Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Prem L. Sharma"'
Publikováno v:
Viral Immunology. 25:12-20
Clinical trials with highly-active antiretroviral therapy (HAART) have shown that a substantial number of patients continue to show a decrease in viral load and/or increase or stable CD4(+) T-cell numbers even in the presence of multidrug resistant (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39760a69afe0fbd137b1acf054352c7
https://doi.org/10.1089/vim.2011.0057
https://doi.org/10.1089/vim.2011.0057
Publikováno v:
Virology. 414(1):34-41
In addition to K65R, the other mutation observed at HIV-1 RT codon 65 is K65N. While K65N appears to have a phenotypic effect similar to K65R, it is less frequent during clinical trials. We compared the relative impact of K→N with respect to K→R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3aafc1c785037ab9f66c103ee5d502
Autor:
Leda Bassit, Christine A. Larsen, James R. Prudent, Amanda J. Swearingen, Prem L. Sharma, Meta Ruckstuhl, Michael J. Moser, Miroslaw Kozlowski, Raymond F. Schinazi
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:3334-3340
In order to survive prolonged treatment with antiretroviral nucleoside analogs, the human immunodeficiency virus type 1 (HIV-1) is selectively forced to acquire mutations in the reverse transcriptase (RT) gene. Some of these mutations are more common
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0154dc96574710f05d5c70e3e1ba7bef
https://doi.org/10.1128/aac.49.8.3334-3340.2005
https://doi.org/10.1128/aac.49.8.3334-3340.2005
Autor:
Brenda I. Hernandez-Santiago, Raymond F. Schinazi, Thierry Beltran, Prem L. Sharma, Viktoria Nurpeisov
Publikováno v:
Current Topics in Medicinal Chemistry. 4:895-919
The development of novel compounds that can effectively inhibit both wild type and the most consensus resistant strains of human immunodeficiency virus type 1 (HIV-1) is the primary focus in HIV disease management. Combination therapy, comprising at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f9da588bbe847ae8140ba96c15ffe5
https://doi.org/10.2174/1568026043388484
https://doi.org/10.2174/1568026043388484
Autor:
Christina Amat di San Filippo, Sara Skaggs, Raymond F. Schinazi, Viktoria Nurpeisov, Prem L. Sharma, Kimberly Lee
Publikováno v:
Virology. 321(2):222-234
Understanding of the mechanisms of interaction among nucleoside reverse transcriptase inhibitor (NRTI)-selected mutations in the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) coding sequence is essential for the design of new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75db5f131c16f7570ce4b440b339bc3
Autor:
Robert A. Rasmussen, An Li, Timothy W. Baba, Ruth M. Ruprecht, Seyoum Ayehunie, Prem L. Sharma, Yuwen Hu, Vladimir Liska
Publikováno v:
Seminars in Virology. 7:147-155
Anti-HIV-1 vaccines must be safe and effective. In macaques, live attenuated simian immunodeficiency viruses have provided the best protection to date. Similar results were obtained earlier in murine leukemia virus systems in which protection correla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08c1334db6a92ddaa0120fc04223f832
https://doi.org/10.1006/smvy.1996.0019
https://doi.org/10.1006/smvy.1996.0019
Publikováno v:
AIDS. 10:S33-40
By considering the dynamic relationship between retroviruses and their hosts, we have developed a unifying hypothesis to explain such disparate clinical phenomena as differential pathogenicity of a given virus in adults and neonates, transient infect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c6423c54e90524857bd68ca23d7106
https://doi.org/10.1097/00002030-199601001-00005
https://doi.org/10.1097/00002030-199601001-00005
Publikováno v:
Virology Journal, Vol 8, Iss 1, p 33 (2011)
Virology Journal
Virology Journal
Background The major hurdle in the treatment of Human Immunodeficiency virus type 1 (HIV-1) includes the development of drug resistance-associated mutations in the target regions of the virus. Since reverse transcriptase (RT) is essential for HIV-1 r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523e39630019c29161a18b5f4fb44712
http://www.virologyj.com/content/8/1/33
http://www.virologyj.com/content/8/1/33
Publikováno v:
Proceedings of the National Academy of Sciences. 90:630-634
Mutations having pleiotropic effects on polar organelle development (pod) in Caulobacter crescentus have been identified and shown to occur in at least 13 genes scattered throughout the genome. Mutations at each locus affect a unique combination of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd3de1370c2551047f8fb9728a4cc6f
https://doi.org/10.1073/pnas.90.2.630
https://doi.org/10.1073/pnas.90.2.630
Publikováno v:
AIDS Research and Human Retroviruses. 8:997-1011
Murine models with type C murine leukemia viruses have been used to develop major new prophylactic and therapeutic strategies in vaccination, drug therapy of acute virus exposure and chronic viremia, combination therapy, prevention of maternal transm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8b134a9c931ab1823b72f819d58273
https://doi.org/10.1089/aid.1992.8.997
https://doi.org/10.1089/aid.1992.8.997