Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Prem M. Sharma"'
Autor:
Pamela L. Mellon, Devendra S. Mistry, R. Jeffery Chang, Shweta Sharma, Jerrold M. Olefsky, Nicholas J. G. Webster, Prem M. Sharma
Publikováno v:
Biology of Reproduction. 84:466-475
Peroxisome proliferators-activated receptor gamma (PPARG) ligands improve insulin sensitivity in type 2 diabetes and polycystic ovarian syndrome (PCOS). Despite clinical studies showing normalization of pituitary responsiveness to gonadotropin-releas
Autor:
Prem M. Sharma, Andrej Janez, Anja Silic, Mojca Matičič, Primoz Karner, J Tomazic, Ludvik Vidmar
Publikováno v:
Croatian medical journal. 48:791-799
To evaluate and compare effects of 48-week treatment with rosiglitazone and metformin on insulin resistance in patients infected with Human Immunodeficiency Virus (HIV) receiving highly active antiretroviral therapy (HAART), containing a protease inh
Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras
Autor:
Bonghee Lee, Il-Yup Chung, Julian Downward, Young Seek Lee, Hermann Eibel, Prem M. Sharma, Soon Young Shin, Young Yil Bahk, Jerrold M. Olefsky, Young Ho Kim, Young Han Lee, Jesang Ko
Publikováno v:
The EMBO Journal. 25:1093-1103
The transcription factor Egr-1 functions as a key regulator in cellular growth, differentiation, and apoptosis. The loss of Egr-1 expression is closely associated with tumor development, although the molecular mechanism behind the suppression of Egr-
Publikováno v:
Molecular and Cellular Endocrinology. 205:99-106
Insulin-like growth factor-1 (IGF 1) suppresses myocardial apoptosis and improves myocardial function in experimental models of cardiomyopathy. Apoptosis is triggered by mitochondria dysfunction and subsequent activation of caspases. We had previousl
Publikováno v:
Diabetologia. 45:502-508
Aims/hypothesis. The cellular mechanisms for the insulin resistance in pregnancy and gestational diabetes mellitus are not known. The membrane protein plasma cell glycoprotein PC-1 has been identified as an inhibitor of insulin receptor tyrosine kina
Autor:
Prem M. Sharma, Satoshi Ugi, Ken-ichi Ishibashi, Jerrold M. Olefsky, Jie Huang, Takeshi Imamura
Publikováno v:
Journal of Clinical Investigation. 107:1193-1202
We recently reported that insulin and endothelin-1 (ET-1) can stimulate GLUT4 translocation via the heterotrimeric G protein G alpha q/11 and through PI3-kinase--mediated pathways in 3T3-L1 adipocytes. Because both hormones stimulate glucose transpor
Autor:
J. Wayne Leitner, Boris Draznin, Marc L. Goalstone, Paulos Berhanu, Prem M. Sharma, Jerrold M. Olefsky
Publikováno v:
Journal of Biological Chemistry. 276:12805-12812
We assessed the roles of insulin receptor substrate-1 (IRS-1) and Shc in insulin action on farnesyltransferase (FTase) and geranylgeranyltransferase I (GGTase I) using Chinese hamster ovary (CHO) cells that overexpress wild-type human insulin recepto
Autor:
Ping H. Wang, Andy Jang, Weihua Wu, Tsun Jui Liu, Daniel Chen, Wen Lieng Lee, Yvonne Y. Wu, Prem M. Sharma
Publikováno v:
Journal of Biological Chemistry. 275:40113-40119
Apoptosis of cardiac muscle cells contributes to the development of cardiomyopathy. Recent studies showed that insulin-like growth factor I (IGF-I) inhibits apoptosis of cardiac muscle cells and improves myocardial function in experimental heart fail
Autor:
Junko Kawahara, Tatsuhito Uno, Prem M. Sharma, Tetsuro Haruta, Katsuya Egawa, Atsuko Takano, Masashi Kobayashi, Jerrold M. Olefsky
Publikováno v:
Molecular Endocrinology. 14:783-794
Insulin receptor substrate-1 (IRS-1) is a major substrate of the insulin receptor and acts as a docking protein for Src homology 2 domain containing signaling molecules that mediate many of the pleiotropic actions of insulin. Insulin stimulation elic
Autor:
Jerrold M. Olefsky, Atsunori Kashiwagi, Yoshio Nagai, Katsuya Egawa, Prem M. Sharma, Ryuichi Kikkawa, Naoki Nakashima, Hiroshi Maegawa
Publikováno v:
Endocrinology. 141:1930-1935
Recently, we have reported that the overexpression of a membrane-targeted phosphatidylinositol (PI) 3-kinase (p110CAAX) stimulated p70S6 kinase, Akt, glucose transport, and Ras activation in the absence of insulin but inhibited insulin-stimulated gly