Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Premilla Arasasingham"'
Autor:
Nuria A. Tamayo, Shimin Xu, Michael G. Kelly, Duncan M. Smith, Ning Chen, Michelle Carmouche, Mark H. Norman, Martin H. Goldberg, James Davis, Christopher H. Fotsch, Clarence Hale, Ning Xi, Markian Stec, James W. Baumgartner, Premilla Arasasingham, Nianhe Han, Feng-Yin Hsieh, Qingyian Liu, Yunxin Bo, Anthony W. Bannon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1623-1627
The biological activity for a set of melanocortin-4 receptor (MC4R) agonists containing a piperazine core with an ortho-substituted aryl sulfonamide is described. Compounds from this set had binding and functional activities at MC4R less than 30 nM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e26bb6cb3766754fe8c0250af2dfad
https://doi.org/10.1016/j.bmcl.2005.01.060
https://doi.org/10.1016/j.bmcl.2005.01.060
Autor:
Xiaohu Ouyang, Christopher H. Fotsch, Kevin Lee Stark, Mark H. Norman, Bill Karbon, Nuria A. Tamayo, Janet Cheetham, James W. Baumgartner, Martha Zambrano, Michael G. Kelly, Premilla Arasasingham, Clarence Hale
Publikováno v:
Journal of Medicinal Chemistry. 46:9-11
Agouti-related protein (AGRP) is an endogenous antagonist of the melanocortin action.(1) In the hypothalamus, melanocortin peptide agonists act as satiety-inducing factors that mediate their action through the melanocortin-4 receptor (MC4R) whereas A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297a05d8180b0d7331be2fa82a9dd52e
https://doi.org/10.1021/jm0255522
https://doi.org/10.1021/jm0255522