Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Prem M. S. Chauhan"'
Autor:
Deepti Singh, Gaurav Sharma, Pooja Purohit, Pradeep Singh Chouhan, Sanjeev K. Shukla, Prem M. S. Chauhan, Ruchir Kant
Publikováno v:
ChemistrySelect. 6:1216-1222
Publikováno v:
ChemistrySelect. 5:6780-6785
Autor:
Pradeep Singh Chouhan, Anand Kumar Pandey, Mahendra Shukla, Prem M. S. Chauhan, Pooja Purohit, Deepti Singh, Jawahar Lal, Neena Goyal, Karthik Ramalingam
Publikováno v:
MedChemComm. 8:1824-1834
A series of 2,3,4,9-tetrahydro-β-carboline tetrazole derivatives (14a–u) have been synthesized utilizing the Ugi multicomponent reaction and were identified as potential antileishmanial chemotypes. Most of the screened derivatives exhibited signif
Autor:
Suman Gupta, Shashi Pandey, Swati Jaiswal, Rahul Shivahare, Abhisheak Sharma, Jawahar Lal, Shikha S. Chauhan, Prem M. S. Chauhan
Publikováno v:
European Journal of Medicinal Chemistry. 110:237-245
A novel series of highly diverse indole-2-carboxamides was synthesized utilizing the isocyanide based multicomponent reaction (IMCR)-post modification approach and were identified as potential antileishmanial chemotype. Among the synthesized 18 analo
Publikováno v:
RSC Advances. 6:21165-21186
A one-pot domino multicomponent reaction for the rapid, integrated and versatile synthesis of highly functionalized β-carbolinones (9a–9ab) and indolo-pyrazinones (10a–10ab) has been established. The reaction involves an Ugi-four component react
Autor:
Anirudha, Karvande, Shahnawaz, Khan, Irfan, Khan, Deepti, Singh, Vikram, Khedgikar, Priyanka, Kushwaha, Naseer, Ahmad, Priyanka, Kothari, Anupam, Dhasmana, Ruchir, Kant, Ritu, Trivedi, Prem M S, Chauhan
Publikováno v:
MedChemComm. 9(7)
β-Carbolines have been assessed for osteoclastogenesis. However, their effect on osteoblasts during estrogen deficiency is still unclear. Here, a series of novel piperazine and tetrazole tag β-carbolines have been synthesized and examined for osteo
Autor:
Ruchir Kant, Sanjeev K. Shukla, Irfan Khan, Moni Sharma, Rohit Mahar, Shahnawaz Khan, Prem M. S. Chauhan
Publikováno v:
Tetrahedron Letters. 56:5401-5408
A novel and robust route for the synthesis of diversely substituted isoindoline skeletons through a ligand-free Pd-catalyzed cascade consisting of isocyanide insertion into Ugi-tetrazole has been developed. The tetrazole precursor is prepared in one
Autor:
Karthik Ramalingam, Preeti Vishwakarma, Prem M. S. Chauhan, Shashi Pandey, Mohd Imran Siddiqi, Shikha S. Chauhan, Rahul Shivahare, Sanjay Krishna, Neena Goyal, Suman Gupta
Publikováno v:
MedChemComm. 6:351-356
Trypanothione reductase (TR) is a vital enzyme in the trypanothione based redox metabolism of trypanosomatid parasites. It is one of the few chemically validated targets for Leishmania. Herein, we report the synthesis of novel β-carboline–quinazol
Publikováno v:
RSC Advances. 5:102713-102722
An expedient construction of tetrahydro-β-carbolinediketopiperazine ring systems, which are present in various indole alkaloids, is documented. The synthetic strategy proceeds through a Pictet–Spengler reaction followed by an Ugi-4CR and deprotect
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4166-4170
In search of potential therapeutics for tuberculosis, we describe here the synthesis and in vitro antitubercular activity of a novel series of thiazolone piperazine tetrazole derivatives. Among all the synthesized derivatives, four compounds (10, 14,