Potent Synergy between Spirocyclic Pyrrolidinoindolinones and Fluconazole against Candida albicans

Autor: Premachandra, Ilandari Dewage Udara Anulal, Scott, Kevin A, Shen, Chengtian, Wang, Fuqiang, Lane, Shelley, Liu, Haoping, Van Vranken, David L

Publikováno v: ChemMedChem, vol 10, iss 10

A spiroindolinone, (1S,3R,3aR,6aS)-1-benzyl-6'-chloro-5-(4-fluorophenyl)-7'-methylspiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3'-1H-indole]-2',4,6-trione, was previously reported to enhance the antifungal effect of fluconazole against Candida a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::f8b706c50de4835a99fea7846c3345c8
https://escholarship.org/uc/item/49c5k64p

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Enantioselective Palladium-Catalyzed Carbene Insertion into the N−H Bonds of Aromatic Heterocycles.

Autor: Arredondo, Vanessa, Hiew, Stanley C., Gutman, Eugene S., Premachandra, Ilandari Dewage Udara Anulal, Van Vranken, David L.

Publikováno v: Angewandte Chemie; 4/3/2017, Vol. 129 Issue 15, p4220-4223, 4p

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Potent Synergy between Spirocyclic Pyrrolidinoindolinones and Fluconazole against Candida albicans.

Autor: Premachandra ID; Department of Chemistry, University of California, Irvine, 1102 Natural Sciences 2, Irvine, CA 92697-2025 (USA)., Scott KA; Department of Chemistry, University of California, Irvine, 1102 Natural Sciences 2, Irvine, CA 92697-2025 (USA)., Shen C; Department of Chemistry, University of California, Irvine, 1102 Natural Sciences 2, Irvine, CA 92697-2025 (USA)., Wang F; Department of Biological Chemistry, University of California, Irvine, 825 Health Sciences Road, Medical Sciences I, Irvine, CA 92697-1700 (USA)., Lane S; Department of Biological Chemistry, University of California, Irvine, 825 Health Sciences Road, Medical Sciences I, Irvine, CA 92697-1700 (USA)., Liu H; Department of Biological Chemistry, University of California, Irvine, 825 Health Sciences Road, Medical Sciences I, Irvine, CA 92697-1700 (USA)., Van Vranken DL; Department of Chemistry, University of California, Irvine, 1102 Natural Sciences 2, Irvine, CA 92697-2025 (USA). david.vv@uci.edu.

Publikováno v: ChemMedChem [ChemMedChem] 2015 Oct; Vol. 10 (10), pp. 1672-86. Date of Electronic Publication: 2015 Aug 12.