Development & automation of a novel [18F]F prosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide

Autor: Morris, Olivia, Gregory, J., Kadirvel, M., Henderson, Fiona, Blykers, A., McMahon, Adam, Taylor, Mark, Allsop, David, Allan, Stuart, Grigg, J., Boutin, Herve, Prenant, Christian

Publikováno v: In Applied Radiation and Isotopes October 2016 116:120-127

Brain inflammation is induced by co-morbidities and risk factors for stroke

Autor: Drake, Caroline, Boutin, Hervé, Jones, Matthew S., Denes, Adam, McColl, Barry W., Selvarajah, Johann R., Hulme, Sharon, Georgiou, Rachel F., Hinz, Rainer, Gerhard, Alexander, Vail, Andy, Prenant, Christian, Julyan, Peter, Maroy, Renaud, Brown, Gavin, Smigova, Alison, Herholz, Karl, Kassiou, Michael, Crossman, David, Francis, Sheila, Proctor, Spencer D., Russell, James C., Hopkins, Stephen J., Tyrrell, Pippa J., Rothwell, Nancy J., Allan, Stuart M.

Publikováno v: In Brain Behavior and Immunity August 2011 25(6):1113-1122

Automation of [18F]fluoroacetaldehyde synthesis: application to a recombinant human interleukin‐1 receptor antagonist (rhIL‐1RA)

Autor: Morris, Olivia, Mcmahon, Adam, Boutin, Herve, Grigg, Julian, Prenant, Christian

Publikováno v: Journal of Labelled Compounds & Radiopharmaceuticals
Morris, O, Mcmahon, A, Boutin, H, Grigg, J & Prenant, C 2016, ' Automation of [18F]fluoroacetaldehyde synthesis: application to a recombinant human interleukin-1 receptor antagonist (rhIL-1RA) ', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 59, no. 7, pp. 277-283 . https://doi.org/10.1002/jlcr.3393

[(18) F]Fluoroacetaldehyde is a biocompatible prosthetic group that has been implemented pre-clinically using a semi-automated remotely controlled system. Automation of radiosyntheses permits use of higher levels of [(18) F]fluoride whilst minimising

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::40c7576552b8969b8bdb787b7b2b27ec
http://europepmc.org/articles/PMC4913750

In vivo characterisation of a therapeutically relevant self-assembling 18F- labelled β-sheet forming peptide and its hydrogel using positron emission tomography

Autor: Morris, Olivia, Elsawy, Mohamed, Fairclough, Michael, Williams, Kaye, Mcmahon, Adam, Grigg, J., Forster, Duncan, Miller, A.F., Saiani, Alberto, Prenant, Christian

Publikováno v: Morris, O, Elsawy, M, Fairclough, M, Williams, K, Mcmahon, A, Grigg, J, Forster, D, Miller, A F, Saiani, A & Prenant, C 2017, ' In vivo characterisation of a therapeutically relevant self-assembling 18F-labelled β-sheet forming peptide and its hydrogel using positron emission tomography ', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 60, no. 10 . https://doi.org/10.1002/jlcr.3534

The Publisher's final version can be found by following the DOI link. open access article Positron emission tomography (PET) and fluorescence labelling have been used to assess the pharmacokinetics, biodistribution and eventual fate of a hydrogel‐f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b6ea64aae8f186e1e204279fa58f943f
https://dora.dmu.ac.uk/handle/2086/19083

The automated radiosynthesis and purification of the opioid receptor antagonist, [6-O-methyl-11C]diprenorphine on the GE TRACERlab FXFE radiochemistry module

Autor: Fairclough, Michael, Prenant, Christian, Brown, Gavin, Mcmahon, Adam, Lowe, Jonathan, Jones, AKP

Publikováno v: Fairclough, M, Prenant, C, Brown, G, Mcmahon, A, Lowe, J & Jones, AKP 2014, ' The automated radiosynthesis and purification of the opioid receptor antagonist, [6-O-methyl-11C]diprenorphine on the GE TRACERlab FXFE radiochemistry module. ', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 57, no. 5, pp. 388-396 . https://doi.org/10.1002/jlcr.3194

[6-O-Methyl-(11)C]diprenorphine ([(11)C]diprenorphine) is a positron emission tomography ligand used to probe the endogenous opioid system in vivo. Diprenorphine acts as an antagonist at all of the opioid receptor subtypes, that is, μ (mu), κ (kapp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::3f76b19639cb3d055ab2f90b6e017377
https://doi.org/10.1002/jlcr.3194