antipsychotic

Autor: Vaino, A., Grattan, V., Prensky, Z., Hixon, M.

Publikováno v: In European Neuropsychopharmacology December 2019 29 Supplement 6:S87-S88

Current emerging therapeutic targets and clinical investigational agents for schizophrenia: Challenges and opportunities.

Autor: Ye N; Jiangsu Key Laboratory of Neuropsychiatric Diseases & College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.; Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Soochow University, Suzhou, China., Wang Q; Jiangsu Key Laboratory of Neuropsychiatric Diseases & College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China., Li Y; Jiangsu Key Laboratory of Neuropsychiatric Diseases & College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China., Zhen X; Jiangsu Key Laboratory of Neuropsychiatric Diseases & College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.; Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Soochow University, Suzhou, China.

Publikováno v: Medicinal research reviews [Med Res Rev] 2024 Sep 19. Date of Electronic Publication: 2024 Sep 19.

P.3.c.005 - Pre-clinical evaluation of two novel benzamides, LB-102 and 103, for the treatment of schizophrenia

Autor: Neill, J., Grayson, B., Podda, G., Cadinu, D., Beconi, M., Grattan, V., Hixon, M.S., Prensky, Z., Vaino, A.

Publikováno v: In European Neuropsychopharmacology October 2017 27 Supplement 4:S922-S923